The role of vitamin D in skeletal and cardiac muscle function

Polly, Patsie; Tan, Timothy C.

doi:10.3389/fphys.2014.00145

Cited by 57 publications

(44 citation statements)

References 83 publications

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“…Data analysis was performed on natural logarithmic transformed values. 15 Data were adjusted for age, gender, race-ethnicity, BMI, physical activity, and smoking status, as well as for interactions between age and BMI; gender and BMI; gender and smoking status; and BMI and physical activity. Data analysis was performed on natural logarithmic transformed values.…”

Section: Serum 25(oh)d Concentrations Mets and Diabetesmentioning

confidence: 99%

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitness in US Adults

2020

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A serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration of ≥75 nmol/L is recommended for optimal health. We investigated the relationship between serum 25(OH)D and metabolic syndrome (MetS), diabetes, cardiometabolic biomarkers, and cardiorespiratory fitness (CRF) in US adults using clinical cut points recommended by health organizations. Data from USA’s National Health and Nutrition Examination Surveys were used. Prevalences and likelihood of having MetS and diabetes according to clinical cut points for serum 25(OH)D (<30 nmol/L, 30-<50 nmol/L, 50-<75 nmo/L, and ≥75 nmol/L) were determined with multivariate logistic regression. Relations between serum 25(OH)D and various cardiometabolic biomarkers, CRF, MetS, and diabetes were tested using multivariable adjusted regression. Prevalence of MetS and diabetes were significantly lower in individuals with serum 25(OH)D ≥75 nmol/L (MetS, 21.6%; diabetes, 4.1%) compared to those with 25(OH)D <30 nmol/L (MetS, 45.5%; diabetes, 11.6%) (p < 0.0001). Individuals with serum 25(OH)D ≥75 nmol/L had significantly lower waist circumference (p < 0.0001), C-reactive protein (p = 0.003), glycated hemoglobin (p < 0.0002), fasting triglycerides (p < 0.0001), total homocysteine (p < 0.0001), and insulin resistance (p = 0.0001) and had significantly higher HDL-cholesterol (p < 0.0001) and maximal oxygen uptake (marker for CRF) (p< 0.0009) compared to those with 25(OH)D <30 nmol/L. In conclusion, serum 25(OH)D ≥75 nmol/L is associated with positive indicators related to cardiometabolic diseases in US adults.

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Section: Serum 25(oh)d Concentrations Mets and Diabetesmentioning

confidence: 99%

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitness in US Adults

2020

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“…VDRs, found on both the cell and nuclear membranes [3,4], have an influence through genomic and non-genomic pathways in the function and structure of cardiomyocytes and cardiovascular system cells [115,116]. It has also been reported that within this broad group of receptors, certain polymorphisms can be used as predictors for developing left ventricular hypertrophy in patients with end stage kidney disease [117] or other diseases, such as Gaucher’s variant heart disease [118].…”

Section: Vitamin D and Molecular Biologymentioning

confidence: 99%

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Pérez-Hernández

Aptilon-Duque

Nostroza-Hernández

et al. 2016

Korean J Intern Med

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Vitamin D is a molecule that is actively involved in multiple metabolic pathways. It is mostly known for its implications related to calcium metabolism. It has also been determined that it actively participates in the cardiovascular system, influencing blood pressure, coronary artery disease and other vascular diseases, such as heart failure and atrial fibrillation. Furthermore, it has been established that this vitamin is extensively involved in the regulation of both the renin angiotensin aldosterone system and the immune system. In this review, we present the different vitamin D metabolic pathways associated with the cardiovascular pathophysiology, and we include studies in animal and human models, as well as some of the controversies found in the literature. This review also incorporates an overview of the implications in the molecular biology and public health fields.

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“…The positive effects of vitamin D supplementation on muscle strength, physical performance and quality of life have been attributed to the influence of vitamin D on myocyte and neuron metabolism and function [13][14][15][16] . To the best of our knowledge, relatively few studies have focused on the effects of vitamin D and calcium supplementation on the physical performance and quality of life in Asian populations, especially in the Chinese population.…”

Section: Huang Et Al Demonstrated That Vitamin D Supplementationmentioning

confidence: 99%

Physical performance and life quality in postmenopausal women supplemented with vitamin D: a two-year prospective study

et al. 2015

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Aim: To investigate the effects of calcium and vitamin D supplementation on bone turnover marker levels, muscle strength and quality of life in postmenopausal Chinese women. Methods: A total of 485 healthy postmenopausal Chinese women (63.44±5.04 years) were enrolled in this open-label, 2-year, prospective, community-based trial. The participants were divided into group A, B, C, which were treated with calcium (600 mg/d) alone, calcium (600 mg/d) and cholecalciferol (800 IU/d) or calcium (600 mg/d) and calcitriol (0.25 μg/d), respectively, for 2 years. Serum levels of 25-hydroxyvitamin D, parathyroid hormone, β-CTX and P1NP were measured, and the muscle strength and quality of life were assessed at baseline and at 12-and 24-month follow-ups. Results: Four hundred and sixty one participants completed this study. Serum levels of 25-hydroxyvitamin D were significantly increased in group C, but not changed in groups A and B at 24-month follow-up. Serum levels of parathyroid hormone, bone turnover marker β-CTX and bone formation marker P1NP were significantly decreased in group C, while serum levels of β-CTX were increased in group A at 24-month follow-up. The participants in group C maintained the grip strength, while those in groups A and B exhibited decreased grip strength at 24-month follow-up. The quality of life for the participants in groups B and C remained consistent, but that in group A was deteriorated at 24-month follow-up. Conclusion: Supplementation with calcitriol and calcium modifies the bone turnover marker levels, and maintains muscle strength and quality of life in postmenopausal Chinese women, whereas supplementation with cholecalciferol and calcium prevents aging-mediated deterioration in quality of life.

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The role of vitamin D in skeletal and cardiac muscle function

Cited by 57 publications

References 83 publications

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitness in US Adults

Serum Vitamin D Concentration ≥75 nmol/L Is Related to Decreased Cardiometabolic and Inflammatory Biomarkers, Metabolic Syndrome, and Diabetes; and Increased Cardiorespiratory Fitness in US Adults

Vitamin D and its effects on cardiovascular diseases: a comprehensive review

Physical performance and life quality in postmenopausal women supplemented with vitamin D: a two-year prospective study

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