The role of vitamin D receptor gene polymorphisms in the bone mineral density of Greek postmenopausal women with low calcium intake

Stathopoulou, Maria G.; Dedoussis, George; Trovas, George; Theodoraki, Eirini; Katsalira, Aikaterini; Dontas, Ismene; Hammond, Naomi; Deloukas, Panos; Lyritis, George P.

doi:10.1016/j.jnutbio.2010.06.007

Cited by 24 publications

(20 citation statements)

References 50 publications

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“…The distributions of these polymorphisms were in accordance with the Hardy-Weinberg equilibrium among the controls (p = 0.679, p = 0.294, p = 0.204, p = 0.689 and p = 0.230, respectively). The frequencies of selected polymorphisms were similar to those found in previous studies made in the Turkish population [14,22,23,24] as well as to those in other studies in Caucasian populations [13,25,26]. …”

Section: Resultssupporting

confidence: 89%

Analysis of Vitamin D Receptor Gene Polymorphisms in Vitiligo

Aydıngöz

Bingül²,

Doğru‐Abbasoğlu³

et al. 2012

Dermatology

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Background: Vitiligo is a progressive depigmenting disorder characterized by the loss of functional melanocytes from the epidermis. The etiopathogenesis of vitiligo is still unclear. Vitamin D has both stimulatory and protective effects on melanocytes and acts through its nuclear vitamin D receptor (VDR) on target cells. Aim: The aim of this study was to investigate the association between VDR gene polymorphisms and susceptibility to vitiligo. Methods: 98 patients with vitiligo and 216 age- and sex-matched controls recruited from dermatology outpatients attending the same department were included in the study. Genomic DNA was extracted from peripheral blood leukocytes using a DNA isolation kit. The VDR polymorphisms of BsmI, ApaI, TaqI, FokI and Cdx2 were investigated by rapid capillary PCR with melting curve analysis. Differences in genotype distributions and allele frequencies in vitiligo cases versus controls were compared for statistical significance using χ² test. Results: Subjects with TaqI polymorphism had a 2.23-fold increased risk of developing vitiligo. Furthermore, a haplotype analysis showed that BsmI/ApaI/TaqI/FokI/Cdx2 GCCCG wassignificantly overrepresented in the vitiligo patients in comparison with controls (p = 0.031). Conclusion: This study showed that VDR TaqI gene polymorphism and the haplotype BsmI/ApaI/ TaqI/FokI/Cdx2 GCCCG may be considered as novel risk factors in vitiligo.

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Section: Resultssupporting

confidence: 89%

Analysis of Vitamin D Receptor Gene Polymorphisms in Vitiligo

Aydıngöz

Bingül²,

Doğru‐Abbasoğlu³

et al. 2012

Dermatology

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“…Several authors suggested that calcium homeostasis may play a role in this process. Stathopoulou et al [23], showed that, under lower calcium intake (<680 mg/d), the presence of the B allele of Bsm I polymorphism and of the t allele of Taq I polymorphism increased the risk of osteoporosis by 118 and 132 %, respectively. In the group of the higher (>680 mg/d) calcium intake, the influence of the VDR alleles on BMD was insignificant.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D receptor gene polymorphisms, bone mineral density and fractures in postmenopausal women with osteoporosis

et al. 2012

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The goal of the study was to investigate the possibility of an association between polymorphisms and single alleles of BsmI, ApaI, TaqI of the vitamin D receptor (VDR) gene with bone mineral density (BMD) and prevalence of vertebral/non-vertebral fractures in a group of postmenopausal Polish women with osteoporosis. The study group comprised of 501 postmenopausal females with osteoporosis (mean age 66.4 ± 8.9), who were diagnosed on the basis of either the WHO criteria or self-reported history of low-energy fractures. The three polymorphisms were determined by PCR (polymerase chain reaction) and RFLP (restriction fragment length polymorphism). BMD at the lumbar spine and femoral neck was assessed by dual energy X-ray absorptiometry (DXA). 285 fractures were reported in the whole group (168 vertebral and 117 non-vertebral). Incidence of non-vertebral fractures was significantly higher in the carriers of single alleles a of ApaI, b of BsmI and T of TaqI VDR gene polymorphisms (p = 0.021, 0.032, 0.020, respectively). No significant associations between allelic variants of the studied polymorphisms and BMD or fracture incidence were found. (1).The presence of single alleles a,b and T of ApaI, BsmI, TaqI VDR gene polymorphisms respectively, might serve as an indicator of non-vertebral fractures. (2). Lack of association between the VDR gene polymorphisms and BMD suggests that VDR contributes to low-energy fractures also through other ways.

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“…Also, it has been reported that in addition to sunlight, vitamin D status can also be influenced by several polymorphisms in vitamin D pathway genes [19], thereby modulating its biological functions in the organism. Interestingly, SNPs in the vitamin D receptor ( VDR ) gene, which affect vitamin D availability [20,21], have been associated with osteoporosis predisposition in postmenopausal women with low calcium intakes [22]. Moreover, SNPs in genes encoding lipid proteins such as apolipoprotein C3 ( APOC3 ) and apolipoprotein A1 ( APOA1 ) conferred a higher risk of metabolic syndrome in subjects with a Western dietary pattern [23,24].…”

Section: Genetic Background and Nutritional Prescriptionsmentioning

confidence: 99%

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

Ramos-López

Milagro

Allayee³

et al. 2017

Lifestyle Genomics

139

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Chronic diseases, including obesity, are major causes of morbidity and mortality in most countries. The adverse impacts of obesity and associated comorbidities on health remain a major concern due to the lack of effective interventions for prevention and management. Precision nutrition is an emerging therapeutic approach that takes into account an individual's genetic and epigenetic information, as well as age, gender, or particular physiopathological status. Advances in genomic sciences are contributing to a better understanding of the role of genetic variants and epigenetic signatures as well as gene expression patterns in the development of diverse chronic conditions, and how they may modify therapeutic responses. This knowledge has led to the search for genetic and epigenetic biomarkers to predict the risk of developing chronic diseases and personalizing their prevention and treatment. Additionally, original nutritional interventions based on nutrients and bioactive dietary compounds that can modify epigenetic marks and gene expression have been implemented. Although caution must be exercised, these scientific insights are paving the way for the design of innovative strategies for the control of chronic diseases accompanying obesity. This document provides a number of examples of the huge potential of understanding nutrigenetic, nutrigenomic, and nutriepigenetic roles in precision nutrition.

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The role of vitamin D receptor gene polymorphisms in the bone mineral density of Greek postmenopausal women with low calcium intake

Cited by 24 publications

References 50 publications

Analysis of Vitamin D Receptor Gene Polymorphisms in Vitiligo

Analysis of Vitamin D Receptor Gene Polymorphisms in Vitiligo

Vitamin D receptor gene polymorphisms, bone mineral density and fractures in postmenopausal women with osteoporosis

Guide for Current Nutrigenetic, Nutrigenomic, and Nutriepigenetic Approaches for Precision Nutrition Involving the Prevention and Management of Chronic Diseases Associated with Obesity

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