The Role of Vitamin E in Preventing and Treating Osteoarthritis – A Review of the Current Evidence

Chin, Kok‐Yong; Ima‐Nirwana, Soelaiman

doi:10.3389/fphar.2018.00946

Cited by 62 publications

(53 citation statements)

References 65 publications

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“…OA is a progressive and deteriorative disorder of articular joint, and current medicines including acetaminophen, nonsteroidal anti-inflammatory drugs, and duloxetine were only able to relieve the pain and unable to cure the disease. Inflammation and apoptosis are associated with the progress of OA, and anti-inflammatory agents could prevent OA development [18][19][20][21]. ICA, the extract of Epimedium, is known to have anti-oxidative, anti-neuroinflammatory, and anti-apoptotic effects and considered to be effective for a range of disorders, such as neoplasm, Alzheimer's disease, cerebral ischemia, depression, diabetes, and Parkinson's disease (PD) [22][23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

Zu¹,

Mu²,

Li³

et al. 2019

J Orthop Surg Res

150

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Background Osteoarthritis (OA) is the common chronic degenerative joint bone disease that is mainly featured by joint stiffness and cartilage degradation. Icariin (ICA), an extract from Epimedium, has been preliminarily proven to show anti-osteoporotic and anti-inflammatory effects in OA. However, the underlying mechanisms of ICA on chondrocytes need to be elucidated. Methods LPS-treated chondrocytes and monosodium iodoacetate (MIA)-treated Wistar rats were used as models of OA in vitro and in vivo, respectively. LDH and MTT assays were performed to detect cytotoxicity and cell viability. The expression levels of NLRP3, IL-1β, IL-18, MMP-1, MMP-13, and collagen II were detected by qRT-PCR and Western blotting. The release levels of IL-1β and IL-18 were detected by ELISA assay. Caspase-1 activity was assessed by flow cytometry. Immunofluorescence and immunohistochemistry were used to examine the level of NLRP3 in chondrocytes and rat cartilage, respectively. The progression of OA was monitored with hematoxylin-eosin (H&E) staining and safranin O/fast green staining. Results ICA could suppress LPS-induced inflammation and reduction of collagen formation in chondrocytes. Furthermore, ICA could inhibit NLRP3 inflammasome-mediated caspase-1 signaling pathway to alleviate pyroptosis induced by LPS. Overexpression of NLRP3 reversed the above changes caused by ICA. It was further confirmed in the rat OA model that ICA alleviated OA by inhibiting NLRP3-mediated pyroptosis. Conclusion ICA inhibited OA via repressing NLRP3/caspase-1 signaling-mediated pyroptosis in models of OA in vitro and in vivo, suggesting that ICA might be a promising compound in the treatment of OA.

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Section: Discussionmentioning

confidence: 99%

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

Zu¹,

Mu²,

Li³

et al. 2019

J Orthop Surg Res

150

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“…The properties of vitamin E have been known for many decades. Many studies have analyzing the effects of vitamin E in cardiovascular diseases [21], immunity [22], treating and preventing osteoarthritis [23]. However, interest in tocotrienols has awakened due to their biological effects and the therapeutic properties [24,25].…”

Section: Tocopherols and Tocotrienolsmentioning

confidence: 99%

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

et al. 2020

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Avocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g., morphea, sclerodactyly, scleroderma in bands). Besides, it was reported that it can improve the mood and quality of life of postmenopausal women in reducing menopause-related symptoms. This article aims to summarize the studies on biological effects of the avocado–soybean unsaponifiable, its chemical composition, pharmacotherapy as well as applications in autoimmune, osteoarticular and menopausal disorders. Finally, we will also discuss on its safety, toxicological and regulatory practices.

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“…T3 and TF exists naturally as alpha-(α-), beta-(β-), gamma-(γ-), and delta-(δ-) isomers depending on the position of the side chains on the chromanol ring. Both TF and T3 have been regarded as nutraceuticals with a wide range of biological activities against pathological complications, including dyslipidemia [6], cardiovascular [7], musculoskeletal, rheumatoid diseases [8][9][10][11][12][13], gastric [13], neurodegenerative [14], and metabolic diseases [6,15], as well as cancers [16]. The biological effects of T3 can be contributed by its potent anti-inflammatory, anti-oxidative, anti-tumor, cholesterol-lowering [through inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) activity] activities [8,9,17].…”

Section: Introductionmentioning

confidence: 99%

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

et al. 2020

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Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties. This review aimed to summarize the health benefits of T3, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders, as well as cancers. Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones. The efficacy of T3 in preventing/treating these NCDs is similar or greater compared to tocopherol (TF). TF may lower the efficacy of T3 because the efficacy of the combination of TF and T3 was lower than T3 alone in some studies. Data investigating the effects of T3 on osteoporosis, arthritis, and peptic ulcers in human are limited. The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials.Nutrients 2020, 12, 259 2 of 84 Nutrients 2020, 12, 259 4 of 84 the order δ > γ > β > α [45]. Using HepG2 cells, γT3 was shown to stimulate apolipoprotein B (Apo-B) degradation by decreasing its translocation into the endoplasmic reticulum (ER) lumen. This action eventually caused a reduction in the number of Apo-B in lipoprotein particles [46]. Other reports showed that γT3 and δT3 had the potential to reduce the hepatic TG synthesis and very-low-density lipoprotein (VLDL) secretion by suppressing expression of genes involved in lipid homeostasis, particularly the TG, cholesterol, and VLDL biosynthesis. Moreover, δT3 also promoted the efflux of LDL through LDL receptor expression [47]. A summary of the literature on effect of T3 supplementation on lipid profile of hypercholesterolemic model in vitro is shown in Table 1.Animal models of dyslipidemia have been used to investigate the effects of T3 on lipid profile. Several animals have been tested, including chicken, swine and rodents (rats, hamsters, guinea pigs). In chickens fed with a varying level of αTF and γT3, Qureshi et al. (1996) showed that αTF enhanced the inhibition of HMGCR by γT3. They further stipulated that the vitamin E mixture should contain 15-20% of αTF and approximately 60% of γT3 or δT3 for optimal anti-cholesterol effects [48]. In the subsequent study, demonstrated that combination of 50 ppm T3-rich fraction (TRF) and 50 ppm lovastatin was more effective in suppressing HMGCR activity compared to lovastatin alone in chickens. The combination also reduced serum TC and LDL-C, TG, Apo-B, thromboxane B 2 , and platelet factor 4 in contrast to individual treatment [49]. Using chicken supplemented with 50 ppm of δT3, Qureshi et al. (2011) further revealed that δT3 reduced TC and LDL-C besides suppressing the lipid elevating effects of dexamethasone and potentiated the TG-lowering effect of riboflavin [50]. Using genetically hypercholesterolemic swine, Qureshi et al. (1991) demonstrated the significant effect of TRF in lowering serum TC, LDL-C, Apo-B, thrombo...

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The Role of Vitamin E in Preventing and Treating Osteoarthritis – A Review of the Current Evidence

Cited by 62 publications

References 65 publications

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

Icariin alleviates osteoarthritis by inhibiting NLRP3-mediated pyroptosis

Avocado–Soybean Unsaponifiables: A Panoply of Potentialities to Be Exploited

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

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