The role of vitamins and nutrients in rosacea

Abstract

Rosacea is a common inflammatory skin condition displaying symptoms like flushing, erythema, papules, and pustules. Oral antibiotics, despite long-term adverse effects, are often used due to topical treatment limitations, underscoring the need for cost-effective choices like dietary modifications. Our review investigates the role of vitamins and minerals in rosacea, and provides evidence-based recommendations for supplementation and topical treatment of these nutrients for rosacea. An online search was performed on PubMed, Web of Science, Science Direct, Google Scholar, and ClinicalTrials.gov from 1998 to 2023. Included studies were summarized and assessed for quality and relevance in rosacea management. Varied outcomes emerged concerning the impact of essential vitamins and minerals on rosacea treatment. Vitamin A derivatives, specifically oral isotretinoin, demonstrated significant efficacy, with a 90% reduction in lesions, complete remission in 24% of patients, and marked improvement in 57% of patients. Vitamin B3 derivatives, such as topical 1-methylnicotinamide 0.25% and NADH 1%, improved symptoms in 76.4% (26/34) and 80% of patients, respectively. Outcomes for vitamin D, vitamin C, and zinc supplementation varied across studies. However, zinc sulfate solution 5% significantly reduced acne rosacea severity for patients with 40% and 60% exhibiting a moderate or good response, respectively. Omega-3 fatty acids showed significant improvement in alleviating xerophthalmia in 64% of patients with ocular rosacea. Vitamins and minerals hold potential in managing rosacea symptoms, offering a safe and cost-effective alternative or adjunctive treatment option. Currently, there are no established recommendations regarding their supplementation for rosacea. Studies assessing serum levels of vitamins and minerals in relation to rosacea are warranted, as this avenue holds potential for future advancements in the field.

Metal–Polyphenol–Collagen Self-Assembled Bioadhesive with Immune Regulation for Infected Wound Healing

“…As mentioned above, Zn 2+ has been reported to exert the functions of convergence, antibacterial activity, and accelerating the wound healing process . In our study, zinc sulfate (ZnSO 4 ) is selected as the source and supplement of Zn 2+ , and oral ZnSO 4 has been considered as a simple, effective, and safe option for the treatment of diseases related to zinc deficiency such as chronic ulcer and conjunctivitis . Therefore, the application of ZnSO 4 might be biocompatible within a certain concentration range.…”

“…16 In our study, zinc sulfate (ZnSO 4 ) is selected as the source and supplement of Zn 2+ , and oral ZnSO 4 has been considered as a simple, effective, and safe option for the treatment of diseases related to zinc deficiency such as chronic ulcer and conjunctivitis. 25 Therefore, the application of ZnSO 4 might be biocompatible within a certain concentration range. The other two components of ColTA-Zn, both Col-II and TA, are naturally occurring substances derived from the cartilage extracellular matrix and the bark or fruit of plants, respectively.…”