The role of water in deep eutectic solvent-base extraction

Vilková, Mária; Płotka‐Wasylka, Justyna; Andruch, Vasiľ

doi:10.1016/j.molliq.2020.112747

Cited by 180 publications

(83 citation statements)

References 63 publications

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“…However, caution is required before reaching a final conclusion on the actual improvement of the SWE extraction process by adding DES/NADES as a co-solvent. Namely, as described in the previous sections, excessive water content could break the hydrogen bonds between the DES components and the composite material could lose its eutectic character [78]. The first question that arises is, therefore, whether the increase in the yield of the extraction process is actually due to the influence of the presence of eutectics.…”

Section: New Trends In Extractions Of Bioactive Compoundsmentioning

confidence: 98%

“…The viscosities and densities of DES/NADES solvents can be significantly reduced by adding water. However, the addition of water to the DES/NADES system should be done with caution, as a large excess of water could break the hydrogen bonds between the components and thus lose the eutectic properties of the solvent produced [78]. This is probably the reason why researchers have focused on optimizing the addition of water in the extraction process, usually by testing a content between 0% and 70% [68,71,[79][80][81].…”

Section: Short Historical Overview Of Development and Use Of Des/nadesmentioning

confidence: 99%

“…In most of these studies a water content between 20% and 40% was determined as the optimum. The systematic overview of the interaction between water and DES/NADES is presented in the contributions of El Achkar et al [73] and Vilkova et al [78].…”

Section: Short Historical Overview Of Development and Use Of Des/nadesmentioning

confidence: 99%

See 2 more Smart Citations

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

124

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The growing interest of the food, pharmaceutical and cosmetics industries in naturally occurring bioactive compounds or secondary plant metabolites also leads to a growing demand for the development of new and more effective analysis and isolation techniques. The extraction of bioactive compounds from plant material has always been a challenge, accompanied by increasingly strict control requirements for the final products and a growing interest in environmental protection. However, great efforts have been made in this direction and today a considerable number of innovative extraction techniques have been developed using green, environmentally friendly solvents. These solvents include the deep eutectic solvents (DES) and their natural equivalents, the natural deep eutectic solvents (NADES). Due to their adjustable physical-chemical properties and their green character, it is expected that DES/NADES could be the most widely used solvents in the future, not only in extraction processes but also in other research areas such as catalysis, electrochemistry or organic synthesis. Consequently, this review provided an up-to-date systematic overview of the use of DES/NADES in combination with innovative extraction techniques for the isolation of bioactive compounds from various plant materials. The topicality of the field was confirmed by a detailed search on the platform WoS (Web of Science), which resulted in more than 100 original research papers on DES/NADES for bioactive compounds in the last three years. Besides the isolation of bioactive compounds from plants, different analytical methods are presented and discussed.

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Section: New Trends In Extractions Of Bioactive Compoundsmentioning

confidence: 98%

Section: Short Historical Overview Of Development and Use Of Des/nadesmentioning

confidence: 99%

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Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Ivanović

Razboršek

Kolar

2020

Plants

124

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“…The optimization of this dilution process was performed with different ChCl-LA1/water ratios (v/v = 4/1, 2/1 and 1/1). Higher water contents were not tested because a large excess of water could break the hydrogen bonds between the NADES components and lose the eutectic property of the solvents produced, as observed by others [43,44]. In addition, the increase in temperature results in a) the decrease in the viscosity of the solvent, b) the decrease in the surface tension and c) the increase in the diffusion of analytes into the solvent.…”

Section: Preparation Of Nadessmentioning

confidence: 99%

Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia melanocarpa)

et al. 2020

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For the isolation of selected phenolic compounds from dried chokeberries, natural deep eutectic solvents (NADESs) were investigated as a green alternative to conventionally used extraction solvents. Four types of NADESs were synthesised, with choline chloride as the hydrogen bond acceptor in combination with different hydrogen bond donors (sugars, organic acid and urea). Ultrasound-assisted extraction was used to improve the extractability of the phenolic compounds and the results were compared to those obtained with 80% methanol as the extraction media. The highest values of total phenols and total flavonoids were found in the extract obtained with choline chloride–fructose NADES (36.15 ± 3.39 mg gallic acid g−1 dry weight (DW) and 4.71 ± 0.33 mg rutin g−1 DW, respectively). The extraction recoveries for the individual phenolic compounds depended strongly on the phenolic compound’s structure, with relative mean values between 70% and 97%.

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“…The high viscosity of DESs constitutes severe obstacles for their implementation in industry, even though the fluidity of these solvents might be increased by adding some quantities of water [ 28 ]. Therefore, the hydrophilic DESs have been developed, and the effects of water on their structure, as well as properties have been investigated [ 35 , 36 , 37 , 38 , 39 , 40 ]. For the extraction of polyphenolic compounds, diverse water contents either as a molar ratio or as a percentage have been reported [ 30 , 41 , 42 , 43 , 44 , 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

et al. 2020

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: Deep eutectic solvents (DESs) have got huge interest as new green and sustainable solvents for the extraction of bioactive compounds from plants in recent decades. In the present study, we aimed to investigate the effectiveness of hydrophilic DES for the extraction of anthocyanin and polyphenol antioxidants from Roselle. A natural hydrophilic DES constituted of sodium acetate (hydrogen bond acceptor) and formic acid (hydrogen bond donor) designed to evaluate the total phenolic compound (TPC), total flavonoid (TFC), total anthocyanin (TACN), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging and ferric reducing antioxidant power (FRAP) values of Roselle. Distilled water, 70% ethanol, and 80% methanol used as conventional solvents for comparison. The results indicated that the DES prepared in molarity ratio (SAFAm) was the most efficient. Subsequently, this prominent DES selected for the optimization and the optimum extraction conditions were 1:3.6 molarity ratio, 0% additional water, and 10 mL solvent. TPC, TFC, TACN, FRAP, and DPPH radical scavenging at the optimum point were 233.26 mg GAE/g, 10.14 mg ECE/g, 10.62 mg D3S/g, 493.45 mmol ISE/g, and 343.41 mmol TE/g, respectively. The stability tests showed that anthocyanins were more stable in SAFAm. These findings revealed that SAFAm is an effective green solvent for the extraction of polyphenols from various plants.

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The role of water in deep eutectic solvent-base extraction

Cited by 180 publications

References 63 publications

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Innovative Extraction Techniques Using Deep Eutectic Solvents and Analytical Methods for the Isolation and Characterization of Natural Bioactive Compounds from Plant Material

Choline Chloride Based Natural Deep Eutectic Solvents as Extraction Media for Extracting Phenolic Compounds from Chokeberry (Aronia melanocarpa)

Recovery and Stabilization of Anthocyanins and Phenolic Antioxidants of Roselle (Hibiscus sabdariffa L.) with Hydrophilic Deep Eutectic Solvents

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