The role of whole blood viscosity in premature coronary artery disease in women

Backer, Tine De; Buyzere, Marc De; Segers, Patrick; Carlier, Stéphane; Sutter, Johan De; Wiele, C. Van de; Backer, Guy De

doi:10.1016/s0021-9150(02)00281-2

Cited by 23 publications

(9 citation statements)

References 34 publications

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“…Numerous studies have documented increased rates of stroke and MI in individuals with elevated blood viscosity (9 -13). Because multiple traditional cardiovascular risk factors such as age, male sex, obesity, hypertension, diabetes, and smoking are all associated with increased viscosity, the correlation between viscosity and atherothrombotic events decreases after adjustment for these risk factors (9,14). However, there may be an additional, independent increase in risk for such events associated with high blood viscosity itself (12,13,15).…”

Section: Introductionmentioning

confidence: 99%

Whole blood viscosity and arterial thrombotic events in patients with systemic lupus erythematosus

Booth¹,

Chohan²,

Curran³

et al. 2007

Arthritis & Rheumatism

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Objective. To determine if whole blood viscosity (WBV), a rheologic variable contributing to risk of myocardial infarction and stroke in the general population, is elevated in patients with systemic lupus erythematosus (SLE), particularly SLE patients with a history of thrombotic or atherothrombotic events. Because the high rates of arterial and venous thrombosis in lupus cannot be explained by traditional risk factors, elevated WBV may be an easily measurable nontraditional risk factor to identify SLE patients at high risk for thrombotic events. Methods. Sixty SLE patients (30 with a history of a thrombotic event) and 20 matched controls were recruited into the study. The thrombosis group was further subdivided into an arterial thrombosis group (n ‫؍‬ 17). WBV values were determined at 9 different shear rates (1, 2, 5, 10, 50, 100, 150, 300, and 1,000 seconds ؊1 ). WBV was then compared between groups by repeated-measures analysis of variance. Results. SLE patients with a history of arterial events had significantly elevated WBV relative to either controls (P ‫؍‬ 0.022) or SLE patients without arterial events (P ‫؍‬ 0.014). WBV in the total SLE group did not differ from controls. Differences in WBV were most prominent at lower shear rates (1, 2, 5, 10, 50, and 100 seconds ؊1 ). Anticoagulation, prednisone dose, and antiphospholipid antibodies did not significantly impact WBV. Conclusion. Our study demonstrated that WBV is selectively elevated in patients with SLE with a history of arterial events. Although this association is striking, longitudinal studies are needed to assess the positive predictive value of WBV for atherothrombotic events in SLE.

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Section: Introductionmentioning

confidence: 99%

Whole blood viscosity and arterial thrombotic events in patients with systemic lupus erythematosus

Booth¹,

Chohan²,

Curran³

et al. 2007

Arthritis & Rheumatism

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“…Since then, a number of studies have focused on the importance of this measure with regard to both age and disease status. 6,[18][19][20][21][22] In our sample of apparently healthy adults, blood viscosity was not significantly correlated with any of the risk factors for cardiovascular disease, including age. While some studies have found a positive correlation between blood viscosity and certain cardiovascular disease risk factors, [5][6][7][8]22 others have not.…”

Section: Discussionmentioning

confidence: 99%

“…Whole blood viscosity is determined by hematocrit, plasma viscosity, aggregation of red blood cells, and deformability of red blood cells. 18 It was not until the 1960s that the ability to measure blood viscosity drastically improved and became considered a component of blood flow. Since then, a number of studies have focused on the importance of this measure with regard to both age and disease status.…”

Section: Discussionmentioning

confidence: 99%

“…While some studies have found a positive correlation between blood viscosity and certain cardiovascular disease risk factors, [5][6][7][8]22 others have not. 18,21 Similarly, the relation between aging and blood viscosity is highly debated within the literature. Some studies have found an increase in blood viscosity with age, 20,23,24 whereas others, like the present study, have failed to discover similar findings.…”

Section: Discussionmentioning

confidence: 99%

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Contribution of blood viscosity in the assessment of flow-mediated dilation and arterial stiffness

et al. 2012

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Flow-mediated dilation (FMD) is a non-invasive index of endothelial function. In an attempt to standardize FMD for shear stimulus, shear rate (velocity/diameter), rather than shear stress (viscosity*velocity/diameter), is commonly used as a surrogate measure, although it is limited by individual differences in blood viscosity. The purpose of this study was to determine the contribution of whole blood viscosity to FMD and other key measures of vascular function. Blood viscosity, FMD, carotid artery compliance, and carotid-femoral pulse wave velocity (cfPWV) were measured in 98 apparently healthy adults varying widely in age (18-63 years). Whole blood viscosity was not significantly correlated with FMD, cfPWV, or carotid artery compliance. Shear rate was a stronger correlate with FMD than shear stress that takes blood viscosity into account (r = 0.43 vs 0.28). No significant differences were observed between whole blood viscosity and traditional risk factors for cardiovascular disease. Age was positively correlated with cfPWV (r = 0.65, p < 0.001) and negatively correlated with FMD (r = -0.24, p < 0.05) and carotid artery compliance (r = -0.45, p < 0.01). Controlling for viscosity did not reduce the strength of these relations. These results indicate that whole blood viscosity does not significantly impact measures of vascular function and suggests that the common practice to use shear rate, rather than shear stress, in the adjustment of FMD is valid.

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“…A hemorheologic alteration seem to increase arterial and venous thrombosis risk [13,14,20,21,31], nevertheless, Vaya does not support the former issue [36,37].…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte aggregation in patients with systemic lupus erythematosus

Spengler

Svetaz

Leroux³

et al. 2011

Clinical Hemorheology and Microcirculation

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Systemic Lupus Erythematosus (SLE) is an autoimmune, chronic inflammatory, non-organ specific disease. SLE patients present a high prevalence of thrombotic and arteriosclerotic disease. The aim of the present work was to study the erythrocyte aggregation kinetics, and the effect of plasma factors, namely, immunoglobulin and fibrinogen concentration, as well as cell factors such as deformability and erythrocyte membrane lipid fluidity on the erythrocyte aggregation, in SLE patients and healthy controls. The results show that SLE patients red blood cells aggregate at higher rate and the aggregates size are also greater than controls due to an increase of immunoglobulin and plasma fibrinogen. The negative correlation between aggregation parameters and rigidity index could point out that the altered deformability diminishes the erythrocyte aggregation. Correlation between rigidity index and anisotropy suggests that the decrease of membrane lipid fluidity might be a cause of deformability decrease. The erythrocyte aggregation increase in these patients could induce a decreased flow that might contribute to the thromboembolic process present in SLE patients.

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The role of whole blood viscosity in premature coronary artery disease in women

Cited by 23 publications

References 34 publications

Whole blood viscosity and arterial thrombotic events in patients with systemic lupus erythematosus

Whole blood viscosity and arterial thrombotic events in patients with systemic lupus erythematosus

Contribution of blood viscosity in the assessment of flow-mediated dilation and arterial stiffness

Erythrocyte aggregation in patients with systemic lupus erythematosus

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