The prevalence and severity of Covid 2019 has brought to light new vulnerabilities of Health Care Workers (HCWs) in their working conditions, social protection, and occupational safety and mental health. In view of this, our paper aimed to provide comprehensive analysis of psychological stress, socio-economic impact, government intervention, interpersonal relations, work-life balance, and coping strategies of HCWs during the pandemic time in India. Based on data collected physically from 606 HCWs working in seven hospitals located in Delhi-NCR using structured questionnaires, six latent variables were constructed. T-test and ANOVA technique along with Post-hoc analysis was used to make comparisons and identify groups across which significant differences existed. Further, a two-group discriminant analysis was performed to find the variables that best discriminated between HCWs from private or public hospitals and medically or not-medically trained. Lastly, chi-squared (χ²) test was performed to examine the statistical association between coping strategies and few demographic characteristics. The results revealed that females and medically-trained HCWs were more psychologically stressed than their counterparts. Work-life-balance and interpersonal relations were found to be more disturbed among the medically-trained HCWs. Government regulations favourably affected the non-medically trained and HCWs with children and elderlies. Additionally, the impact of interpersonal relationships and work-life-balance was found to be adverse on permanent HCWs. Discriminant analysis showed that interpersonal relationships, followed by government intervention, work-life balance and socio-economic impact were the most important predictors between medically and non-medically trained HCWs. However, none of these factors discriminated between HCWs from private or public hospitals. Further, the preference patterns of coping strategies suggested that HCWs worked with an optimistic state of mind and adopted positive techniques. To make the healthcare system more resilient, it is strongly suggested that the government should play a key role during the times of pandemic, especially-encompassing females and financially stressed categories of HCWs.