The Role of Y-Box Binding Protein 1 in Kidney Injury: Friend or Foe?

Ke, Ben; Fan, Chuqiao; Tu, Wei; Fang, Xiangdong

doi:10.1159/000488432

Cited by 5 publications

(1 citation statement)

References 56 publications

(77 reference statements)

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“…Moreover, cold shock proteins containing a CSD are not solely restricted to prokaryotes but are also identified in eukaryotes with the presence of auxiliary domains in addition to one or more CSDs [15][16][17][18]. Here, they are not confined to the cold shock response but serve pleiotropic functions in the cell [19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

From Stress Tolerance to Virulence: Recognizing the Roles of Csps in Pathogenicity and Food Contamination

Cardoza,

Singh

2024

Pathogens

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Be it for lab studies or real-life situations, bacteria are constantly exposed to a myriad of physical or chemical stresses that selectively allow the tolerant to survive and thrive. In response to environmental fluctuations, the expression of cold shock domain family proteins (Csps) significantly increases to counteract and help cells deal with the harmful effects of stresses. Csps are, therefore, considered stress adaptation proteins. The primary functions of Csps include chaperoning nucleic acids and regulating global gene expression. In this review, we focus on the phenotypic effects of Csps in pathogenic bacteria and explore their involvement in bacterial pathogenesis. Current studies of csp deletions among pathogenic strains indicate their involvement in motility, host invasion and stress tolerance, proliferation, cell adhesion, and biofilm formation. Through their RNA chaperone activity, Csps regulate virulence-associated genes and thereby contribute to bacterial pathogenicity. Additionally, we outline their involvement in food contamination and discuss how foodborne pathogens utilize the stress tolerance roles of Csps against preservation and sanitation strategies. Furthermore, we highlight how Csps positively and negatively impact pathogens and the host. Overall, Csps are involved in regulatory networks that influence the expression of genes central to stress tolerance and virulence.

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