The role of zinc in caspase activation and apoptotic cell death

Truong-Tran, Ai Q.; Carter, Joanne; Ruffin, Richard E.; Zalewski, Peter D.

doi:10.1007/978-94-017-3728-9_7

Cited by 123 publications

(159 citation statements)

References 96 publications

Supporting

Mentioning

152

Contrasting

Unclassified

Order By: Relevance

“…Dysregulation in apoptosis influences the pathogenesis of many diseases such as AIDS, diabetes mellitus, autoimmune diseases, malignancies and most prominently, neurodegenerative disorders. Thus, understanding the regulatory factors involved in this process is crucial for developing therapeutic strategies [47]. There are several conflicting results showing how zinc can be anti-or pro-apoptotic depending on the zinc concentration used.…”

Section: A Nf-κb and Other Signalling Pathwaymentioning

confidence: 99%

Zinc in Infection and Inflammation

Gammoh¹,

Rink²

2017

Preprint

187

139

View full text Add to dashboard Cite

Abstract:Micronutrient homeostasis is a key factor in maintaining a healthy immune system. Zinc is an essential micronutrient that is involved in the regulation of the innate and adaptive immune responses. The main cause of zinc deficiency is malnutrition. Zinc deficiency leads to cell-mediated immune dysfunctions among other manifestations. Consequently, such dysfunctions lead to a worse outcome in the response towards bacterial infection and sepsis. For instance, zinc is an essential component of the pathogen-eliminating signal transduction pathways leading to neutrophil extracellular traps formation, as well as inducing cell-mediated immunity over humoral immunity by regulating specific factors or differentiation. Additionally, zinc deficiency plays a role in inflammation, mainly elevating inflammatory response as well as damage to host tissue. Zinc is involved in the modulation of the proinflammatory response by targeting Nuclear Factor Kappa B, a transcription factor that is the master regulator of proinflammatory responses. It is also involved in controlling oxidative stress and regulating inflammatory cytokines. Zinc plays an intricate function during an immune response and its homeostasis is critical for sustaining proper immune function. This review will summarize the latest findings concerning the role of this micronutrient during the course of infections and inflammatory response and how the immune system modulates zinc depending on different stimuli.

show abstract

Section: A Nf-κb and Other Signalling Pathwaymentioning

confidence: 99%

Zinc in Infection and Inflammation

Gammoh¹,

Rink²

2017

Preprint

187

139

View full text Add to dashboard Cite

show abstract

“…[18] In this context, ZnO NPs have attracted attention as antimicrobials [19,20] and UV blockers, [21] among others. Moreover, zinc is an essential element for cells, which acts as an intracellular secondary messenger in different cellular processes, [22,23] in particular, the lack of zinc can inhibit myoblast differentiation. [24,25] More recently has been shown that zinc promotes myoblast proliferation and differentiation via the activation of the ERK/Akt signalling cascade.…”

Section: Introductionmentioning

confidence: 99%

PLLA/ZnO nanocomposites: Dynamic surfaces to harness cell differentiation

Trujillo

Lizundia

Vilas

et al. 2016

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Graphical abstract2 Highlights  Biodegradable poly(L-lactide) matrix loaded with ZnO nanorods. Dynamic presentation of nanorods triggered by PLLA degradation. Changes in surface properties as a function of time control cell behaviour. Nanorods exposure promotes cell differentiation.3 Keywords: PLLA, ZnO nanoparticle, C2C12 myoblast, nanocomposite, cell differentiation AbstractThis work investigates the effect of the sequential availability of ZnO nanoparticles, (nanorods of ~ 20 nm) loaded within a degradable poly(lactic acid) (PLLA) matrix, in cell differentiation. The system constitutes a dynamic surface, in which nanoparticles are exposed as the polymer matrix degrades. ZnO nanoparticles were loaded into PLLA and the system was measured at different time points to characterise the time evolution of the physicochemical properties, including wettability and thermal properties. The micro and nanostructure were also investigated using AFM, SEM and TEM images. Cellular experiments with C2C12 myoblasts show that cell differentiation was significantly enhanced on ZnO nanoparticles -loaded PLLA, as the polymer degrades and the availability of nanoparticles become more apparent, whereas the release of zinc within the culture medium was negligible. Our results suggest PLLA/ZnO nanocomposites can be used as a dynamic system where nanoparticles are exposed during degradation, activating the material surface and driving cell differentiation.4

show abstract

“…A variety of studies indicate that, depending on its concentration, zinc can either be pro-or anti-apoptotic, and both zinc deprivation and excess can induce apoptosis in the same cell line Formigari et al 2007;Cummings and Kovacic 2009). The induction of apoptosis by high levels of intracellular zinc has been shown in different tissues and cell types (Truong-Tran et al 2001;Watjen et al 2002). Reports indicate that accumulation of intracellular zinc, as a consequence of either exogenous administration or release from intracellular stores by reactive oxygen species or nitrosation, activates pro-apoptotic molecules like p38 and potassium channels, leading to cell death (Kim et al 1999;McLaughlin et al 2001;TruongTran et al 2001).…”

Section: Discussionmentioning

confidence: 99%

Transient receptor potential melastatin type 7 channels are involved in zinc-induced apoptosis in gastric cancer

Kim¹

2011

Animal Cells and Systems

View full text Add to dashboard Cite

The role of zinc in caspase activation and apoptotic cell death

Cited by 123 publications

References 96 publications

Zinc in Infection and Inflammation

Zinc in Infection and Inflammation

PLLA/ZnO nanocomposites: Dynamic surfaces to harness cell differentiation

Transient receptor potential melastatin type 7 channels are involved in zinc-induced apoptosis in gastric cancer

Contact Info

Product

Resources

About