The role of zinc in the biocorrosion behavior of resorbable Mg‒Zn‒Ca alloys

Cihova, Martina; Martinelli, Elisabeth; Schmutz, Patrik; Myrissa, Anastasia; Schäublin, R.; Weinberg, Annelie; Uggowitzer, Peter J.; Löffler, Jörg F.

doi:10.1016/j.actbio.2019.09.021

Cited by 73 publications

(46 citation statements)

References 50 publications

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“…The concentration of Zn 2+ and Sr 2+ in the blood and organs of the Zn-0.8Sr group was not higher than the pure Ti implant group [22] 54 rats, From the aforementioned studies, which were analysed in detail and whose results are summarized in Table 1, magnesium can be characterized as having very good biocompatibility with the surrounding bone-expressed by good new-bone production, good osteoconductivity and osteoinductivity, and good mechanical properties [2,3,27,28,30]. In the case of pure magnesium, hydrogen pockets were often formed [2,28,29]. Those gas pockets did not interfere with normal bone healing or lead to any significant inflammation or necrosis of the surrounding soft tissues [3,28,29].…”

Section: Introductionmentioning

confidence: 99%

Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

et al. 2021

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In this pilot study, we investigated the biocompatibility and degradation rate of an extruded Zn–0.8Mg–0.2Sr (wt.%) alloy on a rabbit model. An alloy screw was implanted into one of the tibiae of New Zealand White rabbits. After 120 days, the animals were euthanized. Evaluation included clinical assessment, microCT, histological examination of implants, analyses of the adjacent bone, and assessment of zinc, magnesium, and strontium in vital organs (liver, kidneys, brain). The bone sections with the implanted screw were examined via scanning electron microscopy and energy dispersive spectroscopy (SEM-EDS). This method showed that the implant was covered by a thin layer of phosphate-based solid corrosion products with a thickness ranging between 4 and 5 µm. Only negligible changes of the implant volume and area were observed. The degradation was not connected with gas evolution. The screws were fibrointegrated, partially osseointegrated histologically. We observed no inflammatory reaction or bone resorption. Periosteal apposition and formation of new bone with a regular structure were frequently observed near the implant surface. The histological evaluation of the liver, kidneys, and brain showed no toxic changes. The levels of Zn, Mg, and Sr after 120 days in the liver, kidneys, and brain did not exceed the reference values for these elements. The alloy was safe, biocompatible, and well-tolerated.

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Section: Introductionmentioning

confidence: 99%

Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

et al. 2021

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“…More details on materials synthesis and processing can be found in Refs. [23, 29]. Pins of 1.6 mm diameter and 8 mm length were then machined using polycrystalline diamond tools, taking special care to avoid any kind of surface contamination.…”

Section: Experimental Section/methodsmentioning

confidence: 99%

“…ZX10 contains intermetallic precipitates (IMPs) on the nanoscale, which governs its degradation behaviour and leads to improved mechanical properties. Its detailed biodegradation behaviour [23] and its susceptibility to stress-corrosion cracking and corrosion fatigue [24] has been studied in vitro in simulated physiological environment and its response to bone has also been documented recently via a long-term in vivo study [23].…”

Section: Introductionmentioning

confidence: 99%

3D nanoscale analysis of bone healing around degrading Mg implants studied by X-ray scattering tensor tomography

Liebi

Lutz‐Bueno

Guizar‐Sicairos

et al. 2020

Preprint

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The nanostructural adaptation of bone is crucial for its compatibility with orthopedic implants. The bone’s nanostructure determines its mechanical properties, however little is known about its temporal and spatial adaptation in degrading implants. This study presents insights into this adaptation by applying electron microscopy, elemental analysis, and small-angle X-ray scattering tensor-tomography (SASTT). We extend the SASTT reconstruction to multiple radii of the reciprocal space vector q, providing a 3D reciprocal-space map per voxel. Each scattering curve is spatially linked to one voxel in the volume, and properties such as the thickness of the mineral particles are quantified. This reconstruction provides information on nanostructural adaptation during healing around a degrading ZX10 magnesium implant over the course of 18 months, using a sham as control. The nanostructural adaptation process is observed to start with an initially fast interfacial organization towards the implant direction, followed by a substantial reorganization of the volume around the implant, and an adaptation in the later degradation stages. The study sheds light on the complex bone-implant interaction in 3D, allowing a more guided approach towards the design of future implant materials, which are expected to be of great interest for further clinical studies on the bone-implant interaction.TOC text and figureDegrading Magnesium implants are mechanically and chemically well adapted orthopedic implant materials and ensure a gradual load transfer during bone healing due to their degradation. The impact of the implant degradation on the bone nanostructure is however not fully understood. This study unveils the processes 3D and shows different stages of bone healing.

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“…The Mg-Zn-Ca alloys belong to the prospective metallic biomaterials due to their biocompatibility, biodegradability [1,2] and the Young's modulus of the alloys being close to that of bones [3]. A low amount of alloying elements reduces production costs, and thus increases economic efficiency.…”

Section: Introductionmentioning

confidence: 99%

Grain Size-Related Strengthening and Softening of a Precompressed and Heat-Treated Mg–Zn–Ca Alloy

et al. 2020

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The impact of precompression, thermal treatment and its combination on the deformation behaviour of an extruded Mg–Zn–Ca (ZX10) alloy was studied with respect to a varied average grain size. The Hall–Petch plot was used to highlight the impact in a wide grain size interval. The initial texture of the wrought alloy was characterized by X-ray diffraction. Moreover, the evolution of microstructure and texture was provided by the electron backscatter diffraction (EBSD) technique. The obtained results indicate the strong contribution of deformation-thermal treatment on the resulting deformation behaviour. Particularly, after precompression and heat treatment, higher strengthening effect was observed in the reversed tensile loaded compared to compressed samples without any change in the Hall–Petch slope throughout the grain size interval. Unlike this strengthening effect, a reversed tension–compression yield asymmetry with higher strength values in compression has been obtained.

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The role of zinc in the biocorrosion behavior of resorbable Mg‒Zn‒Ca alloys

Cited by 73 publications

References 50 publications

Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

Zn–0.8Mg–0.2Sr (wt.%) Absorbable Screws—An In-Vivo Biocompatibility and Degradation Pilot Study on a Rabbit Model

3D nanoscale analysis of bone healing around degrading Mg implants studied by X-ray scattering tensor tomography

Grain Size-Related Strengthening and Softening of a Precompressed and Heat-Treated Mg–Zn–Ca Alloy

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