The role of zinc in follicular development

Liao, Xingyue; Wu, Liujianxiong; Yin, Dan; Tian, Dewei; Zhou, Cuilan; Liu, Jun; Li, Suyun; Zhou, Jing; Nie, Yulin; Liao, Hongjian; Peng, Cuiying

doi:10.1007/s11033-023-08331-6

Cited by 3 publications

(6 citation statements)

References 73 publications

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“…Previous studies have shown that metal metabolites, such as cadmium (Cd) [ 36 ], iron (Fe) [ 37 , 38 ], copper (Cu) [ 39 ], lead (Pb) [ 40 ], and zinc (Zn) [ 41 ], play key roles in gonadal development, germ cell growth and maturation, and reproduction in mammals and fish. In our study, functional enrichment analysis of the DEPs focused on metal metabolite-related pathways and terms, such as Cu 2+ -, Ca 2+ -, Zn 2+ - and Fe 2+ /Fe 3+ -related pathways and terms.…”

Section: Discussionmentioning

confidence: 99%

“…In contrast, the content of Zn 2+ showed a trend of increasing, then decreasing, and then increasing again, and was the highest in the IE period, indicating that zinc ions have an important role in the process from OV to IM. Zn is an essential nutrient involved in many physiological processes, such as follicular development, immune response, homeostasis, oxidative stress, cell cycle progression, DNA replication, DNA damage repair, apoptosis, and aging [ 41 ]. Zn deficiency could lead to blocking the oocyte meiotic process, cumulus expansion, and follicle ovulation [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

“…Zn is an essential nutrient involved in many physiological processes, such as follicular development, immune response, homeostasis, oxidative stress, cell cycle progression, DNA replication, DNA damage repair, apoptosis, and aging [ 41 ]. Zn deficiency could lead to blocking the oocyte meiotic process, cumulus expansion, and follicle ovulation [ 41 ]. In flounder ( Pseudopleuronectes americanus ), females stored Zn in summer for winter gonadal development [ 49 ].…”

Section: Discussionmentioning

confidence: 99%

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Protein expression patterns and metal metabolites in a protogynous hermaphrodite fish, the ricefield eel (Monopterus albus)

He,

Xiao,

Yang

et al. 2024

BMC Genomics

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Background The ricefield eel Monopterus albus undergoes a natural sex change from female to male during its life cycle, and previous studies have shown the potential mechanisms of this transition at the transcriptional and protein levels. However, the changes in protein levels have not been fully explored, especially in the intersexual stage. Results In the present study, the protein expression patterns in the gonadal tissues from five different periods, the ovary (OV), early intersexual stage gonad (IE), middle intersexual stage gonad (IM), late intersexual stage gonad (IL), and testis (TE), were determined by untargeted proteomics sequencing. A total of 5125 proteins and 394 differentially expressed proteins (DEPs) were detected in the gonadal tissues. Of the 394 DEPs, there were 136 between the OV and IE groups, 20 between the IM and IE groups, 179 between the IL and IM groups, and 59 between the TE and IL groups. Three candidate proteins, insulin-like growth factor 2 mRNA-binding protein 3 isoform X1 (Igf2bp3), triosephosphate isomerase (Tpi), and Cu-Zn superoxide dismutase isoform X1 [(Cu-Zn) Sod1], were validated by western blotting to verify the reliability of the data. Furthermore, metal metabolite-related proteins were enriched in the IL vs. IM groups and TE vs. IL groups, which had close relationships with sex change, including Cu2+-, Ca2+-, Zn2+- and Fe2+/Fe3+-related proteins. Analysis of the combined transcriptome data revealed consistent protein/mRNA expression trends for two metal metabolite-related proteins/genes [LOC109953912 and calcium Binding Protein 39 Like (cab39l)]. Notably, we detected significantly higher levels of Cu2+ during the sex change process, suggesting that Cu2+ is a male-related metal metabolite that may have an important function in male reproductive development. Conclusions In summary, we analyzed the protein profiles of ricefield eel gonadal tissues in five sexual stages (OV, IE, IM, IL, and TE) and verified the plausibility of the data. After preforming the functional enrichment of metal metabolite-related DEPs, we detected the contents of the metal metabolites Zn2+, Cu2+, Ca2+, and Fe2+/Fe3+ at these five stages and screened for (Cu-Zn) Sod1 and Mmp-9 as possible key proteins in the sex reversal process.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Protein expression patterns and metal metabolites in a protogynous hermaphrodite fish, the ricefield eel (Monopterus albus)

He,

Xiao,

Yang

et al. 2024

BMC Genomics

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“…Numerous scientific investigations have highlighted that zinc deficiency can significantly perturb follicular development, a critical process wherein the oocyte matures within a protective sac of granulosa cells [88,94,218]. Disruptions in this complicated process, due to a zinc deficiency (Tian and Diaz 2013), can lead to ovulation disorders, which are characterized by impaired follicle rupture or impaired egg release [219]. Consequently, this diminishes the potential for successful fertilization and implantation [220][221][222].…”

Section: Zincmentioning

confidence: 99%

“…It safeguards the oocytes, which are especially vulnerable to ROS-induced damage during maturation, thereby enhancing the likelihood of successful fertilization [99,272,273]. Concurrently, zinc facilitates the ovulation process by maintaining an ROS balance, promoting a consistent ovulatory cycle [43,219]. Post-fertilization, zinc serves a protective role for the developing embryo against ROS-induced harm, augmenting the prospects for successful implantation and development [44,[274][275][276][277].…”

Section: Influence Of Minerals On Oxidative Stress 421 Zincmentioning

confidence: 99%

Minerals and the Menstrual Cycle: Impacts on Ovulation and Endometrial Health

Kapper,

Oppelt,

Ganhör

et al. 2024

Nutrients

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The role of minerals in female fertility, particularly in relation to the menstrual cycle, presents a complex area of study that underscores the interplay between nutrition and reproductive health. This narrative review aims to elucidate the impacts of minerals on key aspects of the reproductive system: hormonal regulation, ovarian function and ovulation, endometrial health, and oxidative stress. Despite the attention given to specific micronutrients in relation to reproductive disorders, there is a noticeable absence of a comprehensive review focusing on the impact of minerals throughout the menstrual cycle on female fertility. This narrative review aims to address this gap by examining the influence of minerals on reproductive health. Each mineral’s contribution is explored in detail to provide a clearer picture of its importance in supporting female fertility. This comprehensive analysis not only enhances our knowledge of reproductive health but also offers clinicians valuable insights into potential therapeutic strategies and the recommended intake of minerals to promote female reproductive well-being, considering the menstrual cycle. This review stands as the first to offer such a detailed examination of minerals in the context of the menstrual cycle, aiming to elevate the understanding of their critical role in female fertility and reproductive health.

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