The Role of Zinc in Selected Female Reproductive System Disorders

Nasiadek, Marzenna; Stragierowicz, Joanna; Klimczak, Michał; Kilanowicz, Anna

doi:10.3390/nu12082464

Cited by 78 publications

(61 citation statements)

References 108 publications

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“…This was shown in a study that found that zinc significantly lowered the pain duration and severity in women compared to the control group and improved the patients’ quality of life [ 285 ]. One study suggested that daily intake of 30 mg of zinc one to four days prior to menstruation can prevent menstrual cramping pain, without harmful side effects, while another showed evidence that zinc can treat primary dysmenorrhea in adolescent girls [ 286 ].…”

Section: Menstrual Disordersmentioning

confidence: 99%

Nutrition in Gynecological Diseases: Current Perspectives

et al. 2021

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Diet and nutrition are fundamental in maintaining the general health of populations, including women’s health. Health status can be affected by nutrient deficiency and vice versa. Gene–nutrient interactions are important contributors to health management and disease prevention. Nutrition can alter gene expression, as well as the susceptibility to diseases, including cancer, through several mechanisms. Gynecological diseases in general are diseases involving the female reproductive system and include benign and malignant tumors, infections, and endocrine diseases. Benign diseases such as uterine fibroids and endometriosis are common, with a negative impact on women’s quality of life, while malignant tumors are among the most common cause of death in the recent years. In this comprehensive review article, a bibliographic search was performed for retrieving information about nutrients and how their deficiencies can be associated with gynecological diseases, namely polycystic ovary syndrome, infertility, uterine fibroids, endometriosis, dysmenorrhea, and infections, as well as cervical, endometrial, and ovarian cancers. Moreover, we discussed the potential beneficial impact of promising natural compounds and dietary supplements on alleviating these significant diseases.

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Section: Menstrual Disordersmentioning

confidence: 99%

Nutrition in Gynecological Diseases: Current Perspectives

et al. 2021

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“…Zinc plays a role in homeostasis, cell growth, hormone release, immunological responses, and biological reproduction. It also protects cells against reactive oxygen species [ 72 ].…”

Section: Discussionmentioning

confidence: 99%

Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis

et al. 2021

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Backgrounds Polycystic ovary syndrome affects 7% of women of reproductive ages. Poor-quality oocytes, along with lower cleavage and implantation rates, reduce fertilization. Objective This study aimed to determine crucial molecular mechanisms behind PCOS pathogenesis and repurpose new drug candidates interacting with them. To predict a more in-depth insight, we applied a novel bioinformatics approach to analyze interactions between the drug-related and PCOS proteins in PCOS patients. Methods The newest proteomics data was retrieved from 16 proteomics datasets and was used to construct the PCOS PPI network using Cytoscape. The topological network analysis determined hubs and bottlenecks. The MCODE Plugin was used to identify highly connected regions, and the associations between PCOS clusters and drug-related proteins were evaluated using the Chi-squared/Fisher's exact test. The crucial PPI hub-bottlenecks and the shared molecules (between the PCOS clusters and drug-related proteins) were then investigated for their drug-protein interactions with previously US FDA-approved drugs to predict new drug candidates. Results The PI3K/AKT pathway was significantly related to one PCOS subnetwork and most drugs (metformin, letrozole, pioglitazone, and spironolactone); moreover, VEGF, EGF, TGFB1, AGT, AMBP, and RBP4 were identified as the shared proteins between the PCOS subnetwork and the drugs. The shared top biochemical pathways between another PCOS subnetwork and rosiglitazone included metabolic pathways, carbon metabolism, and citrate cycle, while the shared proteins included HSPB1, HSPD1, ACO2, TALDO1, VDAC1, and MDH2. We proposed some new candidate medicines for further PCOS treatment investigations, such as copper and zinc compounds, reteplase, alteplase, gliclazide, Etc. Conclusion Some of the crucial molecules suggested by our model have already been experimentally reported as critical molecules in PCOS pathogenesis. Moreover, some repurposed medications have already shown beneficial effects on infertility treatment. These previous experimental reports confirm our suggestion for investigating our other repurposed drugs (in vitro and in vivo). Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s40199-021-00413-9.

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“…Low zinc intake in obese people is associated with hyperinsulinemia, increased low-grade inflammation, and a worsened lipid profile. In addition, zinc ions can act in an insulin-mimetic manner in adipocytes, stimulating lipogenesis and glucose transport through the translocation of glucose transporter 4 (GLUT4) to the plasma membrane [ 109 ]. Zinc deficiency may play a significant role in the pathogenesis of PCOS and may be a prognostic marker of PCOS.…”

Section: Lifestyle Changesmentioning

confidence: 99%

Nutrition Strategy and Life Style in Polycystic Ovary Syndrome—Narrative Review

et al. 2021

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Here we present an extensive narrative review of the broadly understood modifications to the lifestyles of women with polycystic ovary syndrome (PCOS). The PubMed database was analyzed, combining PCOS entries with causes, diseases, diet supplementation, lifestyle, physical activity, and use of herbs. The metabolic pathways leading to disturbances in lipid, carbohydrate, and hormonal metabolism in targeted patients are described. The article refers to sleep disorders, changes in mental health parameters, and causes of oxidative stress and inflammation. These conditions consistently lead to the occurrence of severe diseases in patients suffering from diabetes, the fatty degeneration of internal organs, infertility, atherosclerosis, cardiovascular diseases, dysbiosis, and cancer. The modification of lifestyles, diet patterns and proper selection of nutrients, pharmacological and natural supplementation in the form of herbs, and physical activity have been proposed. The progress and consequences of PCOS are largely modifiable and depend on the patient’s approach, although we have to take into account also the genetic determinants.

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The Role of Zinc in Selected Female Reproductive System Disorders

Cited by 78 publications

References 108 publications

Nutrition in Gynecological Diseases: Current Perspectives

Nutrition in Gynecological Diseases: Current Perspectives

Repurposing new drug candidates and identifying crucial molecules underlying PCOS Pathogenesis Based On Bioinformatics Analysis

Nutrition Strategy and Life Style in Polycystic Ovary Syndrome—Narrative Review

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