The role of zinc in rosacea and acne: further reflections

Gessert, Charles E.; Bamford, Joel T.M.; Haller, Irina V.; Johnson, Brian P.

doi:10.1111/ijd.12263

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…They found that a 5% zinc sulfate solution significantly reduced the disease severity score in acne rosacea. However, Bamford et al ( 24 ) and Gessert et al ( 75 ) compared zinc sulfate with placebo for rosacea therapy. The results showed that oral zinc sulfate did not significantly improve rosacea severity compared with a placebo and was even less effective than a placebo in these studies.…”

Section: Inflammatory Diseasesmentioning

confidence: 99%

Trace element zinc and skin disorders

Pan

Yang

et al. 2023

Front. Med.

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Zinc is a necessary trace element and an important constituent of proteins and other biological molecules. It has many biological functions, including antioxidant, skin and mucous membrane integrity maintenance, and the promotion of various enzymatic and transcriptional responses. The skin contains the third most zinc in the organism. Zinc deficiency can lead to a range of skin diseases. Except for acrodermatitis enteropathic, a rare genetic zinc deficiency, it has also been reported in other diseases. In recent years, zinc supplementation has been widely used for various skin conditions, including infectious diseases (viral warts, genital herpes, cutaneous leishmaniasis, leprosy), inflammatory diseases (hidradenitis suppurativa, acne vulgaris, rosacea, eczematous dermatitis, seborrheic dermatitis, psoriasis, Behcet's disease, oral lichen planus), pigmentary diseases (vitiligo, melasma), tumor-associated diseases (basal cell carcinoma), endocrine and metabolic diseases (necrolytic migratory erythema, necrolytic acral erythema), hair diseases (alopecia), and so on. We reviewed the literature on zinc application in dermatology to provide references for better use.

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Section: Inflammatory Diseasesmentioning

confidence: 99%

Trace element zinc and skin disorders

Pan

Yang

et al. 2023

Front. Med.

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“…61 However, some studies are beginning to show that omega 3 fatty acids, namely, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), can competitively inhibit proinflammatory pathways, since they are substrates of anti-inflammatory prostaglandins, and that zinc can have antioxidant and anti-inflammatory actions and is essential for the development of the innate immune system. 55,62 However, more studies are needed to prove that these specific nutrients alleviate the symptoms of rosacea. 54 Sun exposure is also a triggering factor for rosacea symptoms and is one of the most common factors for flushing.…”

Section: Preventionmentioning

confidence: 99%

Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems

et al. 2023

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Rosacea is a multifactorial chronic inflammatory dermatosis characterized by flushing, nontransient erythema, papules and pustules, telangiectasia, and phymatous alterations accompanied by itching, burning, or stinging, the pathophysiology of which is not yet fully understood. Conventional topical treatments usually show limited efficacy due to the physical barrier property of the skin that hinders skin penetration of the active ingredients, thereby hampering proper drug skin delivery and the respective therapeutic or cosmetic effects. New advances regarding the physiopathological understanding of the disease and the underlying mechanisms suggest the potential of new active ingredients as promising therapeutic and cosmetic approaches to this dermatosis. Additionally, the development of new drug delivery systems for skin delivery, particularly the potential of nanoparticles for the topical treatment and care of rosacea, has been described. Emphasis has been placed on their reduced nanometric size, which contributes to a significant improvement in the attainment of targeted skin drug delivery. In addition to the exposition of the known pathophysiology, epidemiology, diagnosis, and preventive measures, this Review covers the topical approaches used in the control of rosacea, including skin care, cosmetics, and topical therapies, as well as the future perspectives on these strategies.

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The role of zinc in rosacea and acne: further reflections

Cited by 2 publications

References 8 publications

Trace element zinc and skin disorders

Trace element zinc and skin disorders

Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems

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