The Role Radius of Curvature Plays in Thiolated Oligonucleotide Loading on Gold Nanoparticles

Hill, Haley D.; Millstone, Jill E.; Banholzer, Matthew J.; Mirkin, Chad A.

doi:10.1021/nn800726e

Cited by 452 publications

(570 citation statements)

References 32 publications

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“…A similar film thickness is expected on the AuNPs as on the planar gold substrates (< 3 nm), since curvature effects are relatively small on 15-nm particles. [30] Despite the thin film thickness and the low molecular weight of 2 and 3 they provide excellent steric stabilization, due to their specific anchoring to the nanoparticle surface and favorable interactions with water molecules as was indicated in the IR water absorption bands. The shift in LSPR peak position (<1 nm for both AuNP-2 and AuNP-3) in 5 M NaCl is smaller than expected indicating that ions do not penetrate to a very large extent into the film.…”

Section: Immobilization On Gold Nanoparticlesmentioning

confidence: 99%

Synthesis of oligo(lactose)-based thiols and their self-assembly onto gold surfaces

Fyrner¹,

Ederth²,

Aili³

et al. 2013

Colloids and Surfaces B: Biointerfaces

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Graphical abstract: HighlightsPlanar gold surfaces and gold nanoparticles are functionalized using oligosaccharide terminated alkanethiols. The properties of the SAMs are thoroughly characterized using infrared reflectionabsorption spectroscopy, contact angle goniometry and null-elllipsometry. The colloidal stability of the glyconanoparticles is monitored using UV-vis spectroscopy. AbstractThe ability to produce monomolecular coatings with well-defined structural and functional properties is of key importance in biosensing, drug delivery, and many recently developed applications of nanotechnology. Organic chemistry has proven to be a powerful tool to achieve this in many research areas. Herein, we present the synthesis of three oligo(lactosides) glycosylated in a (1→3) manner, and which are further functionalized with amide-linked short alkanethiol spacers. The oligosaccharides (di-, tetra-, and hexasaccharide) originate from the inexpensive and readily available lactose disaccharide. These thiolated derivatives were immobilized onto gold surfaces, and the thus formed self-assembled monolayers (SAMs) on planar gold were characterized by wettability, ellipsometry and infrared reflection-absorption spectroscopy. Further, the ability of these SAMs to stabilize gold nanoparticles in saline solutions was also demonstrated, indicating that the oligosaccharides may be used as stabilizing agents in gold nanoparticle-based assays.

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Section: Immobilization On Gold Nanoparticlesmentioning

confidence: 99%

Synthesis of oligo(lactose)-based thiols and their self-assembly onto gold surfaces

Fyrner¹,

Ederth²,

Aili³

et al. 2013

Colloids and Surfaces B: Biointerfaces

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“…This modular structure enables researchers to program the length of DNA surface ligands with subnanometer precision based on the number of nucleobases. Control of surface ligand length and orientation is enhanced with double-stranded rather than single-stranded DNA, which increases the persistence length from 2 nm to 50 nm (55), and with increased surface density, wherein the polymer brush effect aligns and extends surface ligands (7,44,48,54,56). Tunable length allows precise control of interparticle spacing in nanoparticle crystallization experiments and sequence specificity allows one to program in chemical complementarity into surface ligands, which can be used to specifically cocrystallize nanoparticles of different sizes, shapes, and compositions (57,58).…”

Section: Ligands Arranged On Nanoparticle Surfacesmentioning

confidence: 99%

The nature and implications of uniformity in the hierarchical organization of nanomaterials

O’Brien

Jones

Mirkin

2016

Proc. Natl. Acad. Sci. U.S.A.

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In this Perspective, we present a framework that defines how to understand and control material structure across length scales with inorganic nanoparticles. Three length scales, frequently discussed separately, are unified under the topic of hierarchical organization: atoms arranged into crystalline nanoparticles, ligands arranged on nanoparticle surfaces, and nanoparticles arranged into crystalline superlattices. Through this lens, we outline one potential pathway toward perfect colloidal matter that emphasizes the concept of uniformity. Uniformity is of both practical and functional importance, necessary to increase structural sophistication and realize the promise of nanostructured materials. Thus, we define the nature of nonuniformity at each length scale as a means to guide ongoing research efforts and highlight potential problems in the field.nanomaterial | uniformity | colloidal crystal | dispersity | hierarchy

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“…Ressine et al (2007) used porous silicon as a scaffold for antibody arrays and obtained detection limits down to 1 picomolar for IgG and 20 picomolar for prostatespecific antigen (PSA) in clinical samples. Hill et al (2009) explored the curvature effect of spherical gold nanoparticles on the loading density of probes. They showed that the binding to the nanoparticle surface is similar to that of a planar structure when the diameter of the particle is greater than 60 nm.…”

Section: Nanostructured Surfacesmentioning

confidence: 99%

Post-Genomics Nanotechnology Is Gaining Momentum: Nanoproteomics and Applications in Life Sciences

Kobeissy

Gülbakan

Alawieh

et al. 2014

OMICS: A Journal of Integrative Biology

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The post-genomics era has brought about new Omics biotechnologies, such as proteomics and metabolomics, as well as their novel applications to personal genomics and the quantified self. These advances are now also catalyzing other and newer post-genomics innovations, leading to convergences between Omics and nanotechnology. In this work, we systematically contextualize and exemplify an emerging strand of post-genomics life sciences, namely, nanoproteomics and its applications in health and integrative biological systems. Nanotechnology has been utilized as a complementary component to revolutionize proteomics through different kinds of nanotechnology applications, including nanoporous structures, functionalized nanoparticles, quantum dots, and polymeric nanostructures. Those applications, though still in their infancy, have led to several highly sensitive diagnostics and new methods of drug delivery and targeted therapy for clinical use. The present article differs from previous analyses of nanoproteomics in that it offers an in-depth and comparative evaluation of the attendant biotechnology portfolio and their applications as seen through the lens of post-genomics life sciences and biomedicine. These include: (1) immunosensors for inflammatory, pathogenic, and autoimmune markers for infectious and autoimmune diseases, (2) amplified immunoassays for detection of cancer biomarkers, and (3) methods for targeted therapy and automatically adjusted drug delivery such as in experimental stroke and brain injury studies. As nanoproteomics becomes available both to the clinician at the bedside and the citizens who are increasingly interested in access to novel post-genomics diagnostics through initiatives such as the quantified self, we anticipate further breakthroughs in personalized and targeted medicine.

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The Role Radius of Curvature Plays in Thiolated Oligonucleotide Loading on Gold Nanoparticles

Cited by 452 publications

References 32 publications

Synthesis of oligo(lactose)-based thiols and their self-assembly onto gold surfaces

Synthesis of oligo(lactose)-based thiols and their self-assembly onto gold surfaces

The nature and implications of uniformity in the hierarchical organization of nanomaterials

Post-Genomics Nanotechnology Is Gaining Momentum: Nanoproteomics and Applications in Life Sciences

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