The Role, Significance, and Association of MicroRNA-10a/b in Physiology of Cancer

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that regulate the translation of mRNA and protein, mainly at the posttranscriptional level. Global expression profiling of miRNAs has demonstrated a broad spectrum of aberrations that correlated with several diseases, and miRNA-10a and miRNA-10b were the first examined miRNAs to be involved in abnormal activities upon dysregulation, including many types of cancers and progressive diseases. It is expected that the same miRNAs behave inconsistently within different types of cancer. This review aims to provide a set of information about our updated understanding of miRNA-10a and miRNA-10b and their clinical significance, molecular targets, current research gaps, and possible future applications of such potent regulators.

Ovarian Cancer and the Microbiome: Connecting the Dots for Early Diagnosis and Therapeutic Innovations—A Review

“…MicroRNAs (miRNAs) are short endogenous noncoding RNAs (18–25 nt) that have recently gained attention for their association with various cancers, including ovarian cancer [ 55 , 56 , 57 , 58 ]. The cervicovaginal microbiome may influence miRNA expression, potentially contributing to the OC development of ovarian cancer ( Figure 2 b).…”