The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis

Zhou, Rui; Wu, Jingrouzi; Liu, Bang; Jiang, Yiqun; Chen, Wei; Li, Jian; He, Quanyuan; He, Zuping

doi:10.1007/s00018-019-03101-9

Cited by 188 publications

(96 citation statements)

References 126 publications

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“…Leydig cells are a flock of cells present in the interstitial region between seminiferous tubules. They are the primary source of androgens, which can bind the androgen receptors (AR) on peritubular myoid cells and SCs, thereby participating in spermatogenesis [93]. Leydig cells can bind and retain both normal and malignant T lymphoblasts on their surface, and the coculture of Leydig cells and T cells show the suppressive effect of Leydig cells on the proliferation of the latter [94].…”

Section: T Lymphocytes and Leydig Cellsmentioning

confidence: 99%

T Lymphocytes and Testicular Immunity: A New Insight into Immune Regulation in Testes

Gong

Zeng

et al. 2020

IJMS

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The immune privilege of the testes is necessary to prevent immune attacks to gamete-specific antigens and paternal major histocompatibility complex (MHC) antigens, allowing for normal spermatogenesis. However, infection and inflammation of the male genital tract can break the immune tolerance and represent a significant cause of male infertility. Different T cell subsets have been identified in mammalian testes, which may be involved in the maintenance of immune tolerance and pathogenic immune responses in testicular infection and inflammation. We reviewed the evidence in the published literature on different T subtypes (regulatory T cells, helper T cells, cytotoxic T cells, γδ T cells, and natural killer T cells) in human and animal testes that support their regulatory roles in infertility and the orchitis pathology. While many in vitro studies have indicated the regulation potential of functional T cell subsets and their possible interaction with Sertoli cells, Leydig cells, and spermatogenesis, both under physiological and pathological processes, there have been no in situ studies to date. Nevertheless, the normal distribution and function of T cell subsets are essential for the immune privilege of the testes and intact spermatogenesis, and T cell-mediated immune response drives testicular inflammation. The distinct function of different T cell subsets in testicular homeostasis and the orchitis pathology suggests a considerable potential of targeting specific T cell subsets for therapies targeting chronic orchitis and immune infertility.

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Section: T Lymphocytes and Leydig Cellsmentioning

confidence: 99%

T Lymphocytes and Testicular Immunity: A New Insight into Immune Regulation in Testes

Gong

Zeng

et al. 2020

IJMS

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“…Seminiferous tubules are the place where spermatozoa are produced, which are composed of Sertoli cells, spermatogonia, spermatocytes and spermatids. And interstitial tissue mainly includes blood vessels, lymphatic vessels, fibroblasts, macrophages, columnar cells and Leydig cells [26]. A histological analysis of testicular tissue from control group revealed a normal process of spermatogenesis, with a regular arrangement of spermatogenic epithelial cells in the seminiferous tubules.…”

Section: Qlps Treatment Reverses Histopathological Damagementioning

confidence: 98%

Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia

Zhang

et al. 2020

BMC Complement Med Ther

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AbstractsBackground: Qilin pills (QLPs), a classic Traditional Chinese Medicine (TCM) formula for treating male infertility, effectively improve semen quality in clinical trials. This study was designed to evaluate the effects of QLPs on spermatogenesis, reproductive hormones, oxidative stress, and the testis-specific serinekinase-2 (TSSK2) gene in a rat model of oligoasthenospermia. Methods: Forty adult male Sprague-Dawley (SD) rats were randomly divided into four groups. The rat model with oligoasthenospermia was generated by intragastric administration of tripterygium glycosides (TGs) once daily for 4 weeks. Then, two treatment groups were given different doses (1.62 g/kg and 3.24 g/kg) of QLPs once daily for 60 days. Sperm parameters, testicular histology and reproductive hormone measurements, oxidative stress tests, and TSSK2 expression tests were carried out.Results: QLPs effectively improved semen parameters and testicular histology; restored the levels of FSH, LH, PRL, fT, and SHBG; reduced the levels of oxidative stress products (ROS and MDA); increased testicular SOD activity; and restored the expression of spermatogenesis-related gene TSSK2. Conclusion:QLPs have a therapeutic effect on a rat model of oligoasthenospermia, and this effect is manifested as improvement of semen quality and testis histology, gonadal axis stability, decreased oxidative stress, and the regulation of testis-specific spermatogenesis-related gene TSSK2.

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“…Given that spermatogenesis in the testes is induced by testosterone (Banihani, ; Smith & Walker, ; Zhou et al, ), then the observed negative effects of aspirin on semen quality parameters may be attributable, albeit partially, to the disruption of testosterone production.…”

Section: Mechanistic Studiesmentioning

confidence: 99%

Effect of aspirin on semen quality: A review

Banihani

2019

Andrologia

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According to the PubMed data base, there are at least fifty published articles that link between aspirin and semen quality. However, such link has yet to be comprehensively discussed and summarised. This work reviews and summarises the effect of aspirin on semen quality and sperm fertility characteristics, and hence on semen fertilising ability. To achieve this contribution, an electronic search of PubMed and Scopus databases was conducted for original manuscripts, presented from January 1974 through September 2019, via the keywords “aspirin” and “acetylsalicylic acid” versus “sperm” and “semen.” In summary, there is a scientific research consensus that reveals negative effects of aspirin on semen quality. Still, clinical studies that directly examine the effect of aspirin on the main semen quality parameters are needed to support this conclusion. Mechanistically, the negative documented effect of aspirin on semen quality parameters may be attributable to decreased synthesis of testosterone, reduced function of nuclear factor kappa‐light‐chain‐enhancer of activated B cells, decreased formation of testicular prostaglandins, reduced production of seminal nitric oxide and increased oxidative injury to sperm.

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The roles and mechanisms of Leydig cells and myoid cells in regulating spermatogenesis

Cited by 188 publications

References 126 publications

T Lymphocytes and Testicular Immunity: A New Insight into Immune Regulation in Testes

T Lymphocytes and Testicular Immunity: A New Insight into Immune Regulation in Testes

Effects of Qilin pills on spermatogenesis, reproductive hormones, oxidative stress, and the TSSK2 gene in a rat model of oligoasthenospermia

Effect of aspirin on semen quality: A review

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