The roles of aerobic exercise training and suppression IL-6 gene expression by RNA interference in the development of insulin resistance

Tang, Hui; Xie, Minhao; Lei, Yu; Zhou, Liang; Xu, Yuping; Cai, Jianguang

doi:10.1016/j.cyto.2012.11.027

Cited by 9 publications

(7 citation statements)

References 67 publications

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“…IL-6 menyebabkan lipolisis pada otot rangka dan jaringan lemak subkutan abdomen melalui aktivasi AMPK. [6][7][8][9] Tujuan penelitian ini adalah mengetahui perbedaan efek interval training tipe cepat, interval training tipe lambat, dan continuous training intensitas sedang terhadap respons fisiologis berat badan dan nilai indeks Lee, serta respons molekuler adiponektin, IL-6, glukosa, dan trigliserida plasma pada tikus Wistar model obesitas. Setelah digunakan analisis statistik uji ANOVA terlihat perbedaan bermakna (p=0,000) pada variabel berat badan, nilai indeks Lee, kadar adiponektin, IL-6, glukosa dan juga trigliserida; mengetahui efek perlakuan yang paling besar terhadap variabel berat badan, nilai indeks Lee, kadar adiponektin, IL-6, glukosa, dan trigliserida dilakukan Uji Bonferroni.…”

Section: 2unclassified

“…7 yang menyatakan bahwa ditemukan peningkatan ekspresi mRNA AdipoR1 dan adipoR2 pada otot rangka mencit model obesitas yang diberikan interval berenang 3-5 kali perminggu, dibanding dengan kontrol.Penelitian Tang, dkk. 9 di China pada tikus obesitas, juga menyatakan bahwa ditemukan peningkatan kadar adiponektin pada kelompok perlakuan lari di atas treadmill tikus dibanding dengan kontrol Boutcher 2 di Australia juga melaporkan, bahwa sesudah pemberian perlakuan high-intensity intermittent exercise…”

Section: Pembahasanunclassified

“…IL-6 berperan mengarahkan substrat ekstraseluler selama aktivitas fisik, yaitu mengatur produksi glukosa endogen seperti cara kerja hormonal. [13][14][15] Pemahaman suatu mekanisme perubahan molekular dari adiponektin dan IL-6 dipengaruhi oleh aktivitas fisik sebelumnya, yaitu interval training tipe lambat lebih besar meningkatkan kadar IL-6 plasma dan lebih besar menurunkan kadar adiponektin plasma, diduga akan lebih besar menstimulasi lipolisis. Hal ini terbukti dari Interval training tipe lambat lebih besar dalam menurunkan nilai indeks Lee.…”

Section: Gambar 3 Uji Bonferroni Perbedaan Rata-rata Kadar Il-6 Dan Gunclassified

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Efek Interval Training terhadap Indeks Lee, Kadar Adiponektin, dan IL-6 pada Tikus Model Obesitas

Zein¹,

Lubis²,

Purba³

2017

mkb

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AbstrakKenaikan berat badan pada tikus model obesitas yang tetap diberikan pakan tinggi lemak terus berlangsung, akan tetapi jenis aktivitas fisik yang tepat mungkin dapat memperlambatnya. Penelitian ini bertujuan mengetahui perbedaan efek interval training tipe cepat, interval training tipe lambat, dan continuous training intensitas sedang terhadap berat badan, nilai indeks Lee, serta kadar adiponektin dan IL-6. Penelitian ini dilakukan di Laboratorium Farmakologi dan Terapi Fakutas Kedokteran Unpad pada bulan April-Mei 2014. Penelitian ini menggunakan posttest-only control group design pada 28 ekor tikus model obesitas (indek Lee >0,30), kadar adiponektin dan IL-6 plasma diperiksa dengan metode ELISA. Hasil penelitian menunjukkan perlakuan interval training tipe lambat lebih baik dibanding dengan interval training tipe cepat, continuous training intensitas sedang dan kontrol, yaitu kenaikan berat badan (2,34% vs 10,79% vs 4,49% vs 7,58%, p=0,000), penurunan kadar adiponektin (9,04 vs 10,27 vs 10,57 vs 7,24 ng/mL, p=0,000), glukosa (101,91±7,1 vs 113,63±6,4 vs 144,03±9,0 vs 82,24±5,9 mg/dL, p=0,000), trigliserida (28,07±3,3 vs 34,14±5,7 vs 42,00±4,9 vs 17,34±2,7 mg/dL, p=0,000), peningkatan kadar IL-6 (60,29±3,1 vs 54,55±2,1 vs 50,76±4,1 vs 56,36±2,9 pg/mL, p=0,000), dan penurunan nilai indeks Lee (7,3% vs 3,6% vs 6,4% vs 5,2%, p=0,000). Weight gain increase in obese rats that are continuously fed with fat rich chow may be slowed downs by putting them on a training regimen. This study aimed to determine the differences between the effects of fast-type interval training, slow-type interval training, and moderate-intensity continuous training on weight gain, Lee index, adiponectine, and IL-6. Using a post-test only control group, this study involved 28 obese rats (Lee index values >0.30). Adiponectin and IL-6 levels were tested using ELISA. This research was conducted in Pharmacology and

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Section: 2unclassified

Section: Pembahasanunclassified

Section: Gambar 3 Uji Bonferroni Perbedaan Rata-rata Kadar Il-6 Dan Gunclassified

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Efek Interval Training terhadap Indeks Lee, Kadar Adiponektin, dan IL-6 pada Tikus Model Obesitas

Zein¹,

Lubis²,

Purba³

2017

mkb

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“…Many studies indicate the molecular mechanisms developing insulin resistance are based on various specific molecules such as cytokines [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. This information [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , ...…”

Section: Introductionmentioning

confidence: 99%

The Proposal of Molecular Mechanisms of Weak Organic Acids Intake-Induced Improvement of Insulin Resistance in Diabetes Mellitus via Elevation of Interstitial Fluid pH

Marunaka

2018

IJMS

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Blood contains powerful pH-buffering molecules such as hemoglobin (Hb) and albumin, while interstitial fluids have little pH-buffering molecules. Thus, even under metabolic disorder conditions except severe cases, arterial blood pH is kept constant within the normal range (7.35~7.45), but the interstitial fluid pH under metabolic disorder conditions becomes lower than the normal level. Insulin resistance is one of the most important key factors in pathogenesis of diabetes mellitus, nevertheless the molecular mechanism of insulin resistance occurrence is still unclear. Our studies indicate that lowered interstitial fluid pH occurs in diabetes mellitus, causing insulin resistance via reduction of the binding affinity of insulin to its receptor. Therefore, the key point for improvement of insulin resistance occurring in diabetes mellitus is development of methods or techniques elevating the lowered interstitial fluid pH. Intake of weak organic acids is found to improve the insulin resistance by elevating the lowered interstitial fluid pH in diabetes mellitus. One of the molecular mechanisms of the pH elevation is that: (1) the carboxyl group (R-COO−) but not H+ composing weak organic acids in foods is absorbed into the body, and (2) the absorbed the carboxyl group (R-COO−) behaves as a pH buffer material, elevating the interstitial fluid pH. On the other hand, high salt intake has been suggested to cause diabetes mellitus; however, the molecular mechanism is unclear. A possible mechanism of high salt intake-caused diabetes mellitus is proposed from a viewpoint of regulation of the interstitial fluid pH: high salt intake lowers the interstitial fluid pH via high production of H+ associated with ATP synthesis required for the Na+,K+-ATPase to extrude the high leveled intracellular Na+ caused by high salt intake. This review article introduces the molecular mechanism causing the lowered interstitial fluid pH and insulin resistance in diabetes mellitus, the improvement of insulin resistance via intake of weak organic acid-containing foods, and a proposal mechanism of high salt intake-caused diabetes mellitus.

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“…Also, the improved effects on fatty acid metabolism due to changed expression of a number of lipogenic and glycolytic enzymes in the liver caused by 5′-Adenosine monophosphate-activated protein kinase activation (23,24). Finally, the antiinflammatory effects of aerobic exercise reduces the level of serum IL-6 which may inhibit insulin resistance (25).…”

Section: Discussionmentioning

confidence: 99%

Aerobic exercise training modulates biochemical parameters in type 2 diabetic patients with chronic hepatitis C

2017

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The roles of aerobic exercise training and suppression IL-6 gene expression by RNA interference in the development of insulin resistance

Cited by 9 publications

References 67 publications

Efek Interval Training terhadap Indeks Lee, Kadar Adiponektin, dan IL-6 pada Tikus Model Obesitas

Efek Interval Training terhadap Indeks Lee, Kadar Adiponektin, dan IL-6 pada Tikus Model Obesitas

The Proposal of Molecular Mechanisms of Weak Organic Acids Intake-Induced Improvement of Insulin Resistance in Diabetes Mellitus via Elevation of Interstitial Fluid pH

Aerobic exercise training modulates biochemical parameters in type 2 diabetic patients with chronic hepatitis C

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