The roles of apoptosis and mitosis in atrophy of the rat sublingual gland

Biological behavior of myoepithelial cells in the regeneration of rat atrophied sublingual glands following release from duct ligation

“…According to previous reports, duct cells increase and acinar cells disappear in atrophic salivary glands (Walker & Gobé 1987, Cummins et al 1994, Burgess & Dardick 1998, Scott et al 1999, Takahashi et al 2000, 2002. In the regeneration, acinar cells differentiate from duct cells remaining in the atrophied glandular tissue and then actively proliferate , Cummins et al 1994, Takahashi et al 2004a, 2005.…”

“…Although these phenomena have all been observed in the three major salivary glands, there are a number of differences among the three glands. For instance, most acinar cells disappear by apoptotic cell death in the atrophy of parotid glands (Walker & Gobé 1987, Scott et al 1999, Ihrler et al 2004) and submandibular glands (Takahashi et al 2000) but by de-differentiation from acinar to duct cells and necrosis in addition to apoptosis in sublingual gland atrophy (Takahashi et al 2002). In the regenerative process of parotid (Scott et al 1999) and submandibular glands (Takahashi et al 2004a), apoptosis occurs rarely, like in the normally functioning glands, however apoptosis actively participates in sublingual gland regeneration, remodeling the regenerated glandular tissue (Takahashi et al 2005).…”

Inhibition of Src and p38 MAP kinases suppresses the change of claudin expression induced on dedifferentiation of primary cultured parotid acinar cells

“…To investigate the mechanism of atrophy and regeneration of acinar cells, studies of duct ligation and deligation have been performed (7,39,44,49,53). Ligation of excretory ducts leads to acinar atrophy and numerous duct-like structures, which are considered to be derived from surviving atrophic acini (7,49).…”

Stereology and ultrastructure of the salivary glands of diabetic Nod mice submitted to long‐term insulin treatment

“…This type of diabetes results from absolute insulin deficiency caused by the autoimmune destruction of ␤-cells (Hamilton and Blackwood, 1977). The relationship between diabetes mellitus and both cellular alterations and changes in salivary components has been studied in experimental and clinical investigations (Chavez et al, 2000;Watanabe et al, 2001;Takahashi et al, 2002). Generally, a decrease in salivary flow and in salivary components is observed in experimental animals and diabetic patients (Anderson and Shapiro, 1980;Chavez et al, 2000).…”