The roles of calcium-sensing receptor (CaSR) in heavy metals-induced nephrotoxicity

Kosiba, Anthony Adebayiga; Wang, Yanwei; Chen, Dongfeng; Wong, Chris K C; Gu, Jie; Shi, Haifeng

doi:10.1016/j.lfs.2019.117183

Cited by 19 publications

(8 citation statements)

References 153 publications

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“…Recent investigations on mouse renal tubular epithelial cells have shown that cadmium can induce Ca(II) release from endoplasmic reticulum (ER) stores through the phospholipase C (PLC)-IP 3 pathway, leading to ROS generation [ 104 ]. It has been deciphered that cadmium ions cause kidney damage by increasing intracellular Ca(II) levels, mitogen activated protein kinase (MAPK) activation, and by altering the activities of ion transporters in renal cells [ 105 ]. The elevation of intracellular Ca(II) associated with ROS generation is also responsible for Cd-induced apoptosis and cytotoxicity in immune cells [ 106 ].…”

Section: The Impact Of Toxic Metals On Human Enzymatic Pathwaysmentioning

confidence: 99%

“…The elevation of intracellular Ca(II) associated with ROS generation is also responsible for Cd-induced apoptosis and cytotoxicity in immune cells [ 106 ]. It has been suggested that activation of CaSR by calcimimetics can prevent Cd-induced apoptosis by restoring proper Ca(II) levels, switching the MAPK pathways and reducing ROS generation [ 105 ]. On the other hand, cadmium ions can deplete calcium stores over longer periods of time [ 103 ].…”

Section: The Impact Of Toxic Metals On Human Enzymatic Pathwaysmentioning

confidence: 99%

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Heavy Metals and Human Health: Possible Exposure Pathways and the Competition for Protein Binding Sites

2021

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Heavy metals enter the human body through the gastrointestinal tract, skin, or via inhalation. Toxic metals have proven to be a major threat to human health, mostly because of their ability to cause membrane and DNA damage, and to perturb protein function and enzyme activity. These metals disturb native proteins’ functions by binding to free thiols or other functional groups, catalyzing the oxidation of amino acid side chains, perturbing protein folding, and/or displacing essential metal ions in enzymes. The review shows the physiological and biochemical effects of selected toxic metals interactions with proteins and enzymes. As environmental contamination by heavy metals is one of the most significant global problems, some detoxification strategies are also mentioned.

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Section: The Impact Of Toxic Metals On Human Enzymatic Pathwaysmentioning

confidence: 99%

Section: The Impact Of Toxic Metals On Human Enzymatic Pathwaysmentioning

confidence: 99%

Heavy Metals and Human Health: Possible Exposure Pathways and the Competition for Protein Binding Sites

2021

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“…The pathology ndings, including crystals seen in the tubules, suggest this possibility. However, the absence of symptoms commonly observed in heavy metal poisoning cases, such as encephalopathy, seizures, mental status changes, papilledema, ataxia, and abdominal pain, makes this diagnosis challenging [12], [13].…”

Section: Discussionmentioning

confidence: 99%

A Case of Acute Tubulointerstitial Nephritis Following the Use of Chenopodium album L

Demiray¹,

yılmaz,

Demiray

et al. 2024

Preprint

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Introduction: Chenopodium album, commonly known as "lambsquarters," is a plant consumed as food and used in traditional medicine. Its popularity is increasing due to the belief that it has fewer side effects compared to synthetic drugs. However, its use can lead to acute or chronic poisoning. The growing interest in herbal remedies, along with uncontrolled usage and disregard for expert recommendations, contributes to adverse effects. Case Presentation : A 68-year-old female patient presented to the emergency department with nausea, vomiting, and flank pain following the use of lambsquarters. Impaired kidney function was detected in the patient. A biopsy performed after Chenopodium album usage led to the diagnosis of tubulointerstitial nephritis (TIN). The patient responded positively to corticosteroid and hemodialysis treatment. Discussion Caution is necessary in the use of herbal medicines and traditional treatments. A thorough evaluation of factors such as patients' nutritional status, herbal product usage, medication history, and genetic background is crucial. Chenopodium album can cause tubulointerstitial nephritis, resulting in kidney damage. Similarly, heavy metal poisoning through herbal products can lead to kidney damage. Adopting a multidisciplinary approach in the diagnosis and treatment process can contribute to better patient management. Conclusion This case presents a rare instance of tubulointerstitial nephritis developed due to the use of herbal products. Physicians should inquire about patients' history of exogenous substance use and conduct a comprehensive assessment, keeping such situations in mind. Conscious use of herbal medicines and traditional treatments can help prevent serious complications like kidney damage.

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“…The relation of cell death and autophagy is complex and occasionally contradictory, but it is critical to cell fate. Intriguingly, Ca 2+ signaling acts as a bridge linking these two types of cellular activities [72][73][74][75][76]. Ca 2+ promote cell proliferation and survival through release of IP3R by the ER; Ca 2+ is subsequently transferred to mitochondria to activate mitochondrial metabolism.…”

Section: Ca 2+ Signaling Links Cell Death and Autophagy In Kidney Cellsmentioning

confidence: 99%

Calcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease

Niu

Guo

Kong

et al. 2021

Cells

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The kidney is an important organ for the maintenance of Ca2+ homeostasis in the body. However, disruption of Ca2+ homeostasis will cause a series of kidney diseases, such as acute kidney injury (AKI), chronic kidney disease (CKD), renal ischemia/reperfusion (I/R) injury, autosomal dominant polycystic kidney disease (ADPKD), podocytopathy, and diabetic nephropathy. During the progression of kidney disease, Ca2+ signaling plays key roles in various cell activities such as necrosis, apoptosis, eryptosis and autophagy. Importantly, there are complex Ca2+ flux networks between the endoplasmic reticulum (ER), mitochondria and lysosomes which regulate intracellular Ca2+ signaling in renal cells and contribute to kidney disease. In addition, Ca2+ signaling also links the crosstalk between various cell deaths and autophagy under the stress of heavy metals or high glucose. In this regard, we present a review of Ca2+ signaling in cell death and crosstalk with autophagy and its potential as a therapeutic target for the development of new and efficient drugs against kidney diseases.

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The roles of calcium-sensing receptor (CaSR) in heavy metals-induced nephrotoxicity

Cited by 19 publications

References 153 publications

Heavy Metals and Human Health: Possible Exposure Pathways and the Competition for Protein Binding Sites

Heavy Metals and Human Health: Possible Exposure Pathways and the Competition for Protein Binding Sites

A Case of Acute Tubulointerstitial Nephritis Following the Use of Chenopodium album L

Calcium Signaling Mediates Cell Death and Crosstalk with Autophagy in Kidney Disease

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