The Roles of ESCRT Proteins in Healthy Cells and in Disease

Ilievska, Jasmina; Bishop, Naomi; Annesley, Sarah J.; Fisher, Paul R.

doi:10.5772/33537

Cited by 2 publications

(3 citation statements)

References 188 publications

(200 reference statements)

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“…The reason why model organisms are able to contribute so effectively to our understanding of human diseases lies in the high degree of molecular conservation found between metazoan species, and in the conserved nature of protein-protein, and other, networks (Gandhi et al, 2006). Indeed, even bacteria, plants, protists, and fungi are being exploited to explore differing aspects of biology relevant to human disease (Annesley & Fisher, 2009;Ilievska et al, 2011;McGary et al, 2010;Spradling et al, 2006). …”

Section: Role Of Animal Modelsmentioning

confidence: 99%

“…4). For example, genes encoding the ESCRT (endosomal sorting complex required for transport) proteins, are essential for the downregulation of many cell-surface signalling molecules (reviewed by Ilievska et al, 2011). Not only do many of the genes encoding ESCRT subunits appear to have caretaker functions, with mutations being linked to both cancer and neurological disorders, these genes also have an origin pre-dating the metazoan lineage (reviewed by Ilievska et al, 2011).…”

Section: Evolution Of Cancer Genesmentioning

confidence: 99%

“…For example, genes encoding the ESCRT (endosomal sorting complex required for transport) proteins, are essential for the downregulation of many cell-surface signalling molecules (reviewed by Ilievska et al, 2011). Not only do many of the genes encoding ESCRT subunits appear to have caretaker functions, with mutations being linked to both cancer and neurological disorders, these genes also have an origin pre-dating the metazoan lineage (reviewed by Ilievska et al, 2011). Model organisms, such as the amoeba, Dictyostelium discoideum (Annesley & Fisher, 2009;Williams RS et al, 2006), can therefore be used to study the fundamental molecular roles of these proteins (Blanc et al, 2009;Mattei et al, 2006).…”

Section: Evolution Of Cancer Genesmentioning

confidence: 99%

See 2 more Smart Citations

An Evolutionary Biology Approach to Understanding Neurological Disorders

Aziz¹,

Ilievska²,

Fisher³

et al. 2012

Protein Structure

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Section: Role Of Animal Modelsmentioning

confidence: 99%

Section: Evolution Of Cancer Genesmentioning

confidence: 99%

Section: Evolution Of Cancer Genesmentioning

confidence: 99%

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An Evolutionary Biology Approach to Understanding Neurological Disorders

Aziz¹,

Ilievska²,

Fisher³

et al. 2012

Protein Structure

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YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells

et al. 2021

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Background Glioma is a common type of malignant brain tumor with a high mortality and relapse rate. The endosomal sorting complex required for transport (ESCRT) has been reported to be involved in tumorigenesis. However, the molecular mechanisms have not been clarified. Methods Bioinformatics was used to screen the ESCRT subunits highly expressed in glioma tissues from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) databases. The function of the ESCRT subunits in glioma cells was examined in vitro. Transcriptome sequencing analyzed the target genes and signaling pathways affected by the ESCRT subunit. Finally, the relationship between m6A (N6-methyladenosine) modification and high expression of the ESCRT subunit was studied. Results VPS25 was upregulated in glioma tissues, which was correlated with poor prognosis in glioma patients. Furthermore, VPS25 knockdown inhibited the proliferation, blocked the cell cycle, and promoted apoptosis in glioma cells. Meanwhile, VPS25 induced a G0/G1 phase arrest of the cell cycle in glioma cells by directly mediating p21, CDK2, and cyclin E expression, and JAK-signal transducer and activator of transcription (STAT) activation. Finally, YTHDC1 inhibited glioma proliferation by reducing the expression of VPS25. Conclusion These results suggest that VPS25 is a promising prognostic indicator and a potential therapeutic target for glioma.

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The Roles of ESCRT Proteins in Healthy Cells and in Disease

Cited by 2 publications

References 188 publications

An Evolutionary Biology Approach to Understanding Neurological Disorders

An Evolutionary Biology Approach to Understanding Neurological Disorders

YTHDC1-mediated VPS25 regulates cell cycle by targeting JAK-STAT signaling in human glioma cells

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