The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols

Man, Andy W C; Xia, Ning; Daiber, Andreas; Li, Huige

doi:10.1111/bph.14850

Cited by 38 publications

(28 citation statements)

References 153 publications

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“…Polyphenols are secondary metabolites of plants, which have been widely studied on their beneficial effects as antioxidants [ 171 , 172 ]. Polyphenols can affect cholesterol metabolism via bile acid biosynthesis [ 173 ].…”

Section: Targeting the Circadian Clock For The Treatment Of Atheromentioning

confidence: 99%

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Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis

Man

Xia

2021

IJMS

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Every organism has an intrinsic biological rhythm that orchestrates biological processes in adjusting to daily environmental changes. Circadian rhythms are maintained by networks of molecular clocks throughout the core and peripheral tissues, including immune cells, blood vessels, and perivascular adipose tissues. Recent findings have suggested strong correlations between the circadian clock and cardiovascular diseases. Desynchronization between the circadian rhythm and body metabolism contributes to the development of cardiovascular diseases including arteriosclerosis and thrombosis. Circadian rhythms are involved in controlling inflammatory processes and metabolisms, which can influence the pathology of arteriosclerosis and thrombosis. Circadian clock genes are critical in maintaining the robust relationship between diurnal variation and the cardiovascular system. The circadian machinery in the vascular system may be a novel therapeutic target for the prevention and treatment of cardiovascular diseases. The research on circadian rhythms in cardiovascular diseases is still progressing. In this review, we briefly summarize recent studies on circadian rhythms and cardiovascular homeostasis, focusing on the circadian control of inflammatory processes and metabolisms. Based on the recent findings, we discuss the potential target molecules for future therapeutic strategies against cardiovascular diseases by targeting the circadian clock.

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Section: Targeting the Circadian Clock For The Treatment Of Atheromentioning

confidence: 99%

“…Polyphenols interact with circadian clock by modulating the amplitude and period of the clock gene oscillations [ 174 , 175 , 176 ]. The use of polyphenols in entraining the circadian clock has been widely studied and reviewed [ 171 , 177 , 178 , 179 ].…”

Section: Targeting the Circadian Clock For The Treatment Of Atheromentioning

confidence: 99%

Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis

Man

Xia

2021

IJMS

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“…However, it is still not entirely clear how the circadian clock and gut microbiota, in particular bacterial metabolites such as TMAO, are associated with the progression of atherosclerosis. Clock (Circadian Locomotor Output Cycles Kaput) and Bmal1 [Brain and Muscle ARNT (aryl hydrocarbon receptor nuclear translocator) -Like 1], two major circadian clock genes, play important regulatory role in atherogenesis, expression of Bmal1 and Clock decreased in patients with atherosclerosis (Winter and Soehnlein, 2018;Man et al, 2020). TMAO induces increased expression of lncRNA-NEAT1, Clock and Bmal1 and inhibits the MAPK pathways (Wu et al, 2019a).…”

Section: Circadian Rhythms Of Microbiome and Atherogenesismentioning

confidence: 99%

A Novel Insight at Atherogenesis: The Role of Microbiome

Kirichenko

Markina

Sukhorukov

et al. 2020

Front. Cell Dev. Biol.

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There is an important task of current medicine to identify mechanisms and new markers of subclinical atherosclerosis in order to develop early targets for the diagnosis and treatment of this disease, since it causes such widespread diseases as myocardial infarction, stroke, sudden death, and other common reasons of disability and mortality in developed countries. In recent years, studies of the human microbiome in different fields of medicine have become increasingly popular; there is evidence from numerous studies of the significant contribution of microbiome in different steps of atherogenesis. This review attempted to determine the current status of the databases PubMed and Scopus (until May, 2020) to highlight current ideas on the potential role of microbiome and its metabolites in atherosclerosis development, its mechanisms of action in lipids metabolism, endothelial dysfunction, inflammatory pathways, and mitochondrial dysfunction. Results of clinical studies elucidating the relationship of microbiome with subclinical atherosclerosis and cardiovascular disease considered in this article demonstrate strong association of microbiome composition and its metabolites with atherosclerosis and cardiovascular disease. Data on microbiome impact in atherogenesis open a wide perspective to develop new diagnostic and therapeutic approaches, but further comprehensive studies are necessary.

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“…However, growing evidence supports the hypothesis that resveratrol is possibly acting through the gut microbiota remodelling [150]. Recently, polyphenol is proposed as potential prebiotics which can shape the gut microbiota composition [151,152]. Shaping the gut microbiota to favour specific species or lowering the Firmicutes to Bacteroidetes ratio can provide protective effects to the host cardiovascular system [106].…”

Section: The Interaction Between Resveratrol Gut Microbiota and Artementioning

confidence: 99%

Resveratrol and the Interaction between Gut Microbiota and Arterial Remodelling

Man

Xia

2020

Nutrients

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Arterial remodelling refers to the alteration in the structure of blood vessel that contributes to the progression of hypertension and other cardiovascular complications. Arterial remodelling is orchestrated by the crosstalk between the endothelium and vascular smooth muscle cells (VSMC). Vascular inflammation participates in arterial remodelling. Resveratrol is a natural polyphenol that possesses anti-oxidant and anti-inflammatory properties and has beneficial effects in both the endothelium and VSMC. Resveratrol has been studied for the protective effects in arterial remodelling and gut microbiota, respectively. Gut microbiota plays a critical role in the immune system and inflammatory processes. Gut microbiota may also regulate vascular remodelling in cardiovascular complications via affecting endothelium function and VSMC proliferation. Currently, there is new evidence showing that gut microbiota regulate the proliferation of VSMC and the formation of neointimal hyperplasia in response to injury. The change in population of the gut microbiota, as well as their metabolites (e.g., short-chain fatty acids) could critically contribute to VSMC proliferation, cell cycle progression, and migration. Recent studies have provided strong evidence that correlate the effects of resveratrol in arterial remodelling and gut microbiota. This review aims to summarize recent findings on the resveratrol effects on cardiovascular complications focusing on arterial remodelling and discuss the possible interactions of resveratrol and the gut microbiota that modulate arterial remodelling.

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The roles of gut microbiota and circadian rhythm in the cardiovascular protective effects of polyphenols

Cited by 38 publications

References 153 publications

Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis

Circadian Rhythm: Potential Therapeutic Target for Atherosclerosis and Thrombosis

A Novel Insight at Atherogenesis: The Role of Microbiome

Resveratrol and the Interaction between Gut Microbiota and Arterial Remodelling

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