2016
DOI: 10.1159/000438641
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The Roles of MicroRNA-141 in Human Cancers: From Diagnosis to Treatment

Abstract: Cancer remains one of the most threatening causes of human health impairment, and the mechanisms underlying tumorigenesis have not been completely characterized. MicroRNAs (miRNAs) are a group of endogenous, small (18∼25 nucleotides) non-coding RNAs which negatively regulate gene expressions by directly binding to the 3'-untranslated regions (3'-UTRs) of the target messenger RNAs (mRNAs). Increasing evidence has demonstrated abnormal miRNA profiles and confirmed their involvement in tumor initiation and progre… Show more

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Cited by 96 publications
(73 citation statements)
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“…MiRNAs regulate many cellular functions such as cell proliferation, differentiation, and migration, and are implicated in pathologic conditions including cancer [13, 14]. MicroRNA-145 (miR-145) is a tumor suppressor that inhibits tumor cell growth and metastasis in many cancers [15-18].…”
Section: Introductionmentioning
confidence: 99%
“…MiRNAs regulate many cellular functions such as cell proliferation, differentiation, and migration, and are implicated in pathologic conditions including cancer [13, 14]. MicroRNA-145 (miR-145) is a tumor suppressor that inhibits tumor cell growth and metastasis in many cancers [15-18].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, the expression of miR‐141 and miR‐210 was also reported to be regulated by HPV (Wang et al ., ). miR‐141 was found to be up‐regulated in cervical cancer compared to their normal counterparts in other studies (Gao et al ., ; Rao et al ., ). The up‐regulation of miR‐141 in cervical cancer was observed in association with the dysregulation of DROSHA, a critical enzyme in the miRNA biogenesis pathway, for which the expression is suggested to be modulated by HPV16 E6/E7 oncoproteins (Harden and Munger, ; Muralidhar et al ., ).…”
Section: Resultsmentioning
confidence: 99%
“…miR-141 is another member of the miR-200 family, also involved in EMT, invasion, migration and drug resistance (154). miR-141 overexpression contributes to acquired chemoresistance, for both in vitro and in vivo models.…”
Section: A Network Analysis: the Most Central Ncrnas In Chemoresistancementioning
confidence: 99%