The roles of N6-methyladenosine methylation in the regulation of bone development, bone remodeling and osteoporosis

Li, Yuan; Meng, Li; Zhao, Baobing

doi:10.1016/j.pharmthera.2022.108174

Cited by 28 publications

(27 citation statements)

References 98 publications

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“…RNA modifications have a key influence in the regulation of many fundamental biological processes associated with chronic lung disease ( Table 1 ). The methylation of m 6 A can affect the RNA stability, localization, turnover, and translation efficiency of genes, thereby regulating cellular processes such as cell self-renewal, differentiation, invasion, and apoptosis, and is even critical for skeletal development and homeostasis [ 93 , 94 ]. The METTL3-METTL14 complex increases the expression of the cyclin-dependent kinase p21 by regulating m 6 A.…”

Section: Rna Modifications In Lung Cancer and Other Chronic Lung Dise...mentioning

confidence: 99%

RNA Epigenetics in Chronic Lung Diseases

Wang

Guo²,

Yan³

2022

Genes

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Chronic lung diseases are highly prevalent worldwide and cause significant mortality. Lung cancer is the end stage of many chronic lung diseases. RNA epigenetics can dynamically modulate gene expression and decide cell fate. Recently, studies have confirmed that RNA epigenetics plays a crucial role in the developing of chronic lung diseases. Further exploration of the underlying mechanisms of RNA epigenetics in chronic lung diseases, including lung cancer, may lead to a better understanding of the diseases and promote the development of new biomarkers and therapeutic strategies. This article reviews basic information on RNA modifications, including N6 methylation of adenosine (m6A), N1 methylation of adenosine (m1A), N7-methylguanosine (m7G), 5-methylcytosine (m5C), 2′O-methylation (2′-O-Me or Nm), pseudouridine (5-ribosyl uracil or Ψ), and adenosine to inosine RNA editing (A-to-I editing). We then show how they relate to different types of lung disease. This paper hopes to summarize the mechanisms of RNA modification in chronic lung disease and finds a new way to develop early diagnosis and treatment of chronic lung disease.

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Section: Rna Modifications In Lung Cancer and Other Chronic Lung Dise...mentioning

confidence: 99%

RNA Epigenetics in Chronic Lung Diseases

Wang

Guo²,

Yan³

2022

Genes

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“…Noncoding RNAs are a group of RNAs with gene expression regulation functions and without gene coding functions [ 13 ]. Noncoding RNAs mainly contain long noncoding RNAs, such as circRNAs [ 14 ] and lncRNAs [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The Effects of circ_000558/miR-1225-5p/ARL4C on Regulating the Proliferation of Renal Cell Carcinoma Cells

Xia

Shan

et al. 2023

Journal of Oncology

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Renal cell carcinoma (RCC) is one of the top ten tumors over the world. RCC is not sensitive to radiotherapy and chemotherapy. Therefore, it is necessary to find new targets for the treatment. CircRNAs are a special type of noncoding RNAs, which play important roles in many types of cancer. In this study, we found circ_000558 was upregulated in RCC cells, and it elevated the proliferation ability of RCC cells. The relationship between miR-1225-5p and circ_000558 or ARL4C was predicted via circBank and circular RNA interactome and confirmed by dual-luciferase reporter assay. Then, the effects of circ_000558/miR-1225-5p/ARL4C on RCC cell proliferation and apoptosis were assessed by CCK-8 assay. The results revealed that the knockdown of ARL4C significantly reduced RCC cell proliferation and overexpression of circ_000558 could significantly induce RCC cell proliferation after miR-1225-5p treatment further promoted the inhibitory ability of ARL4C knockdown. Overall, our study suggested that circ_000558/miR-1225-5p/ARL4C network was related to the RCC cell proliferation. This finding could provide new targets for the treatment and prognosis of RCC.

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“…Osteoporosis (OP) is a type of systemic skeletal and age-related disease characterized by stumpy bone mass and the microarchitectural weakening, leading to elevated bone fragility and thus a subsequent increased risk of fractures (1)(2)(3). OP frequently occurs in postmenopausal women, affecting about 1 out of 3 women over 50 years old (4,5).…”

Section: Introductionmentioning

confidence: 99%

Relationship between indices of circulating blood cells and bone homeostasis in osteoporosis

Hao

Guan

et al. 2022

Front. Endocrinol.

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Bone development have been shown to play an important role in regulating hematopoiesis as one major component of bone marrow microenvironment. Recent studies support the notion that there is an intricate relationship between hematopoiesis and bone homeostasis, however, little is known about the alterations in the hematopoietic lineages in pathologic conditions. Using various osteoporotic mouse models, we show here that bone microarchitecture abnormalities alter parameters of peripheral blood cells. The level of white blood cells is dynamics and negatively correlated with bone mineral density during the progression of osteoporosis. Furthermore, our clinical data confirm that osteoporosis is associated with abnormal circulating blood cell counts. These results demonstrated a causal link that osteoporosis is accompanied by the altered circulating blood cells, supporting the idea of a close interplay between hematopoiesis and bone homeostasis. Our study would propose that routine complete blood count might be applied as a potential diagnostic and putative marker for osteoporosis.

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The roles of N6-methyladenosine methylation in the regulation of bone development, bone remodeling and osteoporosis

Cited by 28 publications

References 98 publications

RNA Epigenetics in Chronic Lung Diseases

RNA Epigenetics in Chronic Lung Diseases

The Effects of circ_000558/miR-1225-5p/ARL4C on Regulating the Proliferation of Renal Cell Carcinoma Cells

Relationship between indices of circulating blood cells and bone homeostasis in osteoporosis

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