The roles of <scp>TNFAIP</scp>2 in cancers and infectious diseases

Jia, Lin; Shi, Yundong; Wen, Yi; Li, Wei; Feng, Jing; Chen, Ceshi

doi:10.1111/jcmm.13822

Cited by 80 publications

(79 citation statements)

References 45 publications

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“…IGF2 is present in follicular fluid and has recently been shown to promote malignant transformation in immortalized TE cell lines (Hsu et al, 2019). TNFAIP2 is thought to be involved in inflammatory angiogenesis and has been reported to down regulate NF-κB (Jia et al, 2018;Thair et al, 2015). If we suppose TNFAIP2 has a role in controlling NF-κB signaling in the TE, we would expect to see NF-κB signaling activity to be reduced in the proximal TE.…”

Section: Discussionmentioning

confidence: 99%

WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations

Rose

Bidarimath

Webster

et al. 2020

Preprint

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A substantial fraction of ovarian/extra-uterine high-grade serous carcinomas (HGSCs) likely originate in the distal region of the Fallopian tube's epithelium (TE) before implanting/metastasizing to the ovary. Unfortunately, molecular and cellular mechanisms rendering preferential cancer susceptibility of the human distal TE remain insufficiently elucidated, largely due to limited primary human TE gene expression data. Here we report an in depth bioinformatic characterization of 34 primary TE cell mRNA-seq samples.These samples were prepared from the proximal and distal TE regions of 12 normal Fallopian tubes. TE cells were segregated based on their aldehyde dehydrogenase (ALDH) activity. As compared to the proximal TE, cells from the distal region form organoids with higher frequency and larger size during serial organoid formation assays. Consistent with enrichment for organoid-forming stem/progenitor cells, ALDH+ cells have greater WNT signaling activity. Comparative evaluation of proximal and distal TE cell population's shows heightened inflammatory signaling in distal differentiated (ALDH-) TE.Furthermore, comparisons of proximal and distal TE cell populations finds that the distal TE express gene sets characteristic of four HGSC molecular sub-types, and that distal ALDH+ cell populations exhibit greater enrichment than their ALDH-counterparts. Taken together, our study shows that increased organoid forming capacity, WNT and inflammatory signaling, and HGSC signatures underlie the differences between distal and proximal regions of the human TE. These findings provide the basis for further mechanistic studies of distal TE susceptibility to the malignant transformation.

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Section: Discussionmentioning

confidence: 99%

WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations

Rose

Bidarimath

Webster

et al. 2020

Preprint

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“…Expression of TNFAIP2 was found to be abnormal in various cancers, including breast cancer, esophageal squamous cell carcinoma, and glioma (20,22,23). In cervical cancer, the expression of TNFAIP2 was signi cantly increased in CC tissues compared with normal tissues based on the analysis of the TCGA (The Cancer Genome Atlas) database (8). In addition, the disruption of the TNFAIP2 gene through viral integration contributed to the rapid progression of cervical cancer (10).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to its angiogenic effects, the overexpression of PGF is correlated with tumor stage, cancer progression and metastasis (7). TNFAIP2 (TNF alpha induced protein 2) is a primary response gene of TNFα, and the expression of TNFAIP2 is regulated by multiple transcription factors and signaling pathways, including NF-κB, KLF5 and retinoic acid (8). TNFAIP2 is an important angiogenic factor, which was signi cantly associated with intratumoral microvessel density (9).…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms of PGF and TNFAIP2 Genes Related to Cervical Cancer Risk Among Uygur Females from China

Ainiwaer

Maisaidi

Liu

et al. 2020

Preprint

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Abstract Background: PGF and TNFAIP2 are important angiogenic factors, which were abnormal expression in cervical cancer (CC). However, no report was investigating the associations between the polymorphisms in the PGF and TNFAIP2 genes and CC risk. Methods: We conducted a case-control study of 342 CC patients and 498 cancer-free controls in Chinese Uygur female population. Three selected SNPs (PGF rs8019391, PGF rs2268615, and TNFAIP2 rs710100) were genotyped to investigate the possible association of the polymorphisms in PGF and TNFAIP2 with the risk of CC. The analysis adjusted by age was used to assess associations of these SNPs with CC risk. Results: PGF rs2268615 (OR = 1.39, 95% CI = 1.04-1.86, p = 0.024) and TNFAIP2 rs710100 (OR = 1.44, 95% CI =1.07-1.95, p = 0.018) polymorphisms were significantly associated with the increased risk of CC. Moreover, PGF rs8019391 T allele was highly represented in patients with III–IV tumor stage (OR = 2.17, p = 4.58´10-4). MDR analysis revealed a positive interaction between the SNPs. Conclusion: Our data suggested that PGF rs2268615, and TNFAIP2 rs710100 polymorphisms may be risk factors for susceptibility to CC, which contributed to the increased risk of CC, and this finding requires further validation by larger studies.Trail registration: Not applicable.

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“…Expression of TNFAIP2 was found to be abnormal in various cancers, including breast cancer, esophageal squamous cell carcinoma, and glioma (20,22,23). In cervical cancer, the expression of TNFAIP2 was significantly increased in CC tissues compared with normal tissues based on the analysis of the TCGA (The Cancer Genome Atlas) database (8). In addition, the disruption of the TNFAIP2 gene through viral integration contributed to the rapid progression of cervical cancer (10).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to its angiogenic effects, the overexpression of PGF is correlated with tumor stage, cancer progression and metastasis (7). TNFAIP2 (TNF alpha induced protein 2) is a primary response gene of TNFα, and the expression of TNFAIP2 is regulated by multiple transcription factors and signaling pathways, including NF-κB, KLF5 and retinoic acid (8). TNFAIP2 is an important angiogenic factor, which was significantly associated with intratumoral microvessel density (9).…”

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China

Han

Husaiyin

et al. 2020

Preprint

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Background PGF and TNFAIP2 are important angiogenic factors, which were abnormal expression in cervical cancer (CC). However, there is no report on investigating associations between the polymorphisms in the PGF and TNFAIP2 genes and CC risk. Methods We conducted a case-control study of 342 CC patients and 498 cancer-free controls matched by age and ethnicity in Chinese Uygur female population. Three selected SNPs ( PGF rs8019391, PGF rs2268615, and TNFAIP2 rs710100) were genotyped to investigate the possible association of the polymorphisms in PGF and TNFAIP2 with the risk of CC. The logistic regression analysis adjusted by age was used to assess associations of these SNPs with CC risk. Results GF rs2268615 (OR = 1.39, 95% CI = 1.04-1.86, p = 0.024) and TNFAIP2 rs710100 (OR = 1.44, 95% CI =1.07-1.95, p = 0.018) polymorphisms were significantly associated with the increased risk of CC. Moreover, PGF rs8019391 T allele was highly represented in patients with III–IV tumor stage (OR = 2.17, p = 4.58×10 -4 ). MDR analysis revealed a positive interaction between the SNPs. Conclusions Our data suggested that PGF rs2268615, and TNFAIP2 rs710100 polymorphisms may be risk factors for susceptibility to CC, which contributed to the increased risk of CC, and this finding requires further validation by larger studies.

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The roles of TNFAIP2 in cancers and infectious diseases

Cited by 80 publications

References 45 publications

WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations

WNT and inflammatory signaling distinguish human Fallopian tube epithelial cell populations

Genetic Polymorphisms of PGF and TNFAIP2 Genes Related to Cervical Cancer Risk Among Uygur Females from China

Genetic polymorphisms of PGF and TNFAIP2 genes related to cervical cancer risk among Uygur females from China

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