The roles of serotonin in cell adhesion and migration, and cytoskeletal remodeling

Jayakumar, Joe Anand Kumar John; Panicker, Mitradas M.

doi:10.1080/19336918.2021.1963574

Cited by 5 publications

(2 citation statements)

References 125 publications

(144 reference statements)

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“…It is worth mentioning that the differential proteins screened in the healthy group compared with the BD group were similarly enriched in the biological process of cell adhesion. At the same time, John Jayakumar JAK et al [71] found that serotonin plays an important role in mental illness and the positive and negative effects of neuropsychiatric drugs through cell-associated adhesion, including depression, bipolar disorder, and schizophrenia. A sample of the group of 11 bipolar patients was compared to a sample of the group of 13 depressed patients.…”

Section: Identification and Functional Analysis Of Urine Proteome In ...mentioning

confidence: 99%

Exploring differences between depression and bipolar disorder through the urinary proteome

Liu,

Li,

Dong

et al. 2024

Preprint

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How to differentiate the diagnosis of depression and bipolar disorder has always been an important problem that needs to be solved urgently in clinical practice. In this study, from the perspective of urine proteomics, urine samples of similar age were collected from two hospitals to investigate the candidate biomarkers for differentiating the diagnosis of depression and bipolar disorder using both group analysis and one-to-many analysis(1 patient : many control samples). The experimental results of the paired group analysis showed that 108 differential proteins were identified in the depressed group compared to the bipolar group under strict screening conditions with screening criteria of FC ≥ 2 or ≤ 0.5 and a two-tailed unpaired t-test of P < 0.01, with an average of 3.7 randomly generated differential proteins, and a confidence level of 96.6 % for the correlation between these proteins and the disease difference. In the one-to-many analysis, 24 differential proteins were co-identified by the samples of 13 depressed patients, 16 of which showed a completely consistent trend of expression changes in all depressed patients studied, and 6 of which were associated with immunoglobulins; 41 differential proteins were co-identified by the samples of 12 depressed patients out of 13, and 19 of which showed a completely consistent trend of expression change in the These results reflect the strong consistency of differential proteins between the two groups of patients. 12 or more samples from depressed patients were enriched for differential proteins related to multiple biological processes and signaling pathways associated with the immune system, which is consistent with previous studies: immune mechanisms may be one of the pathogenetic mechanisms of major depression and that drugs with major immune targets can improve depressive symptoms. In the future, it may be possible to observe the immune status of patients with depression to provide direction and basis for the precise treatment of depression. The results of this paper show that urine proteomics can differentiate between depression and bipolar disorder, suggest possible mechanisms and potential targets for the treatment of depression and bipolar disorder, and provide a tool for future differential diagnosis and precision treatment of the diseases.

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Section: Identification and Functional Analysis Of Urine Proteome In ...mentioning

confidence: 99%

Exploring differences between depression and bipolar disorder through the urinary proteome

Liu,

Li,

Dong

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…The 5‐HT plays many critical roles during development, including the regulation of various cellular processes, such as cell division, differentiation, migration, myelination, synaptogenesis, neurite sprouting and dendritic pruning (Daubert & Condron, 2010; Jayakumar & Panicker, 2021; Lesch & Waider, 2012; Rojas et al, 2014), leading to the shaping of neural circuits in the brain. Because SSRIs can cross the placental barrier, exposure during pregnancy can lead to alterations in the brain (Hendrick et al, 2003) and behavior (Olivier et al, 2013) of developing fetuses.…”

Section: Introductionmentioning

confidence: 99%

Effects of prenatal exposure to fluoxetine on circadian rhythmicity in the locomotor activity and neuropeptide Y and 5‐HT expression in male and female adult Wistar rats

Linhares

Meurer

Aquino

et al. 2022

Intl J of Devlp Neuroscience

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Serotonin (5-HT) reuptake inhibitors, such as fluoxetine, are the most prescribed antidepressant for maternal depression. In this sense, it exposes mothers and the brains of infants to increased modulatory and trophic effects of serotonergic neurotransmission. 5-HT promotes essential brain changes throughout its development, which include neuron migration, differentiation and organisation of neural circuitries related to emotional, cognitive and circadian behavior. Early exposure to the SSRIs induces long-term effects on behavioral and neural serotonergic signalisation. We have aimed to evaluate the circadian rhythm of locomotor activity and the neurochemical content, neuropeptide Y (NPY) and 5-HT in three brain areas: intergeniculate leaflet (IGL), suprachiasmatic nuclei (SCN) and raphe nuclei (RN), at two zeitgebers (ZT6 and ZT18), in male and female rat's offspring early exposed (developmental period GD13-GD21) to fluoxetine (20 mg/kg). First, we have conducted daily records of the locomotor activity rhythm using activity sensors coupled to individual cages over 4 weeks. We have lastly evaluated the immunoreactivity of NPY in both SCN and IGL, as well the 5-HT expression in the dorsal and medial RN. In summary, our results showed that (1) prenatal fluoxetine affects phase entrainment of the rest/activity rhythm at ZT6 and ZT18, more in male than female specimens, and (2) modulates the NPY and 5-HT expression. Here, we show male rats are more susceptible to phase entrainment and the NPY and 5-HT misexpression compared to female ones. The sex differences induced by early exposure to fluoxetine in both the circadian rhythm of locomotor activity and the neurochemical expression into SCN, IGL and midbrain

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Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway

Xu¹,

Zhang²,

Zhang³

et al. 2023

The International Journal of Biochemistry & Cell Biology

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The roles of serotonin in cell adhesion and migration, and cytoskeletal remodeling

Cited by 5 publications

References 125 publications

Exploring differences between depression and bipolar disorder through the urinary proteome

Exploring differences between depression and bipolar disorder through the urinary proteome

Effects of prenatal exposure to fluoxetine on circadian rhythmicity in the locomotor activity and neuropeptide Y and 5‐HT expression in male and female adult Wistar rats

Menstrual blood-derived endometrial stem cells inhibit neuroinflammation by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 pathway

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