The roles of serum myoglobin, total CPK, and CK-MB isoenzyme in the acute phase of myocardial infarction

Grenadier, Ehud; Keidar, Shlomo; Kahana, Luna; Alpan, Gad; Marmur, Alon; Palant, A

doi:10.1016/0002-8703(83)90357-5

Cited by 69 publications

(18 citation statements)

References 16 publications

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“…In serum, only cTnI showed statistically significant differences, the highest values being obtained in the group of myocardial infarctions. A possible explanation for the absence of any statistical significance for serum CK-MB and myoglobin levels between the different diagnostic groups might be that they are released from different sites [25][26][27][28][29]. In this study, we chose the pericardial fluid because of its characteristics, among which are its proximity to myocardial tissue, meaning that any alterations in the cardiac muscle will be reflected at an earlier stage in this fluid than in serum.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic efficacy of biochemical markers in diagnosis post-mortem of ischaemic heart disease

Pérez-Cárceles

Noguera

Jiménez

et al. 2004

Forensic Science International

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Section: Discussionmentioning

confidence: 99%

Diagnostic efficacy of biochemical markers in diagnosis post-mortem of ischaemic heart disease

Pérez-Cárceles

Noguera

Jiménez

et al. 2004

Forensic Science International

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“…Grenadier et al 19 and Groth et al 20 have reported that myoglobin can serve as an invaluable aid in the diagnosis of infarct extension. Another possible reason for the higher baseline value of myoglobin in nonresponders could be an increased time interval between onset of symptoms and thrombolytic treatment in these patients compared with the patients in the responder and probable responder groups.…”

Section: Discussionmentioning

confidence: 99%

Myoglobin—A marker of reperfusion and a prognostic indicator in patients with acute myocardial infarction

Iqbal

Kazmi

Mehboobali

et al. 2004

Clinical Cardiology

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SummaryBackground: Early noninvasive identification of patients with occluded infarct-related arteries after thrombolysis has important prognostic and therapeutic implications. Recent reports indicate that plasma kinetics of cardiac marker proteins could be very useful in diagnosis of myocardial reperfusion. Although angiographic assessment remains the ideal procedure for determining patency, it is expensive, invasive, not within the reach of most patients in developing countries, and the long-term follow-up data are still sparse.Hypothesis: The present study was undertaken to investigate whether plasma kinetics of myoglobin in conjunction with clinical markers and another biochemical marker, creatine kinase, could be used to predict myocardial reperfusion more accurately and to investigate the correlation between myoglobin release after thrombolysis and mortality in patients with acute myocardial infarction (AMI) over a follow-up period of 18 months.Methods: Eighty-three consecutive patients with AMI receiving streptokinase treatment were studied for plasma kinetics of myoglobin in conjunction with clinical markers and creatine kinase to predict reperfusion and were followed for a period of 18 months.Results: Increased baseline mean ± standard deviation levels of myoglobin were observed among "nonresponders" to

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“…The delayed release kinetics of myosin can explain this fact. Although myoglobin and CK-MB are sensitive markers of use in ruling out cardiac injury regardless of its origin (Luna et al 1982(Luna et al , 1983Cairns et al 1983;Grenadier et al 1983;Stone and Willerson 1983;Stewart et al 1984;Lee and Goldman 1986;Hoberg et al 1987;Lee et al 1987;Isakov et al 1988), myosin is an excellent marker of severe myocardial injury. Higher concentrations of myosin are often accompanied by observable morphological signs of heart damage, and are thus useful in diagnosing sudden death due to heart-related causes.…”

Section: Discussionmentioning

confidence: 99%

Usefulness of myosin in the postmortem diagnosis of myocardial damage

et al. 1995

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In some situations the postmortem diagnosis of myocardial infarction is made difficult by the brief course of the fatal episode or by interferences caused by autolysis. In such cases, biochemical indices may provide a useful adjunct to morphological studies. Myosin is the main component of the contractile apparatus of muscle cells, so its determination may well be useful to evaluate myocardial injury. The purpose of the present study was to establish the diagnostic efficacy of postmortem myosin heavy chain determinations using monoclonal antibodies and to compare this data with structural findings used to diagnose acute myocardial ischaemia. We studied 105 cadavers with a mean age of 61.63 +/- 2.21 years. Cases were allocated to 1 of 7 diagnostic groups depending on the probable intensity of myocardial damage and cause of death. The highest serum and pericardial fluid values of myosin heavy chains were seen in subjects who showed morphological evidence of myocardial ischaemia. Mean pericardial fluid/serum ratios differed significantly between subjects with and without observable signs of heart damage.

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The roles of serum myoglobin, total CPK, and CK-MB isoenzyme in the acute phase of myocardial infarction

Cited by 69 publications

References 16 publications

Diagnostic efficacy of biochemical markers in diagnosis post-mortem of ischaemic heart disease

Diagnostic efficacy of biochemical markers in diagnosis post-mortem of ischaemic heart disease

Myoglobin—A marker of reperfusion and a prognostic indicator in patients with acute myocardial infarction

Usefulness of myosin in the postmortem diagnosis of myocardial damage

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