The roles of sex hormones in the pathophysiology of age‐related sarcopenia and frailty

Hosoi, Tatsuya; Yakabe, Mitsutaka; Hashimoto, Seiji; Akishita, Masahiro; Ogawa, Sumito

doi:10.1002/rmb2.12569

Cited by 3 publications

(1 citation statement)

References 70 publications

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“…Moreover, post-menopausal women have an increased risk of musculoskeletal injury and muscle wasting [40]. On the other hand, one may consider that muscle in males is under continuous stimulation of androgens acting as anabolic steroids via the androgen receptor (AR) [41]; it is unclear whether this stimulation may make male skeletal muscle more sensitive than female skeletal muscle to deleterious activities of the mutated HSPB8. In response to these findings, interventions such as hormone replacement therapy have been employed to counteract the adverse effects of menopause, reduce muscle and bone loss while restoring muscle protein balance [42 43].…”

Section: Gender-associated Myopathymentioning

confidence: 99%

A novel c.515delCHSPB8-multisystem proteinopathy associated with inclusion body myopathy with cardiomyopathy

Tan,

Duong,

Milone

et al. 2024

Preprint

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Mutations in theHSPB8, or heat shock protein family B (small) member 8, is a member of the chaperone-assisted selective autophagy complex and has recently been associated with rimmed vacuolar myopathy. We report a family with aHSPB8rimmed vacuolar myopathy caused by a novel c.515delC variant with progressive muscle weakness, pathological findings of rimmed vacuoles of muscle biopsy, and one individual who died of cardiomyopathy. Whole exome sequencing analyses revealed a c.515delC, resulting in a translational frameshift expected to elongate the protein by an additional 49 amino acid tail. We reviewed the clinical characteristics of all reported patients (N= 26, 15 males and 11 females) in the literature, and performed a genotype/phenotype analysis. Males in the families appeared to present with an earlier age of onset, more severe muscle weakness compared to females, and a higher prevalence of other organ system complications including cardiomyopathy in two males. In conclusion, this family expands the phenotype/genotype correlations inHSPB8-associated myopathy with rimmed vacuoles and c.515 delC. We note that c.515 appears to be a hot spot, and the phenotype appears to be more severe in males in this disease, with an earlier onset of the myopathy.

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Section: Gender-associated Myopathymentioning

confidence: 99%

A novel c.515delCHSPB8-multisystem proteinopathy associated with inclusion body myopathy with cardiomyopathy

Tan,

Duong,

Milone

et al. 2024

Preprint

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Vitamin D and hip protectors in osteosarcopenia: a combined hip fracture preventing approach

Giustina,

Giustina

2024

Rev Endocr Metab Disord

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Osteosarcopenia is an emerging clinical condition highly prevalent in the older people. Affected subjects due to their intrinsic skeletal fragility and propensity to falls are at elevated risk of hip fractures which can increase morbidity and mortality. Strategies for attenuating the impact of predisposing factors on hip fractures are not yet well defined and should derive from multidisciplinary care and collaborations. Our aim was to narratively review available data on the preventive role of vitamin D and hip protectors on hip fractures in older patients with sarcopenia. Older subjects are at high risk of vitamin D deficiency and of falls due to several concomitant factors besides osteosarcopenia. Vitamin D protective actions against hip fractures may be mediated by both skeletal (increased mineralization) and extra-skeletal (reduced risk of falls) actions. Hip protectors may act downstream attenuating the effects of falls although their use is still not yet enough widespread due to the suboptimal compliance obtained by traditional hard devices. Concomitant use of vitamin D and hip protectors may represent an effective strategy in the prevention of hip fractures which need to be tested in ad hoc designed clinical trials.

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Association of dietary inflammatory index with sarcopenia in patients with Metabolic dysfunction-associated fatty liver disease: a cross-sectional study

Wang,

Shi,

et al. 2024

Front. Nutr.

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BackgroundSarcopenia is a common complication of fatty liver, and sarcopenia increases the risk of advanced liver fibrosis in patients with Metabolic dysfunction-associated fatty liver disease (MAFLD). Chronic inflammation is the crucial link between sarcopenia and fatty liver. An anti-inflammatory diet is expected to be an essential measure to prevent sarcopenia in patients with fatty liver, and the dietary inflammatory index (DII) is a crucial tool for assessing the inflammatory potential of diets. However, the relationship between DII and sarcopenia in patients with fatty liver is unclear.ObjectiveThis study investigated the correlation between the dietary inflammatory index (DII) and sarcopenia in patients with Metabolic dysfunction-associated fatty liver disease (MAFLD).MethodsData for this study were obtained from the National Health and Nutrition Examination Survey (NHANES) 2017–2018, with 917 patients with MAFLD participating in the study. Participants were divided into three groups based on DII tertiles: group T1 (n = 305), group T2 (n = 306), and group T3 (n = 306), and binary logistic regression was used to assess the relationship between DII and sarcopenia with stratified analyses based on the weights recommended by the NHANES and multivariate linear regression was used to evaluate the association of DII with total appendicular lean mass.ResultsAfter adjusting for all confounders, DII was significantly and positively associated with the risk of sarcopenia in women [OR: 1.61, 95% CI: (1.226, 2.06), p < 0.001]. The risk of sarcopenia was higher in the T3 group compared to the T1 group [OR: 4.04, 95% CI: (1.66, 9.84), p = 0.002]. DII was negatively associated with appendicular lean mass adjusted for body mass index in both men and women.ConclusionDII was significantly associated with the risk of sarcopenia in female patients with MAFLD, with higher DII scores related to a higher risk of sarcopenia. Higher DII scores related to a higher risk of sarcopenia in men with significant fibrosis.

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The roles of sex hormones in the pathophysiology of age‐related sarcopenia and frailty

Cited by 3 publications

References 70 publications

A novel c.515delCHSPB8-multisystem proteinopathy associated with inclusion body myopathy with cardiomyopathy

A novel c.515delCHSPB8-multisystem proteinopathy associated with inclusion body myopathy with cardiomyopathy

Vitamin D and hip protectors in osteosarcopenia: a combined hip fracture preventing approach

Association of dietary inflammatory index with sarcopenia in patients with Metabolic dysfunction-associated fatty liver disease: a cross-sectional study

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