The roles of the cell division cycle-associated gene family in hepatocellular carcinoma

Tao, Qiang; Chen, Siliang; Liu, Jia; Zhao, Peng; Jiang, Lingmin; Tu, Xinyue; Tang, Xiang; Liu, Zonghao; Yasheng, Abudoukeyimu; Tuerxun, Kahaer; Zheng, Yun

doi:10.21037/jgo-21-110

Cited by 5 publications

(2 citation statements)

References 54 publications

(61 reference statements)

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“…Especially, we show that the calpain-6/YAP axis controls the expression of CENPF, TOP2A and ECT2. These proteins are important modulators of the cell cycle and cancer cell proliferation [ 39 , 40 ]. They contribute to a prognosis signature in hepatocellular carcinoma and breast cancer [ 41 , 42 ] and are associated with the development of metastases in synovial sarcoma and cervical cancer [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

A calpain-6/YAP axis in sarcoma stem cells that drives the outgrowth of tumors and metastases

et al. 2022

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Sarcomas include cancer stem cells, but how these cells contribute to local and metastatic relapse is largely unknown. We previously showed the pro-tumor functions of calpain-6 in sarcoma stem cells. Here, we use an osteosarcoma cell model, osteosarcoma tissues and transcriptomic data from human tumors to study gene patterns associated with calpain-6 expression or suppression. Calpain-6 modulates the expression of Hippo pathway genes and stabilizes the hippo effector YAP. It also modulates the vesicular trafficking of β-catenin degradation complexes. Calpain-6 expression is associated with genes of the G2M phase of the cell cycle, supports G2M-related YAP activities and up-regulated genes controlling mitosis in sarcoma stem cells and tissues. In mouse models of bone sarcoma, most tumor cells expressed calpain-6 during the early steps of tumor out-growth. YAP inhibition prevented the neoformation of primary tumors and metastases but had no effect on already developed tumors. It could even accelerate lung metastasis associated with large bone tumors by affecting tumor-associated inflammation in the host tissues. Our results highlight a specific mechanism involving YAP transcriptional activity in cancer stem cells that is crucial during the early steps of tumor and metastasis outgrowth and that could be targeted to prevent sarcoma relapse.

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Section: Discussionmentioning

confidence: 99%

A calpain-6/YAP axis in sarcoma stem cells that drives the outgrowth of tumors and metastases

et al. 2022

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“…Walker et al ( 7 ) conducted a guilty-by-association co-expression analysis on 1,176 human cDNA libraries to discover unknown human cell cycle genes, and found 8 previously unrecognized cell cycle genes [cell division cycle-associated protein1-8 (CDCA1-8)], which are highly co-expressed with many other known cell cycle genes, such as cyclin dependent kinase 1 (CDC2), cell division cycle 7 (CDC7), cell division cycle 23 (CDC23), and cyclin. This finding suggests that CDCA4 is involved in the regulation of the cell cycle ( 8 , 9 ). Studies have also been conducted on CDCA4 in tumors.…”

Section: Introductionmentioning

confidence: 92%

LINC00638/hsa-miR-29b-3p axis-mediated high expression of CDCA4 correlates with tumor immune infiltration and hepatocellular carcinoma progression

Wang¹,

Liang²,

Li³

et al. 2023

Transl Cancer Res

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Background This study sought to explore the role of cell division cycle-associated protein 4 (CDCA4) in liver hepatocellular carcinoma (LIHC) patients. Methods The RNA-sequencing raw count data and the respective clinical information of 33 different LIHC cancer and normal tissues were collected from the Genotype Tissue Expression (GTEX) and The Cancer Genome Atlas (TCGA) databases. The expression of CDCA4 in LIHC was determined via the University of Alabama at Birmingham Cancer Data Analysis Portal (UALCAN) database. The PrognoScan database was used to examine the correlation between CDCA4 and overall survival (OS) in LIHC. The interaction between the potential upstream microRNAs and the long non-coding RNAs (lncRNAs) and CDCA4 was explored using the Encyclopedia of RNA Interactomes (ENCORI) database. Finally, the biological role of CDCA4 in LIHC was investigated by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG)analyses. Results CDCA4 RNA expression was elevated in the LIHC tumor tissues and linked to adverse clinical characteristics. It was also upregulated in most tumor tissues in the GTEX and TCGA data sets. According to the receiver operating characteristic (ROC) curve analysis, CDCA4 is a potential a biomarker for the diagnosis of LIHC. According to the Kaplan-Meier (KM) curve analysis, patients with LIHC in TCGA data set with low expression levels of CDCA4 had better than high expression levels in OS, disease-specific survival (DSS), and progression free interval (PFI). The gene set enrichment analysis (GSEA) suggested that CDCA4 mainly affected the biological events of LIHC by participating in the cell cycle, T cell receptor signaling pathway, DNA replication, glucose metabolism, and mitogen activated protein kinase (MAPK) signaling pathway. Based on the competing endogenous RNA concept and the correlation, expression, and survival analysis results, we believe that LINC00638/hsa miR-29b-3p/CDCA4 should be a potential regulatory pathway in LIHC. Conclusions The low expression of CDCA4 significantly improves the prognosis of LIHC patients, and CDCA4 is a potential new biomarker for LIHC prognosis prediction. CDCA4-mediated LIHC carcinogenesis may involve tumor immune evasion and anti-tumor immunity. LINC00638/hsa-miR-29b-3p/CDCA4 should be a potential regulatory pathway in LIHC, and these findings provide a new perspective for the development of anti-cancer strategies in LIHC.

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Integration analysis of cell division cycle-associated family genes revealed potential mechanisms of gliomagenesis and constructed an artificial intelligence-driven prognostic signature

Yu,

Tian,

Feng

et al. 2024

Cellular Signalling

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The roles of the cell division cycle-associated gene family in hepatocellular carcinoma

Cited by 5 publications

References 54 publications

A calpain-6/YAP axis in sarcoma stem cells that drives the outgrowth of tumors and metastases

A calpain-6/YAP axis in sarcoma stem cells that drives the outgrowth of tumors and metastases

LINC00638/hsa-miR-29b-3p axis-mediated high expression of CDCA4 correlates with tumor immune infiltration and hepatocellular carcinoma progression

Integration analysis of cell division cycle-associated family genes revealed potential mechanisms of gliomagenesis and constructed an artificial intelligence-driven prognostic signature

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