The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: A study of the combination effects of the 2-herb formula

Cheung, David Wing-Shing; Koon, Chi Man; Ng, CF; Leung, Ping‐Chung; Fung, Kwok‐Pui; Poon, Simon K.; Lau, Clara Bik‐San

doi:10.1016/j.jep.2012.08.011

Cited by 46 publications

(19 citation statements)

References 34 publications

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“…This method allows for more accurate valuation of the combination contribution made by each agent on a mathematical level line where all points are collected on a surface that lies at a specific value [288, 305, 310]. There are, however, other complex methods that can also be used [311, 312]. …”

Section: Essential Oil Combinationsmentioning

confidence: 99%

Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases

Orchard

Vuuren

2017

Evidence-Based Complementary and Alternative Medicine

183

121

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Essential oils are one of the most notorious natural products used for medical purposes. Combined with their popular use in dermatology, their availability, and the development of antimicrobial resistance, commercial essential oils are often an option for therapy. At least 90 essential oils can be identified as being recommended for dermatological use, with at least 1500 combinations. This review explores the fundamental knowledge available on the antimicrobial properties against pathogens responsible for dermatological infections and compares the scientific evidence to what is recommended for use in common layman's literature. Also included is a review of combinations with other essential oils and antimicrobials. The minimum inhibitory concentration dilution method is the preferred means of determining antimicrobial activity. While dermatological skin pathogens such as Staphylococcus aureus have been well studied, other pathogens such as Streptococcus pyogenes, Propionibacterium acnes, Haemophilus influenzae, and Brevibacterium species have been sorely neglected. Combination studies incorporating oil blends, as well as interactions with conventional antimicrobials, have shown that mostly synergy is reported. Very few viral studies of relevance to the skin have been made. Encouragement is made for further research into essential oil combinations with other essential oils, antimicrobials, and carrier oils.

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Section: Essential Oil Combinationsmentioning

confidence: 99%

Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases

Orchard

Vuuren

2017

Evidence-Based Complementary and Alternative Medicine

183

121

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“…Consequently, the interruption of apoptotic pathways may facilitate the development of novel strategies to reverse or attenuate heart failure (24,25). Certain active components of GMT have been reported to have anti-apoptotic effects, and are used as a classic prescription in traditional Chinese medicine for the treatment of cardiovascular diseases (12–15). Therefore, it was speculated for the purposes of the present study that GMT could salvage these cardiocytes and prevent ischemic cell loss induced by apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…Tetrahydroxystilbene-glucoside, one of the active ingredients of F. multiflorum , has been reported to exert a protective effect on the cardiovascular system by influencing cellular antioxidant capacity and inhibiting doxorubicin-induced apoptosis in cardiomyocytes (11,12). The pharmacological effects of S. miltiorrhiza extracts include antioxidative, anti-apoptotic and vasodilatory activities, which may be affected by the inhibition of intercellular adhesion molecule 1 (ICAM-1) expression to protect endothelial function and inhibit atherogenesis, and promoting the role of S. miltiorrhiza in cardiovascular and cerebrovascular systems (13–15). In previous studies, Safflower has been demonstrated to reduce cardiovascular disease risk in rats (16,17).…”

Section: Introductionmentioning

confidence: 99%

Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction

Wang

Yang

et al. 2016

Experimental and Therapeutic Medicine

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Guanmaitong (GMT) is a traditional Chinese herbal compound that has been used for the treatment of coronary heart disease (CHD) and other cardiovascular diseases. However, the efficacy of GMT in treating cardiovascular diseases remains unclear. The aim of the present study was to investigate the protective mechanisms and identify the targeted proteins and signaling networks associated with the physiological activity of GMT in a rat model of acute myocardial infarction (AMI). Sprague-Dawley rats were randomly allocated into five groups: Control group (sham-operated), the model group, and small, medium, and large dosage GMT groups. The rat model of AMI was established via ligation of the coronary artery. The results indicate that GMT was able to reduce myocardial infarction size and improve the activities of tumor necrosis factor-α (TNF-α), intercellular adhesion molecule 1 (ICAM-1) and interleukin-1. Furthermore, the reduced apoptotic index of the GMT-treated cardiocytes (P<0.05 vs. model group) was in accordance with the downregulated expression of Bax and the upregulated expression of Bcl-2. In conclusion, GMT may exert a protective potential against myocardial infarction injury by inhibiting apoptosis and inflammation of cardiomyocytes, and may offer a promising adjunct treatment for CHD.

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“…For example, Danggui‐Shaoyao‐San, a traditional herbal formula medicine which is widely used in China, Japan and Korea, consists of six medicinal herbs, is reported to have a significant anti‐depression effect in the current clinical treatment . The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) are principle herbs of Chinese herbal formulae, which have been proven to be able to treat cardiovascular diseases effectively . In this present study, we introduce a novel Chinese herb formula, mix six well‐known Chinese medicine together, which are Speranskiae tuberculatae, Spatholobi caulis, Paeoniae radix alba, Chaenomelis fructus, Uncariae ramulus cum uncis and Angelicae sinensis radix , respectively.…”

Section: Introductionmentioning

confidence: 99%

Novel medical bathing with traditional Chinese herb formula alleviates paraplegia spasticity

Liu

Meng

et al. 2014

Int J of Nursing Practice

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Paraplegia spasm is a kind of chronic disease which lacks effective treatment; the patients have to endure long-term pain, which is a tough problem for nursing practice. Lots of potential candidate medicines are under investigation, and a new Chinese herb formula is introduced in the current study. In the present study, we chose six different well-known Chinese herbs to form a formula, and boiled them into the water with an optimized ratio to make bath water; 80 paraplegic patients received this medicinal bath, and 80 patients received perfume water bath as placebo group. Compared with placebo control patients, the herb-treated patients have significant reduction in paraplegia spasm, visual analogue scale score, clinician global impression and sleep disorder. This novel six-combined formula traditional medicine could be beneficial for alleviating paraplegia spasm, but the underlying action mechanism deserves further study.

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The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: A study of the combination effects of the 2-herb formula

Cited by 46 publications

References 34 publications

Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases

Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases

Cardioprotective effects of traditional Chinese medicine Guanmaitong on acute myocardial infarction

Novel medical bathing with traditional Chinese herb formula alleviates paraplegia spasticity

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