The Rotational Spectra of Cyanoacetylene Dimer, H-C-C-C-N ••• H-C-C-C-N

Kang, Lu; Davis, Philip W.; Dorell, Ian; Li, Kexin; Daly, Adam M.; Kukolich, Stephen G.; Novick, Stewart E.

doi:10.15278/isms.2016.wa09

Cited by 7 publications

(8 citation statements)

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“…[2] Diminished anxiety-like behavior has been reported in GF mice [5,9] and GF zebrafish. [88] Interestingly, there seems to be a divergence between behavioral and hormonal measures of the stress response in GF mice, which exhibit heightened corticosterone levels following exposure to a stressor despite their low-anxiety behavioral profile. [8,10] However, in agreement with the neuroendocrine profile, heightened anxietylike behavior has been observed in GF rats.…”

Section: Anxiety-and Depression-like Behavior Are Regulated By Gut MImentioning

confidence: 99%

“…[90,96] Finally, different probiotic strains have been shown to reduce symptoms of anxiety and depression across several studies in clinical and healthy populations. [97,98] While there have also [5,9,10,88,90] Anxiolytic effects, sometimes sex-specific, in mice (light-dark box, elevated-plus maze) [72,113] Anxiolytic effects in mice (open field, defensive marble burying, elevated-plus maze, light-dark box) [91,93] Strain-specific anxiolytic effects in humans (e.g., Beck Anxiety Index, Hospital Anxiety & Depression Scale) and rodents (defensive marble burying, elevated-plus maze, open field) [11,62,133,134] Transplant from humans with depression or comorbid IBS and anxiety increases anxietylike behavior in mice (open field, step-down test, light-dark box) [96,125] Heightened anxiety in rats (open field) [89] Depression Increased depressive-like behavior in mice (forced swim) [90] Increased depressive-like behavior in rats (forced swim) [94] Antidepressant effects in mice and rats (forced swim, tail suspension, learned helplessness after inescapable shock) [91,92] Strain-specific antidepressant effects in humans (e.g. Beck Depression Inventory, Hospital Anxiety & Depression Scale) and rodents (tail suspension test, forced swim, sucrose preference) [11,97,98,133,134] Transplant from depressed human donors induces depressive-like behavior in mice (sucrose preference, forced swim [varied results], tail suspension test) [90,96] Learned fear Impaired fear recall in adult mice [101] Acute administration enhances fear extinction in rodents and exposure therapy in humans, [103,104] reduces fear recall in huma...…”

Section: Anxiety-and Depression-like Behavior Are Regulated By Gut MImentioning

confidence: 99%

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Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

et al. 2017

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The amygdala is a key brain area regulating responses to stress and emotional stimuli, so improving our understanding of how it is regulated could offer novel strategies for treating disturbances in emotion regulation. As we review here, a growing body of evidence indicates that the gut microbiota may contribute to a range of amygdala-dependent brain functions from pain sensitivity to social behavior, emotion regulation, and therefore, psychiatric health. In addition, it appears that the microbiota is necessary for normal development of the amygdala at both the structural and functional levels. While further investigations are needed to elucidate the exact mechanisms of microbiota-to-amygdala communication, ultimately, this work raises the intriguing possibility that the gut microbiota may become a viable treatment target in disorders associated with amygdala dysregulation, including visceral pain, post-traumatic stress disorder, and beyond. Also see the video abstract here: https://youtu.be/O5gvxVJjX18

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Section: Anxiety-and Depression-like Behavior Are Regulated By Gut MImentioning

confidence: 99%

Section: Anxiety-and Depression-like Behavior Are Regulated By Gut MImentioning

confidence: 99%

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

et al. 2017

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“…These issues are compounded by the presence of backgrounds whose signals could mimic those expected from WIMPs. Although powerful techniques have been developed to discriminate and shield against a majority of these backgrounds, the misidentification of backgrounds for signal continues to plague the field [6,7,8,9]. For these reasons the definitive proof of discovery in dark matter searches rests on the detection of specific signatures of the WIMP-nucleus interaction arising from the Galactic origin of the WIMPs.…”

Section: Introductionmentioning

confidence: 99%

GEM-based TPC with CCD imaging for directional dark matter detection

Phan

Lauer

Lee

et al. 2016

Astroparticle Physics

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The most mature directional dark matter experiments at present all utilize low-pressure gas Time Projection Chamber (TPC) technologies. We discuss some of the challenges for this technology, for which balancing the goal of achieving the best sensitivity with that of cost effective scale-up requires optimization over a large parameter space. Critical for this are the precision measurements of the fundamental properties of both electron and nuclear recoil tracks down to the lowest detectable energies. Such measurements are necessary to provide a benchmark for background discrimination and directional sensitivity that could be used for future optimization studies for directional dark matter experiments. In this paper we describe a small, high resolution, high signal-to-noise GEM-based TPC with a 2D CCD readout designed for this goal. The performance of the detector was characterized using alpha particles, X-rays, gamma-rays, and neutrons, enabling detailed measurements of electron and nuclear recoil tracks. Stable effective gas gains of greater than 1 × 10 5 were obtained in 100 Torr of pure CF 4 by a cascade of three standard CERN GEMs each with a 140 µm pitch. The high signal-to-noise and sub-millimeter spatial resolution of the GEM amplification and CCD readout, together with low diffusion, allow for excellent background discrimination between electron and nuclear recoils down below ∼10 keVee (∼23 keVr fluorine recoil). Even lower thresholds, necessary for the detection of low mass WIMPs for example, might be achieved by lowering the pressure and utilizing full 3D track reconstruction. These and other paths for improvements are discussed, as are possible fundamental limitations imposed by the physics of energy loss.

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“…So, too, are biologists turning to model systems for the study of symbiosis. Fortuitously, many of the powerful models that were important for developmental biology have also been adopted for the study of host-microbe interactions, including Hydra, [6][7][8][9] the fruit fly, [10][11][12] worm, [13][14][15] zebrafish, [16][17][18] and mouse. [19,20] In addition to these systems, other model associations have come from a deep history in the field of symbiosis (e.g., the squid-vibrio symbiosis or the parasitic nematode-Xenorhabdus association) or have developed anew (e.g., sponge, starlet anemone, honey bee, leech, and gypsy moth).…”

Section: How Do Metaorganisms Develop and How Do The Interspecific Inmentioning

confidence: 99%

Evolutionary “Experiments” in Symbiosis: The Study of Model Animals Provides Insights into the Mechanisms Underlying the Diversity of Host–Microbe Interactions

2019

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Current work in experimental biology revolves around a handful of animal species. Studying only a few organisms limits science to the answers that those organisms can provide. Nature has given us an overwhelming diversity of animals to study, and recent technological advances have greatly accelerated the ability to generate genetic and genomic tools to develop model organisms for research on host-microbe interactions. With the help of such models the authors therefore hope to construct a more complete picture of the mechanisms that underlie crucial interactions in a given metaorganism (entity consisting of a eukaryotic host with all its associated microbial partners). As reviewed here, new knowledge of the diversity of host-microbe interactions found across the animal kingdom will provide new insights into how animals develop, evolve, and succumb to the disease.

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The Rotational Spectra of Cyanoacetylene Dimer, H-C-C-C-N ••• H-C-C-C-N

Cited by 7 publications

References 0 publications

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

Gutsy Moves: The Amygdala as a Critical Node in Microbiota to Brain Signaling

GEM-based TPC with CCD imaging for directional dark matter detection

Evolutionary “Experiments” in Symbiosis: The Study of Model Animals Provides Insights into the Mechanisms Underlying the Diversity of Host–Microbe Interactions

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