The Routine Use of Antibiotics to Promote Animal Growth Does Little to Benefit Protein Undernutrition in the Developing World

Collignon, Peter; Wegener, Henrik Caspar; Braam, Peter; Butler, Colin

doi:10.1086/433191

Cited by 65 publications

(23 citation statements)

References 10 publications

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“…This situation not only increases the difficulty of treating animal diseases like those caused by APEC with existing anti-microbials, but it also poses a potential threat to human health in consideration of the cross exchange of drug-resistance genes between animal and human pathogens (Collignon, Wegener, Braam, & Butler, 2005). Unfortunately, consistent with previous studies (Chen et al, 2014;Wang et al, 2016), the isolates in this study carried multiple drug-resistance genes.…”

Section: Discussionsupporting

confidence: 78%

Duck viral infection escalated the incidence of avian pathogenic Escherichia coli in China

Liu

Diao

Wang

et al. 2019

Transbound Emerg Dis

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Avian pathogenic Escherichia coli (APEC) causes high mortality in poultry flocks and often is complicated with viral infections, leading to large economic losses; however, little information is available on the epidemiological characteristics of this pathogen in ducks. Therefore, a systemic epidemiological investigation was performed on 325 duck farms from 13 provinces in China during the period of 1 April 2016 until 31 March 2018, covering 2 years. A total of 26 APEC strains were isolated from different farms in this study, and analysis showed that all of those isolates carried multiple virulence‐associated genes and drug‐resistance genes, which led to high pathogenicity (15/26), strong or moderate biofilm formation (24/26) and multidrug‐resistant abilities (26/26). On the other hand, coinfection with APEC, H9 avian influenza virus (AIV) and Tembusu virus (TMUV) was very common on those farms (11/26), with APEC and TMUV sharing a similar morbidity peak (from May to September) and susceptibility (60% infections occurred in ducklings); thus, we speculated that the emerging TMUV infection escalated the APEC incidence in ducks. Finally, the data presented in this report enhance the current understanding of the epidemiology of APEC and different viral infections in ducks and provide additional insight into the critical factors that determine their pathogenicity. Meanwhile, the emergence of multidrug‐resistant APEC strains and their coinfection with different viruses emphasize that preventive measures against such infections on poultry farms should be implemented immediately.

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Section: Discussionsupporting

confidence: 78%

Duck viral infection escalated the incidence of avian pathogenic Escherichia coli in China

Liu

Diao

Wang

et al. 2019

Transbound Emerg Dis

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“…B 370: 20140085 under modern circumstances with improved feeding regimes to compare with the situation 40-60 years ago. It has been argued that this use is essential to feed the world with animal proteins but more recent data suggest that the importance of antimicrobial growth promoters (AGPs) might be over-estimated [18][19][20][21].…”

Section: Antimicrobial Usage In Livestock Productionmentioning

confidence: 99%

The livestock reservoir for antimicrobial resistance: a personal view on changing patterns of risks, effects of interventions and the way forward

Aarestrup

2015

Phil. Trans. R. Soc. B

235

194

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The purpose of this review was to provide an updated overview on the use of antimicrobial agents in livestock, the associated problems for humans and current knowledge on the effects of reducing resistance in the livestock reservoir on both human health and animal production. There is still limiting data on both use of antimicrobial agents, occurrence and spread of resistance as well as impact on human health. However, in recent years, emerging issues related to methicillin-resistant Staphylococcus aureus , Clostridium difficile , Escherichia coli and horizontally transferred genes indicates that the livestock reservoir has a more significant impact on human health than was estimated 10 years ago, where the focus was mainly on resistance in Campylobacter and Salmonella . Studies have indicated that there might only be a marginal if any benefit from the regular use of antibiotics and have shown that it is possible to substantially reduce the use of antimicrobial agents in livestock production without compromising animal welfare or health or production. In some cases, this should be done in combination with other measures such as biosecurity and use of vaccines. To enable better studies on both the global burden and the effect of interventions, there is a need for global harmonized integrated and continuous surveillance of antimicrobial usage and antimicrobial resistance, preferably associated with data on production and animal diseases to determine the positive and negative impact of reducing antimicrobial use in livestock.

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“…Another argument used to justify antibiotics as growth promoters of food animals was that the nutrition of people in these countries will improve based on the presumption that this use will improve a populations’ protein intake. This is also unlikely to be true [ 9 ].…”

Section: Editorialmentioning

confidence: 99%

China, what antibiotics and what volumes are used in food production animals?

Collignon

Voß

2015

Antimicrob Resist Infect Control

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The Routine Use of Antibiotics to Promote Animal Growth Does Little to Benefit Protein Undernutrition in the Developing World

Cited by 65 publications

References 10 publications

Duck viral infection escalated the incidence of avian pathogenic Escherichia coli in China

Duck viral infection escalated the incidence of avian pathogenic Escherichia coli in China

The livestock reservoir for antimicrobial resistance: a personal view on changing patterns of risks, effects of interventions and the way forward

China, what antibiotics and what volumes are used in food production animals?

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