The ROVIGO Study (Risk of Vascular Complications: Impact of Genetics in Old people): Protocol, Study Design, and Preliminary Results of the Initial Survey

Mazza, Alberto; Zamboni, S; Ramazzina, Emilio; Schiavon, Laura; Rempelou, Panagiota; Zorzan, Sara; Bascelli, Anna; Segato, Rosa; Redi, Rossana; Pagnin, Elisa; Camerotto, Alessandro; Zuin, Marco; Rizzato, Enzo; Marcolongo, Adriano; Orsini, A.; Rubello, Domenico; Casíglia, Edoardo

doi:10.1007/s40292-014-0072-1

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“…The study cohort consisted of 580 unselected subjects (272 men and 308 women) aged 65 years or over, representative of the elderly of the general population of Rovigo in the Italian Veneto region. The results of the initial cross-sectional survey are described herein [6]. Data from the longitudinal analysis, including morbidity, mortality and incidence of new cases of hypertension, has not yet been published.…”

Section: Methodsmentioning

confidence: 99%

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Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population

Mazza

Lenti

Schiavon

et al. 2017

Biomedicine & Pharmacotherapy

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Objective In clinical practice, patient characteristics predicting resistant hypertension (RH) include higher blood pressure levels, left ventricular hypertrophy, older age, obesity, chronic kidney disease and diabetes. On the contrary little is known about the role of serum uric acid (SUA) as a risk factor for RH in subjects from general population. Material and methods 580 elderly subjects aged ≥65 years were enrolled in the Risk Of Vascular complications Impact of Genetics in Old people (ROVIGO) study. RH was defined as the failure to maintain blood pressure values below 140 mmHg (systolic) and 90 mmHg (diastolic) despite therapeutic interventions that include appropriate lifestyle measures plus adherence to treatment with full doses of at least three antihypertensive drugs, including a diuretic. RH was confirmed using 24-h ambulatory blood pressure measurement. Hyperuricemic was defined as the subjects having SUA ≥6.8 mg/dl or taking uricosuric drugs. Gender-specific odds ratio (OR) for RH was calculated by logistic regression analysis. Results The prevalence of RH was 5.7% in the cohort and was higher in women (8.3%) than in men (3.0%, p < 0.05). Independent of chronic kidney disease (OR 3.89, 95% confidence interval 1.49–10.1), hyperuricemia predicted resistant hypertension in women (odds ratio 3.11, 95% confidence intervals 1.06–9.1, p = 0.03) but not in men. Conclusions In elderly women from the general population, an SUA value of ≥6.8 mg/dl triples the risk of RH. SUA assessment should be recommended to better define the pattern of risk associated with RH.

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Section: Methodsmentioning

confidence: 99%

“…The protocol of the study was previously published [6] and included gathering of demographic information, medical and social questionnaires, fasting blood tests, anthropometrics, electrocardiogram, clinic BP and 24-h ambulatory BP measurements. Procedures for taking and preparing blood specimens and laboratory analysis were standardized.…”

Section: Methodsmentioning

confidence: 99%

Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population

Mazza

Lenti

Schiavon

et al. 2017

Biomedicine & Pharmacotherapy

Self Cite

View full text Add to dashboard Cite

show abstract

The ROVIGO Study (Risk of Vascular Complications: Impact of Genetics in Old people): Protocol, Study Design, and Preliminary Results of the Initial Survey

Abstract: People living in Rovigo were at lower CV risk than those in Castelfranco Veneto and Chioggia, mainly due to lower BP values, better lipid pattern and lower prevalence of CV and pulmonary disease.

Cited by 1 publication

References 25 publications

Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population

Asymptomatic hyperuricemia is a strong risk factor for resistant hypertension in elderly subjects from general population

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