The rs1277306 Variant of the <b><i>REST</i></b> Gene Confers Susceptibility to Cognitive Aging in an Elderly Taiwanese Population

Abstract

Background/Aims: There is growing evidence that the RE1-silencing transcription factor (REST) gene may contribute to cognitive aging and Alzheimer diseases. In this replication study, we reassessed whether single nucleotide polymorphisms (SNPs) within the REST gene are linked with cognitive aging independently and/or through complex interactions in an older Taiwanese population. Methods: A total of 634 Taiwanese subjects aged over 60 years from the Taiwan Biobank were analyzed. Mini-Mental State Examination (MMSE) scores were performed for all subjects to weigh cognitive functions. Results: Our data showed that the REST rs1277306 SNP was significantly associated with cognitive aging among all subjects (p = 0.0052). Furthermore, the association remained significant for individuals without APOE ε4 allele (p = 0.0092), but not for individuals with at least 1 APOE ε4 allele. This association remained significant after Bonferroni correction. Additionally, we found the interactions between the rs1713985 and rs1277306 SNPs on cognitive aging (p = 0.016). However, the 3-marker haplotype derived from the rs1713985, rs3796529, and rs7680734 SNPs in the REST gene demonstrated no association with cognitive aging. Conclusion: Our study indicates that the REST gene may contribute to susceptibility to cognitive aging independently as well as through SNP-SNP and APOE-REST interactions.

Effects of circadian clock genes and environmental factors on cognitive aging in old adults in a Taiwanese population

“…This study incorporated subjects from the Taiwan Biobank [47–49]. The study cohort consisted of 634 participants.…”

Precision Psychiatry Applications with Pharmacogenomics: Artificial Intelligence and Machine Learning Approaches

“…Although in the present review we showed some research reports to depict the related artificial intelligence and machine learning algorithms in the neurobiology of psychiatric disorders, it might be noted that precision psychiatry studies may be further improved by integrating the state-of-the-art artificial intelligence and machine learning frameworks with multi-omics and neuroimaging datasets [17]. Numerous current biobanks have been built to collect multi-omics data, such as the Taiwan Biobank [50][51][52][53][54][55][56][57], the COMBINE Biobank [58], LifeGene [59], and the Korea Healthy Twin Study [60].…”

Genetic Biomarkers on Age-Related Cognitive Decline

“…A growing body of evidence suggests that REST may be involved with AD and cognitive aging ( 62 ). A recent replication study has assessed whether REST SNPs are associated with cognitive aging as well as via SNP–SNP interactions for normal aging in elder Taiwanese subjects ( n = 634; mean age: 64.2 years) ( 62 ). Their analysis results demonstrated that REST -rs1277306 was linked with cognitive aging, which was measured by MMSE scores ( 62 ).…”

“…A recent replication study has assessed whether REST SNPs are associated with cognitive aging as well as via SNP–SNP interactions for normal aging in elder Taiwanese subjects ( n = 634; mean age: 64.2 years) ( 62 ). Their analysis results demonstrated that REST -rs1277306 was linked with cognitive aging, which was measured by MMSE scores ( 62 ). This prediction is further supported by evidence that the association remained significant for individuals without APOE ε4 allele after Bonferroni correction ( 62 ).…”

“…Their analysis results demonstrated that REST -rs1277306 was linked with cognitive aging, which was measured by MMSE scores ( 62 ). This prediction is further supported by evidence that the association remained significant for individuals without APOE ε4 allele after Bonferroni correction ( 62 ). On the other hand, the REST rs1277306 SNP was not a predicting factor for cognitive aging among individuals with at least one APOE ε4 allele ( 62 ).…”