The rs13129697 polymorphism of the SLC2A9 gene, but not rs7442295 is associated with impaired glucose tolerance/impaired fasting glucose complicated with hyperuricaemia in Han Chinese males

Abstract

Aims SLC2A9 is also known as glucose transporter9 (GLUT9) or urate efflux transporter (URAT)v1, which should be involved in the transport of glucose and uric acid. To further verify it, the correlation of the SLC2A9 polymorphisms(rs13129697,rs7442295) with T2DM, Hyperuricemia (HUA) and T2DM compared with HUA will be investigated in male Han Chinese. Methods Two SNPs of the SLC2A9, rs13129697, rs7442295, were genotyped in 285 T2DM patients, 300 HUA patients and 198 T2DM compared with HUA patients respectively through TaqMan-MGB Duplex real-time PCR, and 550 healthy subjects were selected as control group. The total 1333 subjects were all recruited from the Affiliated Hospital of Qingdao University Medical School. Results Compared with control group, the variant SNP of rs13129697 was both significantly associated with HUA group(P<0.001) and T2DM complicated HUA group(P<0.05), but not with pure T2DM group. After adjustment for age, triglyceride and cholesterol, logistic regression analysis showed that people with GT、GG genotype had lower risks of HUA(OR=0.615,95%CI: 0.432-0.877,P=0.007;OR=0.447, 95%CI:0.271-0.736, P=0.002)and T2DM complicated HUA(OR=0.578,95%CI: 0.360-0.923, P=0.022;OR=0.393,95%CI: 0.208-0.740,P= 0.004) than people with TTgenotype. However, there were no statistical significance between control group and T2DM group, HUA group, or T2DM complicated with HUA group in rs7442295 genotypes(P>0.05). Conclusion The rs13129697 polymorphism of the SLC2A9 gene, but not rs7442295 is associated with impaired glucose tolerance/impaired fasting glucose complicated with hyperuricaemia. And G allele may protect against the risk to develop HUA.

Population Study Insights Linked to Genetic Variants (rs16890979 and rs206833) and Type 2 Diabetes Control in Northern Jordan

“…Specifically, the rs13129697 SNP has correlations with triglyceride levels and gout [34]. Furthermore, the rs13129697 SNP is associated with a reduced risk of hyperuricemia in Chinese hypertensive patients [35] and is linked to impaired glucose tolerance or impaired fasting glucose complicated by hyperuricemia in Han Chinese males [23]. In the current study the minor allele frequency (MAF) of this SNP among the enrolled T2DM patients was 0.42, closely aligning with frequencies (0.42-0.49) reported in another Chinese study involving hypertensive subjects [35] and the frequency (0.478) reported on the genome-wide association studies (GWASs) catalog website (https://www.ebi.ac.uk/gwas/variants/rs13129697).…”

“…Among these SNPs, rs16890979 is strongly associated with variations in SUA levels [24,25]. Additionally, rs13129697 has been linked to impaired glucose tolerance and impaired fasting glucose complicated by hyperuricemia in diabetic Han Chinese males [23]. Given these findings, SLC2A9 SNPs (rs13129697, rs16890979) within Jordanian diabetics were the focus of the current study.…”

“…In fact, genetic variations within SLC2A9 influence UA transport, thereby impacting the UA level [22]. The SLC2A9 gene encodes the glucose transporter 9 (GLUT9) protein, which serves as a glucose and UA transporter [23]. There is evidence that SLC2A9 SNPs are susceptibility factors and have an essential role in maintaining glucose and UA homeostasis.…”