The Rubella Problem

Skinner, Clifford W.

doi:10.1001/archpedi.1961.04020020080013

Cited by 7 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…COMMENT The patients whose details are summarized in Table I have been selected because of the presence of signs of pulmonary stenosis, and therefore all have cardiovascular involvement. Their other features are in accord with the recognized effects of rubella at this stage of pregnancy (Blattner, 1959;Skinner, 1961;Pitt, 1961). In Case 2 and in Case 7 there is no clear history of rubella in pregnancy.…”

Section: Resultssupporting

confidence: 68%

The Syndrome of Pulmonary Stenosis Complicating Maternal Rubella

Venables¹

1965

Heart

View full text Add to dashboard Cite

Section: Resultssupporting

confidence: 68%

The Syndrome of Pulmonary Stenosis Complicating Maternal Rubella

Venables¹

1965

Heart

View full text Add to dashboard Cite

“…Although rubella (German measles) is usually a benign infection of children or young adults, its occurrence in women during early pregnancy causes a high frequency of congenital abnormalities of the newborn (13,15). The current strategy for rubella control is based on routine vaccination of all children .12 months of age, vaccination of all school children not immunized in infancy, and vaccination of susceptible adults, particularly females and hospital personnel (5).…”

mentioning

confidence: 99%

Rubella antibodies detected by several commercial immunoassays in hemagglutination inhibition-negative sera

Kleeman¹,

Kiefer²,

Halbert³

1983

J Clin Microbiol

View full text Add to dashboard Cite

Although a very good correlation was found between the level of rubella antibodies measured by a standard hemagglutination inhibition (HI) test and by an enzyme-linked immunosorbent assay (ELISA) procedure (Cordia R), an appreciable proportion (31%) of ELISA-positive specimens were encountered among HI-negative sera. The reverse was rarely seen. Many of the HI-negative, ELISA-positive sera were also found to be positive for rubella antibodies by one or more other assay methods, including an immunofluorescence assay (IFA) procedure (FIAX), passive hemagglutination (PHA) (Rubacell and PHAST), latex agglutination (Rubascan), and a second ELISA procedure (Rubelisa). The specificity of all of the ELISA-positive HI-negative specimens was substantiated by absorption experiments. In these tests, the ELISA reactivities were blocked by rubella antigens, but not by a variety of tissue culture control antigens or by influenza virus grown on the same cell line. The findings indicate that many of the newer methods available for rubella antibody detection are more sensitive than HI for detecting low levels of rubella antibodies. Until more clinical information is available concerning the protective nature of these low levels of antibody, caution should be exercised in assessing the significance of these results.

show abstract

Rubella Epidemic, 1964: Effect on 6,000 Pregnancies

Sever¹,

Nelson²,

Gilkeson³

1965

Am J Dis Child

View full text Add to dashboard Cite

AN EXTENSIVE epidemic of rubella occurred throughout the United States during the first six months of 1964. This epidemic was monitored by 11 institutions participating in the prospective Collaborative Study of Cerebral Palsy. In addition to the detailed clinical data obtained for all pregnant patients and their children in the study, special protocols were instituted to provide detailed information on rubella. Serial serum specimens taken throughout pregnancies were subsequently tested for antibody to rubella.The present paper presents a preliminary report of the clinical and laboratory findings available through the neonatal period. Materials and MethodsI. General Study Information.\p=m-\Thisreport is based on the experience of 6,161 pregnant women who were under study during the period of January through June 1964. These women were registered at collaborating institutions, all of them university hospitals, of which seven are along the eastern seaboard and four at scattered points over the remainder of the country, including one on the West Coast.Detailed analysis of pediatrie information through the neonatal period is presented for the children of a subgroup of 750 women who re¬ ported either clinical rubella at some time during their pregnancies or exposure to rubella during the first trimester of pregnancy without develop¬ ment of clinical disease. A later report will ex¬ tend the clinical and laboratory information for the children of patients who were exposed in the second or third trimester of pregnancy and those who did not have a history of exposure. //. Obstetrical Phase.-A. Characterization of the Sample : Patients were registered by a rou¬ tine sampling method at the collaborating insti¬ tutions. The study patients were largely an urban group of which the majority were semi-indigent clinic patients. At the time of registration, 19% were unmarried. The occupation of the main wage earner is summarized in Table 1. For the subgroup of 750 patients with clinical rubella or first trimester exposure, the mean age at the time of registration was 24.7 years (range of 13 to 44 years). The racial distribution of the subgroup and the study population which regis¬ tered in the first six months of 1964 is given in Table 2. There was a significantly greater pro¬ portion of white patients in the subgroup. Further analysis of the racial distribution of the subgroup is given in the section on Results, part II.The relatively late registration of the majority of women prevented the observation of early abor¬ tions in this sample. There was also some trunca¬ tion of the sample for late registration since no patient was accepted for the study who had not had at least one prenatal examination.B. Obstetrical Observations : Upon admission into the study, the patients were questioned ex¬ tensively as to their medical and obstetrical his¬ tories and were examined thoroughly. At each subsequent prenatal visit, the patients were again questioned and examined. Complete records of information thus obtained were forwarded to the Pe...

show abstract

The Rubella Problem

Cited by 7 publications

References 21 publications

The Syndrome of Pulmonary Stenosis Complicating Maternal Rubella

The Syndrome of Pulmonary Stenosis Complicating Maternal Rubella

Rubella antibodies detected by several commercial immunoassays in hemagglutination inhibition-negative sera

Rubella Epidemic, 1964: Effect on 6,000 Pregnancies

Contact Info

Product

Resources

About