The Rules and Norms of Leadership Succession in China: From Deng Xiaoping to Xi Jinping and Beyond

Wang, Zhengxu; Vangeli, Anastas

doi:10.1086/686141

Cited by 21 publications

(16 citation statements)

References 17 publications

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“…Palmitoylation was calculated as a ratio of signal from Streptavidin over signal from the Flag antibody. The HD88 was generated as previously described 64 by immunizing a rabbit with a synthetic peptide GFYKSREVFDPAEQ corresponding to the N-terminus of mouse Casp6. The antibody was purified by protein A and peptide affinity chromatography.…”

Section: Discussionmentioning

confidence: 99%

“…Following transfer to PVDF Immobilon-FL membranes, proteins of interest were detected using the following antibodies. CASP6 was detected with anti-DDK antibody (1:1000; Origene, Rockville, MD, USA) detecting the DDK tag, or HD91 (1:1000; in-house 64 ). For the quantification of CASP6 levels, both the full-length and ΔCASP6 bands were estimated together except for the LE22 experiment, where they were estimated separately.…”

Section: Discussionmentioning

confidence: 99%

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Palmitoylation of caspase-6 by HIP14 regulates its activation

et al. 2016

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Caspase-6 (CASP6) has an important role in axonal degeneration during neuronal apoptosis and in the neurodegenerative diseases Alzheimer and Huntington disease. Decreasing CASP6 activity may help to restore neuronal function in these and other diseases such as stroke and ischemia, where increased CASP6 activity has been implicated. The key to finding approaches to decrease CASP6 activity is a deeper understanding of the mechanisms regulating CASP6 activation. We show that CASP6 is posttranslationally palmitoylated by the palmitoyl acyltransferase HIP14 and that the palmitoylation of CASP6 inhibits its activation. Palmitoylation of CASP6 is decreased both in Hip14 −/− mice, where HIP14 is absent, and in YAC128 mice, a model of Huntington disease, where HIP14 is dysfunctional and where CASP6 activity is increased. Molecular modeling suggests that palmitoylation of CASP6 may inhibit its activation via steric blockage of the substrate-binding groove and inhibition of CASP6 dimerization, both essential for CASP6 function. Our studies identify palmitoylation as a novel CASP6 modification and as a key regulator of CASP6 activity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Palmitoylation of caspase-6 by HIP14 regulates its activation

et al. 2016

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“…Hence, institutional reforms in some cases may be driven by factional conflicts. Wang and Vangeli (2016) told an interesting story to illustrate this point. The story involves multiple party elites, and Table 6.1 briefly describes their connections and party positions.…”

Section: Party Institutionalization Driven By Factional Conflictsmentioning

confidence: 96%

“…In the leading up to the actual succession in 2012, it was apparent that Xi Jinping was chosen to be the party's new leader. The party makes sure that the heir is familiar with party general secretary's core duties by assigning him to some important positions in the party and military (Wang and Vangeli 2016).…”

Section: The Institutionalist Logicmentioning

confidence: 99%

“…On the one hand, institutions set the rules of political games and constrain factions' choices of strategies (Ma 2016). On the other hand, institutions in an authoritarian regime is often malleable, and institutional reforms can be utilized by a faction to change the game in its favor (Wang and Vangeli, 2016). The dissertation project accords with the view that factions and institutions are interdependent.…”

Section: Chapter 1: Introductionmentioning

confidence: 98%

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