Many new physics models, e.g., leptoquarks, extra dimensions, extended Higgs sectors, supersymmetric theories, and dark sector extensions, are expected to manifest themselves in the final states with hadronic jets. Novel experimental techniques, including a dedicated scouting trigger stream and advanced machine learning techniques can be employed to identify such signals. This talk presents searches in CMS for new phenomena in the final states that include jets, focusing on the most recent results obtained using the full Run-II data-set collected at the LHC.