The safety and effectiveness of rehabilitation exercises on COVID-19 patients

Abstract

Background: Corona Virus Disease 2019 (COVID-19) is spreading fast starting late 2019. It mainly affects the human respiratory system. Many reports revealed that rehabilitation exercise can improve respiratory function and relieve the pressure from diseases, but there is no evidence to prove its effects on COVID-19. This protocol of systematic review and meta-analysis will clarify the safety and effectiveness of rehabilitation exercises on different COVID-19 patients. Methods and analysis: Related studies will be retrieved from Web of Science, Cochrane Library, PubMed, Chinese Biomedical Literature Database, Chinese National Knowledge Infrastructure, Chinese Scientific Journal Database, Wan fang Database, ClinicalTrials, WHO Trials, and Chinese Clinical Trial Registry. Pre-defined inclusion and exclusion criteria will be used by two researchers independently for extracting data from literatures. Clinical recovery time and effective rates will be assessed as the primary outcomes. Changes of patient's condition, pulmonary function, respiratory function and activity of daily living will be assessed as the secondary outcomes. Fixed effect model will be used for evaluating efficiency. Considering clinical heterogeneity, random effect model will be used for continuous outcomes. Funnel charts, subgroup analysis and sensitivity analysis will be used to explore sources of heterogeneity. Endnote X9.3 will be used to manage data screening. The statistical analysis will be completed by RevMan5.2 and Stata/SE 15.1 software. Result: This study will assess effects and safety for practicing rehabilitation exercises on COVID-19 patients. Conclusion: The conclusion of this study will provide evidence to prove the safety and effectiveness of rehabilitation exercises on COVID-19 patients.

Cardiopulmonary Rehabilitation in Long-COVID-19 Patients with Persistent Breathlessness and Fatigue: The COVID-Rehab Study

“…Altogether, currently, specific rehabilitation guidelines for long-COVID-19 patients are not available. Studies are needed to assess the effectiveness of programs and their safety [ 43 , 44 ]. The expertise of cardiopulmonary-rehabilitation services should also be considered [ 45 ].…”

“…However, the “cardiorespiratory-exercise” profiles seem quite varied and also include patients who do not report a reduction in their performance (in comparison with the theoretical values according to age) [ 37 ]. On the other hand, the effect of cardiopulmonary-rehabilitation programs on long-COVID-19 patients is under investigation, but data are not yet available [ 43 ]. In total, the calculation of the required number of subjects is intricate.…”

A atividade física influencia do desfecho clínico em pacientes com COVID-19? Uma revisão narrativa

“…Se o exercício de reabilitação puder ajudar no tratamento com COVID-19 ou melhorar a função respiratória e prevenir seus danos, beneficiará os pacientes e aliviando muito a pressão médica. Existem algumas complicações cardíacas tardias potenciais de COVID-19 que devem ser consideradas no retorno ao exercício após COVID-19, incluindo miocardite, devido ao risco de arritmias malignas e morte súbita (Gu et al, 2020).…”

The role of exercise in rehabilitation of discharged COVID-19 patients

“… 37 , 38 , 39 , 40 The reports demonstrated the safety and effectiveness of rehabilitation exercise for different COVID-19 patients. 41 Filgueira et al 42 discussed the effect of physical activity on the immune defense mechanism and its contribution to alleviating severe inflammatory response mediated by SARS-CoV-2. Tang et al found the dyspnea was alleviated of COVID-19 patients after 4 weeks of Liuzijue exercise.…”