The Safety and Efficacy of Linezolid and Daptomycin as an Additive in Optisol-GS Against Methicillin-Resistant Staphylococcus aureus

Li, Jennifer; Feiz, Vahid; Vieira, Ana Carolina; Davis-Boozer, David; Polage, Christopher R.

doi:10.1097/ico.0b013e318226c6b3

Cited by 3 publications

(10 citation statements)

References 40 publications

(54 reference statements)

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“…The main characteristics of the included studies, such as storage conditions, time and temperature ranges, the comparative distinct exposition media, and the assessment methods are shown in Table 4. Of the 14 included studies, 13 evaluated the effect of preservation in human corneas [5,12,[22][23][24][25][26][27][28][29][30][31][32]; 1 study was performed with rabbit cornea for a preclinical evaluation of new intermediate storage media with simple formulations [8].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Optisol-GS was compared with seven distinct commercial media: Chen medium [31], Cornea Cold medium [13], Cornisol [22], Dexsol [25], Eusol-C [27], Kerasave [30,32], and Sinasol [26]. Optisol-GS was also compared with other compositions, such as a coconut water-based solution [23], Optisol-GS supplemented with antibiotics [24,28,29,33], and a minimum essential medium (MEM) with supplements [33].…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Regarding the corneal preservation, experimental times ranged from 1 to 28 days. The most investigated experimental times were 7 days [13,[20][21][22][23][24][25][26][28][29][30][31]34], and 14 days [13,22,24,26,28,30,34]. The mainly reported hypothermic temperature was 4 • C [8,[24][25][26][27]29,[31][32][33] (Table 4).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The most investigated experimental times were 7 days [13,[20][21][22][23][24][25][26][28][29][30][31]34], and 14 days [13,22,24,26,28,30,34]. The mainly reported hypothermic temperature was 4 • C [8,[24][25][26][27]29,[31][32][33] (Table 4). The shape and boundaries of the EC of each donor pair appeared to be similar.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The most assessed quantitative parameter was the viable endothelial cell density (ECD) (Table 7) employed in nine of the studies [13,22,24,26,27,[29][30][31][32]. Corneas (769) were evaluated by specular microscopy [13,22,26,32,34].…”

Section: Cornea Preservation Quantitative Parametersmentioning

confidence: 99%

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Cold Storage Media versus Optisol-GS in the Preservation of Corneal Quality for Keratoplasty: A Systematic Review

et al. 2022

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Optisol-GS is the most widely used pharmaceutical composition to preserve corneas for transplantation. This systematic review investigated the effects of different cold corneal storage media (CCSM) compared with Optisol-GS on the quality of stored corneas. The literature was searched throughout May 2022 on six databases and grey literature. Studies including corneas (population) exposed to distinct cold storage media (exposure) and Optisol-GS (comparison) that reported qualitative and/or quantitative parameters of cornea quality (outcome) were included. Methodological quality was assessed using ToxRTool. From 4520 identified studies, fourteen were included according to the eligibility criteria, comprising 769 evaluated cornea samples comparing Optisol-GS with commercial and noncommercial media. All studies showed good methodological quality. Experimental times ranged from 1–28 days, mainly using 4 °C as the preservation temperature. Viable endothelial cell density (ECD) and endothelial cell morphology (EC) were the most assessed parameters. ECD results for Cornisol were higher than Optisol-GS in 10 days (p = 0.049) and favored Cornea ColdTM up to 4 weeks (p < 0.05), which also showed better qualitative results. While the standardization of test protocols could improve comparisons, evidence indicates that most CCSM present similar performances on cornea preservation for transplantation at seven days, while some formulations may increase preservation at extended times.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Cornea Preservation Quantitative Parametersmentioning

confidence: 99%

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Cold Storage Media versus Optisol-GS in the Preservation of Corneal Quality for Keratoplasty: A Systematic Review

et al. 2022

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A Comprehensive Review of Donor Corneal Preservation Strategies

Cipolla,

Jo,

Sabater

2024

Cornea

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Successful corneal transplantation relies on the viability of the corneal endothelium. Although various preservation systems have been developed in the field of eye banking, long-term storage of the corneal endothelium poses challenges and is costly. Optisol-GS in the past has been the most commonly used solution for intermediate-term corneal storage in the United States. However, disruptions in the availability of Optisol-GS, caused by rising costs and supply shortages, have necessitated alternative methods of corneal preservation. Previously described preservation methods include hypothermia (2–8°C) for short-term storage (7–14 days), organ culture (28–37°C) for intermediate storage (4–7 weeks), and cryopreservation for longer-term storage. In this review, we examine standard practice and alternative methods for corneal storage.

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