Pain management in the context of pediatric palliative care can be challenging. The present article reviews, through a case-based presentation, the nonpharmacological and pharmacological methods used to ensure adequate pain control in children facing end of life. Details on the impressive range of opioid dosages required and routes of administration are highlighted from published literature and clinical experience. Where available, evidence-based recommendations are provided. Potential side effects of pain medication and barriers to good pain control are discussed. Novel analgesics and innovative delivery methods are presented as future tools enhancing pain relief at the end of life. Some challenges to ethically grounded research in this important context of care are reviewed. A lthough applicable to pain management and palliative care broader than that faced at the end of life, the present article is largely focused on this narrower context of care. Pediatric palliative care is defined as the active and total approach to care, embracing physical, psychological and spiritual elements, focusing on enhancement of quality of life for the child and support for the family (1). It is not limited to end-of-life or terminal care but rather has a broader, more inclusive approach and integrates palliative care concurrently with curative-oriented goals. There is a wide range of lifethreatening diseases affecting children, and the palliative care team may be involved for years. The present article focuses on the management of pain at the end of life, which may extend from days to months. The understanding necessary within the team to ensure excellence when caring for infants, children and adolescents at the end of life is highlighted. Aspects of pain assessment are largely addressed by other authors within this special section of Pain Research & Management.Children of all countries are faced with life-threatening conditions. In North America, more than one-half of pediatric deaths occur in children younger than one year of age, with congenital malformations, chromosomal abnormalities, and disorders related to prematurity or low birth weight constituting the main causes (2). For the older population of children, unintentional injuries and homicide are the main causes of death, where the lack of time or the context may preclude the inclusion of palliative care (2). The next largest grouping of illnesses resulting in childhood death is cancer (2), followed by a myriad of diverse conditions. There is a paucity of data in the literature about the main symptoms experienced by children whose deaths are disease related.In a United States-based study (3) of children who died of cancer, the four main symptoms reported in the last month of life were fatigue, pain, dyspnea and poor appetite. Of more than 80% of the children having pain, relief was achieved in only 27% of the cases. A similar study from Australia (1) examined symptom prevalence and characteristics in 30 inpatients whose deaths were predominantly secondary to cancer. The...