The Safety and Efficacy of p CAR-19B, a Scfv Humanlized CD19-Directed CAR-T for Patients with Relapsed/Refactory (R/R) CD19+ B-ALL

Hong, Zhenya; Liu, Yang; Zhou, Xiaoxi; Wang, Gaoxiang; Zhou, Mi; Zhang, Yingzi; Zhang, Peiling; Huang, Jinjin; Li, Meng; Ruan, Haitao; Xiao, Min; Li, Yunyan; Wang, Linling; Wang, Meiling; Zhu, Wenwu; Zhang, Qianzhen; Shen, Junjie; Zhou, Jianfeng; Qian, Cheng; Huang, Liang

doi:10.1182/blood-2022-162134

Cited by 5 publications

(8 citation statements)

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“…All these values are within range of each other despite the type of metal employed. When comparing with other researchers, [33,34] who have reported to produce ammonia from water, the synthesis rate of 2.67 mmol gcat -1 h -1 from N2/water has been observed over the noble catalyst Ru/MgO at a N2 feed of 100 sccm and Vp-p of 8.23 kV. From our prepared catalysts, Co/SiO2, displays a comparative performance in terms of ammonia synthesis rate when employing N2 and sea water vapor at a N2 feed of 6.2 sccm and power of 2 W (about Vp-p of 4.12 kV) with a value of 3.7 mmol gcat -1 h -1 .…”

Section: (A)and(b))mentioning

confidence: 75%

“…The achieved fundamental understanding on the effects of different catalysts, plasma-catalyst synergisms, and energy efficiency on ammonia synthesis allow us to primarily estimate the great potential of ammonia synthesis from N2 and "green" H2 sources, which is an important step to achieve zero-carbon ammonia synthesis. Zhang and co-workers have pioneer the substitution of H2 by water [33,34] for plasma-assisted ammonia synthesis over a notable supported Ru catalyst and obtain an ammonia synthesis rate of around 2.7 mmol.gcat -1 .h -1 . However, much needs to be done in this respect, especially when exploring less costing materials that can show enhanced behaviour in plasma environments.…”

Section: Introductionmentioning

confidence: 99%

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Sustainable ammonia synthesis from nitrogen wet with sea water vapor by single-step plasma catalysis

Gorky

Guthrie

Carreon

2022

Preprint

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Ammonia synthesis at ambient conditions employing intermittent distributed green sources of energy and feedstocks is globally sought to replace the centralized Haber-Bosch (H-B) process operating at high temperature and pressure. We report herein for the first time an effective and sustainable ammonia synthesis pathway from N2 wet with seawater vapor over spherical SiO2 and M/SiO2 (M: Ag, Cu, and Co) catalysts driven by non-thermal plasma (NTP). Experimental results indicate that the presence of a catalyst is required for ammonia production from seawater vapor and N2. The Co/SiO2 catalyst delivered the highest ammonia synthesis rate rNH3 of 3.7 mmol.gcat-1.h-1 and energy yield of 3.2 g-NH3.kW-1.h-1 at a relatively low input power of 2 W. The extraction of H atoms from H2O molecules plays an important role in the ammonia synthesis from seawater vapor. This work unfolds a novel platform for the subsequent optimization of sustainable ammonia production from endless resources such as seawater and N2 through catalytic non-thermal plasma potentially powered by renewable sources.

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Section: (A)and(b))mentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Sustainable ammonia synthesis from nitrogen wet with sea water vapor by single-step plasma catalysis

Gorky

Guthrie

Carreon

2022

Preprint

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“…Recently, researchers have exploited spatiotemporal differentiators based on metasurfaces [66][67][68] and multilayered structures, [69] which are much more compact than traditional pulse shapers [70,74,75] with indispensable spatiotemporal Fourier transform components, to generate spatiotemporal optical vortices (STOVs) with transverse OAM. In Section S2 (Supporting Information), we show that our first-order spatiotemporal differentiator can not only give rise to the spatial and temporal profiles of a single rectangular-shape pulse input but also stamps a transverse OAM with a fractal topology charge number (l = 0.58) for the output pulse.…”

Section: Discussionmentioning

confidence: 99%

Electromagnetic Spatiotemporal Differentiation Meta‐Devices

Zhou,

Zhan,

et al. 2023

Laser & Photonics Reviews

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Spatiotemporal optical computing devices that can perform mathematical operations in both spatial and temporal domains can provide unprecedented measures to build efficient and real‐time information processing systems. It is particularly important to realize the comprehensive functions in a compact design for better integration with electronic components. In this work, an analog spatiotemporal differentiator in microwaves based on an asymmetrical metasurface that has a phase singularity in the spatiotemporal domain is experimentally demonstrated. It is shown that this structure can give rise to a spatiotemporal transfer function required by an ideal first‐order differentiator in both spatial and temporal domains by tailoring the unidirectional excitation of spoof surface plasmon polaritons (SSPPs). The spatial edge detection is performed utilizing a metallic slit, and the temporal differentiation capability of the device is examined by Gaussian‐like temporal pulses of different widths. It is further confirmed that the differentiator demonstrated here can detect sharp changes in spatiotemporal pulses even with intricate profiles and theoretically estimated the resolution limits of the spatial and temporal edge detection. It is also shown that the pulse input after passing the spatiotemporal differentiator implemented here could carry a transverse orbital angular momentum (OAM) with a fractal topology charge.

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“…[21] In recent years, there has been a growing research focus on spatiotemporal analogue optical computing, which enables the implementation of mathematical operations in both spatial and temporal domains, presenting an intriguing avenue of exploration. [22][23][24][25][26][27][28][29][30][31][32][33][34][35] By leveraging the flexible optical modulation capabilities of multilayer structures [22][23][24][25][26][27][28] or metamaterials, [29][30][31][32][33][34][35] spatiotemporal analogue optical signal processors offer the potential to significantly enhance channel width and parallel processing capabilities. In addition to the widely used edge detection function in optical signal processing, first-order spatiotemporal optical differentiators have also been discovered, capable of generating optical vortices with transverse orbital angular momentum.…”

Section: Doi: 101002/adom202300746mentioning

confidence: 99%

“…In addition to the widely used edge detection function in optical signal processing, first-order spatiotemporal optical differentiators have also been discovered, capable of generating optical vortices with transverse orbital angular momentum. [27,28,[33][34][35] These optical vortices hold great promise in applications such as optical manipulation, lightmatter interactions, and quantum optics. [36] Researchers have demonstrated reconfigurable analogue optical signal processors by utilizing the tunability of phase-change materials, [21,[37][38][39] mechanical elements, [40] humidity-sensitive hydrogel, [41] liquid crystals, [42][43][44] and graphene structures.…”

Section: Doi: 101002/adom202300746mentioning

confidence: 99%

Reconfigurable Spatiotemporal Optical Signal Processors

Zhou

Zhan

Shao

et al. 2023

Advanced Optical Materials

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Analogue optical computing offers a promising approach for developing super‐fast computation techniques, benefiting from its extraordinary parallel processing capability, low energy consumption, and high integrability compared to digital electronic technologies. In this work, a reconfigurable spatiotemporal optical signal processor using the phase‐change material vanadium dioxide (VO2) to further expand the processing bandwidth and enrich the operation functions is demonstrated. As a specific example, a meta‐device is designed that can switch between a first‐order differentiator and a good reflector in the spatiotemporal domain by controlling the operation temperature. It is shown that the spatiotemporal transfer functions can be precisely engineered to meet the requirements for ideal first‐order differentiation and bright‐field imaging. This approach enables high‐accuracy spatial and temporal signal processing, as demonstrated by inspecting Gaussian signals. The theoretical evaluation determines the resolution limits of spatial and temporal edge detection. It also highlights that the device can perform spatiotemporal signal processing for pulses with complex profiles. The presented reconfigurable spatiotemporal optical signal processor holds great potential in applications such as remote sensing and fast imaging processing, among others.

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The Safety and Efficacy of p CAR-19B, a Scfv Humanlized CD19-Directed CAR-T for Patients with Relapsed/Refactory (R/R) CD19+ B-ALL

Cited by 5 publications

References 0 publications

Sustainable ammonia synthesis from nitrogen wet with sea water vapor by single-step plasma catalysis

Sustainable ammonia synthesis from nitrogen wet with sea water vapor by single-step plasma catalysis

Electromagnetic Spatiotemporal Differentiation Meta‐Devices

Reconfigurable Spatiotemporal Optical Signal Processors

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