The Safety of Oral Ketoconazole in the Treatment of Skin Diseases (Single Blinded, Therapeutic, Comparative Study)

Sharquie, Khalifa E.; Noaimi, Adil A.; Al-Salam, Wasnaa S.

doi:10.4236/jcdsa.2018.84028

Cited by 2 publications

(1 citation statement)

References 19 publications

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“…As antimycotic lipophilic drug, ketoconazole is used in medical treatment of various skin disorders and against fungal infections, available in free form such as tablet, shampoo, and cream. [10][11][12] The ketoconazole side effects and decreased stability influenced by chemical, thermal, oxidative, and acidic conditions are the main requests leading in development new formulations and structures. 13 Main challenges are vesicular systems, which are able to meet the needs of drugs i.e.…”

Section: Introductionmentioning

confidence: 99%

Preparation of Ketoconazole Liposomes with an Ultrasonic and an Injection Method Using Vegetable Oils

Popovska¹,

Simonovska²,

Kavrakovski³

et al. 2020

IJPER

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Section: Introductionmentioning

confidence: 99%

Preparation of Ketoconazole Liposomes with an Ultrasonic and an Injection Method Using Vegetable Oils

Popovska¹,

Simonovska²,

Kavrakovski³

et al. 2020

IJPER

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Leishmania Recidivans Could Be Induced by Intralesional Infiltration of Cutaneous Leishmaniasis by Sodium Stibogluconate, with New Therapeutic Trial

Sharquie

Jabbar

2022

J CLIN EXP INVEST

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Leishmania recidivans is a chronic form of cutaneous leishmaniasis with characteristic picture. So the aim of this study is to record all cases of leishmania recidivans that had history of therapy of cutaneous leishmaniasis by sodium stibogluconate.Patients and methods: This is case series descriptive study and interventional therapeutic. Twenty-two patients with clinical picture of leishmania recidivans were included. All gave a history of cutaneous leishmaniasis of 2-4-month duration before the time of therapeutic injection with sodium stibogluconate. They were treated by intralesional injections of sodium stibogluconate for several times and every two weeks and months to years before the present presentation and examination. Patients were treated by combination of oral ketoconazole, oral zinc sulfate and topical 15-25% podophyllin for around 1-2 months.Results: Twenty-two patients were evaluated, their ages ranged from 1-20 years with a median of 10 years, with 16 (72.72%) males and 6 (27.27%) females. The location of lesions was mostly on the face and upper limbs. On examination, there were ill-defined plaques with clearing at the centers leaving some atrophy and scarring at the centers of lesions while there were active dusky red papules and nodules at periphery of primary lesion. The response to therapeutic regime was obvious after three weeks and was marked after one month and almost complete clearance at 2 months. Conclusions:This work showed a new explanation for leishmania recidivans evolution as intralesional therapy of cutaneous leishmaniasis had induced leishmania recidivans. Oral ketoconazole and zinc sulfate combined with topical podophyllin are effective modes of treatment for leishmania recidivans.

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The Safety of Oral Ketoconazole in the Treatment of Skin Diseases (Single Blinded, Therapeutic, Comparative Study)

Cited by 2 publications

References 19 publications

Preparation of Ketoconazole Liposomes with an Ultrasonic and an Injection Method Using Vegetable Oils

Preparation of Ketoconazole Liposomes with an Ultrasonic and an Injection Method Using Vegetable Oils

Leishmania Recidivans Could Be Induced by Intralesional Infiltration of Cutaneous Leishmaniasis by Sodium Stibogluconate, with New Therapeutic Trial

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