The same exhaustible multilineage precursor produces both myeloid and lymphoid cells as early as 3-4 weeks after marrow transplantation.

Abstract

ABSTRACT

Transplanted Hematopoietic Cells Seed in Clusters in Recipient Bone Marrow In Vivo

“…Those cells that retain fluorescence for long periods after transplantation are nondividing cells and may represent the subpopulation with long-term reconstituting potential, which is quiescent for periods of weeks in the murine BM [11,[38][39][40]. Although the concentration of dye we used in this study would allow monitoring of several divisions, we did not attempt to quantify cellular proliferation.…”

Hematopoietic stem cells: concepts, definitions, and the new reality

“…[103][104][105][106][107] Additional deviations from a unilinear branching model of hematopoietic cell differentiation from a single original compartment include examples of a very rapid loss of LTRC properties with full retention of viability and proliferative responsiveness in vitro 65 or a rapid differentiation of their progeny into mature cells in vivo. 93,108 Also of note is the suggestion that the unexpectedly accelerated differentiation profiles exhibited by some cells with an LTRC phenotype may be related to their particular "poised" or "primed" gene expression state-as reflected in their expression of certain lineage-specific genes at a low level. 101,109,110 Physiological relevance of LTRCs…”

SCL is required for normal function of short-term repopulating hematopoietic stem cells

“…2 LT-HSCs give rise to ST-HSCs and MPPs, which have limited self-renewal capacity but can rapidly provide multilineage repopulation of lethally irradiated recipients. [3][4][5][6] Early engraftment by multilineage progenitors is an important but poorly understood process that requires homing to the spleen and bone marrow, rapid proliferation, and multilineage differentiation within the first few weeks after transplantation.…”