The SAMMPRIS trial: the end or just the beginning

Symptom Differences and Pretreatment Asymptomatic Interval Affect Outcomes of Stenting for Intracranial Atherosclerotic Disease

“…Additionally, multiple prior studies demonstrated that complication rates increase the sooner intervention is performed with relation to most recent symptoms, probably related to stability of atherosclerotic plaques. 10,22,40,47 We posit that such concerns relate to unstable plaques that would be expected to cause primarily nonhypoperfusion symptoms, for example, embolization distal to the plaque or perforator occlusion adjacent to the plaque. In the current study, lesions causing nonhypoperfusion symptoms within 7 or 14 days of treatment were associated with stroke by point of last contact.…”