Abstract:Plus ça change, plus c'est la même chose" -the more things change, the more they stay the same. Jean-Baptiste Alphonse Karr (1808-1890) Calls for a standardised definition and approaches to the investigation of unexpected infant death have been made for decades. 1,2 It is now 20 years since an expert committee was convened in San Diego by Dr Henry Krous under the auspices of the CJ Foundation for SIDS (in January 2004) to examine the then current definitions of sudden infant death syndrome (SIDS) and to propos… Show more
“…Sudden infant death syndrome (SIDS) is the sudden and unexpected death of a healthy child under one year of age, usually during sleep. The cause of SIDS is still unknown, but many risk factors have been identified, including prematurity [ 93 , 94 , 95 , 96 , 97 ].…”
Neurotrophins (NTs) are four small proteins produced by both neuronal and non-neuronal cells; they include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NTs can exert their action through both genomic and non-genomic mechanisms by interacting with specific receptors. Initial studies on NTs have identified them only as functional molecules of the nervous system. However, recent research have shown that some tissues and organs (such as the lungs, skin, and skeletal and smooth muscle) as well as some structural cells can secrete and respond to NTs. In addition, NTs perform several roles in normal and pathological conditions at different anatomical sites, in both fetal and postnatal life. During pregnancy, NTs are produced by the mother, placenta, and fetus. They play a pivotal role in the pre-implantation process and in placental and embryonic development; they are also involved in the development of the brain and respiratory system. In the postnatal period, it appears that NTs are associated with some diseases, such as sudden infant death syndrome (SIDS), asthma, congenital central hypoventilation syndrome (CCHS), and bronchopulmonary dysplasia (BPD).
“…Sudden infant death syndrome (SIDS) is the sudden and unexpected death of a healthy child under one year of age, usually during sleep. The cause of SIDS is still unknown, but many risk factors have been identified, including prematurity [ 93 , 94 , 95 , 96 , 97 ].…”
Neurotrophins (NTs) are four small proteins produced by both neuronal and non-neuronal cells; they include nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). NTs can exert their action through both genomic and non-genomic mechanisms by interacting with specific receptors. Initial studies on NTs have identified them only as functional molecules of the nervous system. However, recent research have shown that some tissues and organs (such as the lungs, skin, and skeletal and smooth muscle) as well as some structural cells can secrete and respond to NTs. In addition, NTs perform several roles in normal and pathological conditions at different anatomical sites, in both fetal and postnatal life. During pregnancy, NTs are produced by the mother, placenta, and fetus. They play a pivotal role in the pre-implantation process and in placental and embryonic development; they are also involved in the development of the brain and respiratory system. In the postnatal period, it appears that NTs are associated with some diseases, such as sudden infant death syndrome (SIDS), asthma, congenital central hypoventilation syndrome (CCHS), and bronchopulmonary dysplasia (BPD).
“…It is now 20 years since the San Diego definition of sudden infant death syndrome (SIDS) was proposed and Byard and Tan carried out a timely examination of the impact of this consensus statement. Their review of the literature showed that the definition has not been uniformly applied and that a diagnostic shift had occurred, with the term ‘undetermined’ being used in preference to a diagnosis of SIDS 7 . The authors point out that this will make it difficult to interpret conclusions related to SIDS research and accurately monitor trends in SIDS mortality.…”
Section: Sudden Infant Death Syndrome Definitions Are Not Being Unifo...mentioning
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