The sap from Euphorbia peplus is effective against human nonmelanoma skin cancers

Ramsay, Jonathan; Suhrbier, Andreas; Aylward, James; Ogbourne, Steven M.; Cozzi, Sarah-Jane; Poulsen, Michael; Baumann, Kathryn; Welburn, Peter; Redlich, G. L.; Parsons, Peter G.

doi:10.1111/j.1365-2133.2010.10184.x

Cited by 68 publications

(77 citation statements)

References 14 publications

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“…Ingenol-3-angelate (ingenol mebutate, PEP005) is a PKC activator effective clinically against actinic keratosis, squamous cell carcinoma, and basal cell carcinomas (Anderson et al, 2009;Hampson et al, 2005;Ramsay et al, 2011;Siller et al, 2009Siller et al, , 2010. In melanoma cells, ingenol-3-angelate can induce senescence, apoptosis, or necrosis in a PKC-dependent manner depending on the drug concentration (Cozzi et al, 2006;Gillespie et al, 2004).…”

Section: Protein Kinase C Activators As Therapeutics For Melanomamentioning

confidence: 99%

Specifying protein kinase C functions in melanoma

Denning

2012

Pigment Cell Melanoma Res

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SummaryThe protein kinase C (PKC) family of serine/threonine protein kinases is a heterogeneous group of enzymes receiving and integrating signals involved in both normal melanocyte biology and melanoma pathology. Alterations in PKC enzyme expression and activation contribute to the malignant phenotype of melanoma in both oncogenic and tumor suppressive roles. Delineating the diverse and often context‐dependent functions of PKC enzymes in melanocyte/melanoma biology is key to capitalize on these kinases as drug targets. This review summarizes several of the diverse functions of PKC in melanocyte and melanoma biology with a focus on PKC enzyme regulation and function.

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Section: Protein Kinase C Activators As Therapeutics For Melanomamentioning

confidence: 99%

Specifying protein kinase C functions in melanoma

Denning

2012

Pigment Cell Melanoma Res

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“…Its milky sap has long been used as a remedy for treatment of skin cancer especially non-melanoma skin cancer and the active compounds have been determined to be diterpene esters Ramsay et al (2011).…”

Section: Discussionmentioning

confidence: 99%

“…Euphorbia peplus L. is primarily domestic to Europe and North Africa (Zhi-Qin et al, 2010). Its milky sap has long been used as a treatment for skin cancers especially non-melanoma skin cancer (NMSC) and the active ingredients have been established as diterpene esters (Ramsay et al, 2011). Adedapo et al (2003) explored that the aqueous extract of E. hirta caused diverse amount of testicular disintegration as well as decrease in the mean seminiferous tubular diameter in the treated rats.…”

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confidence: 99%

Estimation of Toxic Hazards Caused by Methanolic Extract of Euphorbia peplus in Male Albino Rats

Moustafa¹,

Mohammed²,

Hadeed³

et al. 2015

Adv. Anim. Vet. Sci.

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| Euphorbiaceae family presents some pharmacological activities that its latex can be used widely in the traditional medicine as a germicide, antiparasitic and in asthma and cough healing. Although the huge amount of literatures that discuss the beneficial and therapeutic uses of Euphorbia, attention had hardly paid to the adverse effects of the latex of this family. Euphorbia peplus (petty spurge or milkweed) is a species of Euphrbia that native to North Africa where it typically grows in the cultivated lands and gardens. This study was aimed to explore the toxic hazards of Euphorbia peplus latex in male albino rats using different assays including estimation of testosterone and leutinizing (LH) hormones , liver enzymes, total protein and the antioxidant enzymes superoxide dismutase and glutathione reductase in serum samples. Also, studying the effect of plant latex on testicular and liver tissue DNA fragmentation. The plant was stored in 95% methanol at room temperature for extraction of the plant. The oral administration of 500mg/kg b.wt of plant latex twice weekly for 65 days revealed a significant reduction in weight of testis and seminal vesicle with a significant decrease in sperm cell concentration and sperm motility as compared with control group. Meanwhile, the percentage of sperm abnormalities was significantly increased. Serum levels of testosterone and LH hormones were significantly decreased. The antioxidant enzymes superoxide dismutase, glutathione reductase and catalase showed a significant decrease. The latex provoked an obvious DNA damage and fragmentation in both testicular and hepatic tissues after oral treatment with euphorbia peplus latex as compared to control group.

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“…The lowest calcium, magnesium and fine sand content was recorded in this group. E. peplus was reported by many authors to have therapeutic effect and its secondary metabolites can work as anti skin cancer (Ramsay et al (2011);Hua et al (2017) and lishmanicidal (Amin et al, 2017). Ates and Tekeli (2007) reported the salinity tolerance of T. resupinatum.…”

Section: Group 4: Euphorbia Peplus -Trifolium Resupinatummentioning

confidence: 99%

Habitat diversity and plant indicators of El-Harra Oasis, Western Desert, Egypt

Elsaied¹

2017

Int. J. Adv. Res. Biol. Sci

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Habitat diversity is one of the attractive concepts in ecology that reflects the wellbeing of ecological systems. A total of 30 stands were chosen to represent habitat diversity of El-Harra Oasis. Poaceae, fababceae and astraceae were the most common families with 33 species out of 79 species belonging to 29 families. Therophytes and Hemicryptophytes were the most common life forms with 72 % of the species recorded. Chorology of all non-cultivated taxa was investigated. Species richness, Shannon and Simpson diversity indices and evenness was calculated for each stand. Eighteen soil parameters were investigated and results showed large variation among stands. Seven vegetation groups were obtained from the Two-way cluster analysis classification. Environmental parameters correlation with vegetation groups were determined using DCA and DCCA. Significant factors were detected by one way analysis of variance among the seven vegetation groups. Results showed that soil salinity indicators, soil moisture content and soil particles were the most critical factors affecting the ecological diversity in El-Harra Oasis. Indicator species of the seven habitats were halotolreants or halophytes. Managing water resources and agriculture schemes should reduce the magnitudes of salinity problem in El-Harra Oasis.

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The sap from Euphorbia peplus is effective against human nonmelanoma skin cancers

Cited by 68 publications

References 14 publications

Specifying protein kinase C functions in melanoma

Specifying protein kinase C functions in melanoma

Estimation of Toxic Hazards Caused by Methanolic Extract of Euphorbia peplus in Male Albino Rats

Habitat diversity and plant indicators of El-Harra Oasis, Western Desert, Egypt

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