The SARS-CoV-2 outbreak: What we know

Abstract

Highlights  the latest summary of the COVID-19 outbreak in China;  there might be an oral-fecal transmission of the virus;  aggregates and consolidates the epidemiology, clinical manifestations, diagnosis, treatments and preventions of this new type of coronavirus. AbstractThere is a current worldwide outbreak of the novel coronavirus Covid-19 (coronavirus disease 2019; the pathogen called SARS-CoV-2; previously 2019-nCoV), which originated from Wuhan in China and has now spread to 6 continents including 66 countries, as of 24:00 on March 2, 2020.Governments are under increased pressure to stop the outbreak spiraling into a global health emergency. At this stage, preparedness, transparency, and sharing of information are crucial to risk assessments and beginning outbreak control activities. This information should include reports from outbreak site and from laboratories supporting the investigation. This paper aggregates and consolidates the epidemiology, clinical manifestations, diagnosis, treatments and preventions of this new type of coronavirus.

The anti-viral facet of anti-rheumatic drugs: Lessons from COVID-19

“…Since COVID-19 has some clinical similarities eventually progressing in the 15% of cases in ARDS, acute cardiac injury and acute kidney disease requiring ICU monitoring and a key role seems played by IL-6 that is markedly elevated along with TNF-α, IFN-γ, IL-2, IL-10, IL-8 and granulocyte macrophage-colony-stimulating factor (GM-CSF), the use of Tocilizumab (IV 8 mg/kg i.v.) was proposed [252][253][254].…”

Risk Communication During COVID-19

“…The novel coronavirus disease 2019 , caused by the pathogen severe acute respiratory syndrome (SARS) coronavirus 2, originated in Wuhan, China and more than 2.3 million cases and more than 164,000 deaths internationally. 1,2 Within the United States, the Institute for Health Metrics and Evaluation has predicted this pandemic to far exceed current health care capacity, with a total of 81,114 deaths (95% uncertainty interval [UI], 38,242-162,106) over the next 4 months. 3 COVID-19 has led to unprecedented international public health measures, including mandatory social distancing, and prolonged school closures.…”

Cardiovascular system and COVID-19: perspectives from a developing country

“…As of April 8, 2020, a total of 1,760,978 laboratoryconfirmed cases has been documented worldwide with nearly 107,775 fatalities with United States, Spain and Italy being the most affected countries [4]. This rapid spread has been largely attributed to its high infectivity, prolonged asymptomatic phase and uninterrupted global travel [5]. Subsequently, after identification and isolation of this novel virus, the disease was christened as COVID-19 caused by the SARS-CoV-2 [6].…”