Utilizing multiple muscle flaps is a safe and reliable technique to provide stable soft tissue cover for major post-traumatic defects of the lower limbs. A fifty-five-year-old female patient presented to the emergency department with a huge crush/degloving injury of the whole anteromedial aspect of the right lower limb with open comminuted fracture of the femur, the tibia, and the fibula. Radiological computerized tomography (CT) study showed displaced comminuted fractures involving the lower shaft of the femur, proximal fibula, and middle third of the shaft of the tibia, with tangential bone loss in the knee joint. The patient underwent multiple sessions of wound and bone debridement with bone fixation which was followed by multiple reconstructive surgeries. Patient recovered well and was discharged home with the ability to mobilize with Zimmer frame and knee brace support. Keywords: Comminuted fractures, Degloving injuries, Muscles, Reconstructive surgical Procedures, Surgical flap