2013
DOI: 10.1016/j.peptides.2013.08.006
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The satiety signal oleoylethanolamide stimulates oxytocin neurosecretion from rat hypothalamic neurons

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Cited by 38 publications
(31 citation statements)
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“…These results are in line with the notion that the release of OXY from hypothalamic PVN neurons is involved in the negative regulation of food intake and body weight and participates to the hypophagic effects of several endogenous and exogenous compounds, such as leptin, CCK, and oleoylethanolamide [27,28,[49][50][51]. Moreover, the OXY system is also stressresponsive; in fact, an increase of OXY concentrations at both plasma and PVN level has been observed after different kinds of stress, such as immobilization, footshock, and shaking [41,[52][53][54].…”
Section: Discussionsupporting
confidence: 89%
“…These results are in line with the notion that the release of OXY from hypothalamic PVN neurons is involved in the negative regulation of food intake and body weight and participates to the hypophagic effects of several endogenous and exogenous compounds, such as leptin, CCK, and oleoylethanolamide [27,28,[49][50][51]. Moreover, the OXY system is also stressresponsive; in fact, an increase of OXY concentrations at both plasma and PVN level has been observed after different kinds of stress, such as immobilization, footshock, and shaking [41,[52][53][54].…”
Section: Discussionsupporting
confidence: 89%
“…OEA mediates fat-induced satiety by engaging sensory fibers of the vagus nerve that project centrally to the nucleus tractus solitarius (NTS). It was recently shown that noradrenergic NTSePVN projections are involved in the activation of the hypothalamic oxytocin system (Romano et al, 2013) and pharmacological blockade of oxytocin receptors in the brain prevents OEA anorexic effects (Gaetani et al, 2010). We observed that in histamine-deficient mice OEA-induced hypophagia was significantly attenuated, thus our hypothesis is that OEA induces anorexia indirectly stimulating histamine neurons.…”
Section: Interactions Between Central Histamine and Hormones In The Cmentioning
confidence: 53%
“…Oleoylethanolamide (OEA), an ethanolamide produced by the small intestine after feeding, reduces food consumption in both fed (15) and fasted (15,41) rats via central oxytocin (14). While OEA activates the NTS neurons, recent evidence suggests that the role of NTS in OEA-mediated satiety is via noradrenergic afferent input to PVN oxytocin neurons (42). Gaetani et al (14) reported that blocking oxytocin receptors in the third ventricle attenuated the anorexigenic effects of OEA without affecting NTS c-Fos activation, suggesting that oxytocin receptor activation in sites other than the NTS can also mediate feeding behavior.…”
Section: Discussionmentioning
confidence: 99%