The Saudi Initiative for Asthma - 2016 update: Guidelines for the diagnosis and management of asthma in adults and children

Al-Moamary, MohamedS; Alhaider, SamiA; Idrees, MajdyM; Ghobain, MohammedO Al; Zeitouni, MohammedO; Al-Harbi, AdelS; Yousef, Abdullah A; Al-Matar, Hussain; Alorainy, HassanS; Al-Hajjaj, MohamedS

doi:10.4103/1817-1737.173196

Cited by 60 publications

(79 citation statements)

References 429 publications

(667 reference statements)

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“…Its aerosol is characterized by rapid onset, good effect and fewer adverse reactions, and has been widely used in China (6,21). Budesonide is a kind of newly-synthesized non-halogenated adrenal cortical hormone, which has a high glucocorticoid receptor binding and strong anti-inflammatory effect, twice that of beclomethasone dipropionate.…”

Section: Discussionmentioning

confidence: 99%

Use of aerosol inhalation treatment with budesonide and terbutaline sulfate on acute pediatric asthmatic bronchitis

Bian

Zhang

2017

Experimental and Therapeutic Medicine

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The use of oxygen-driven aerosol inhalation therapy with budesonide (suspension) and terbutaline sulfate for the treatment of pediatric asthmatic bronchitis was studied. Sixty pediatric patients diagnosed with asthmatic bronchitis in Xuzhou Children's Hospital during the period comprising April 2013 to December 2015 were enrolled in the study. After randomly dividing the patients into a control (conventional dexamethasone drip) and a treatment group (inhalation of budesonide with terbutaline sulfate) of 30 patients each, the symptoms were treated using antibiotics when necessary. The results of our evaluation showed the overall effective rate of treatment in the control group was 73.33% (40% with marked improvement, 33.33% with some improvement and 26.67% with no improvement) and that in the treatment group was 96.67% (73.73% with marked improvement, 23.33% with some improvement and only 3.33% with no improvement) with a statistically significant difference (p<0.05). The pulmonary functions of all pediatric patients showed no statistically significant differences in the pulmonary function indexes between the two groups before treatment (p>0.05). However, the differences in FEV1, FVC, FEV1/FVC and PEF between control and treatment groups before and after treatment were statistically significant (p<0.05), with overall improvement being higher in the treatment group. Finally, the erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) level in patients of the two groups improved significantly after treatment (p<0.05). The ESR and CRP level in the treatment group were improved to a higher degree than those in the control group (p<0.05). There were only minor adverse reactions in two patients in the treatment group, and the overall rate of adverse reactions was not significantly different between the two groups (p>0.05). Based on our evaluation the aerosol inhalation therapy of budesonide (suspension) with terbutaline sulfate has definite curative effects and is safe to use on pediatric asthmatic bronchitis patients. The approach is superior to the conventional dexamethasone treatment and is worth studying in larger populations for recommending it widely.

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Section: Discussionmentioning

confidence: 99%

Use of aerosol inhalation treatment with budesonide and terbutaline sulfate on acute pediatric asthmatic bronchitis

Bian

Zhang

2017

Experimental and Therapeutic Medicine

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“…The grouping of children into obese and non-obese groups was based on their body mass index (BMI) percentile, because obesity is defined as a BMI greater than the 95th percentile for age and gender. In accordance with the guidelines of The Saudi Initiative for Asthma [20] and the Global Initiative for Asthma [21], asthma was diagnosed based on a history of recurrent or chronic chest symptoms such as coughing, wheezing, difficulty breathing, and chest tightness that demonstrated clinical reversibility with short-acting bronchodilator treatment. Symptom score in children with asthma was assessed according to a six-domain asthma symptom score that includes dyspnea, tightness in the chest, wheezing during the day, wheezing during the night, and daily performance [22].…”

Section: Study Design and Settingmentioning

confidence: 99%

Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children—Correlation with Interleukin-4, Interleukin-5, and Interleukin-21

Al-Ayed

Alshaibari

Alshehri

et al. 2020

IJERPH

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Ghrelin is a peptide hormone with direct or indirect effects on obesity and asthma. More data are required to understand the effect of ghrelin on the control and pathogenesis of these diseases. The aim of this study was to evaluate ghrelin levels in selected groups of children to identify the association between serum ghrelin, obesity, and the severity of asthma. The study included 401 school children selected from the Najran area and grouped into non-obese asthmatics, obese asthmatics, obese non-asthmatics and controls (non-obese non-asthmatics). Blood levels of ghrelin, interleukin (IL)-4, IL-5 and IL-21 were determined by ELISA. The mean ghrelin values were insignificantly increased in obese children compared with non-obese children. The highest blood ghrelin values were in the non-obese asthmatic group. Serum ghrelin, IL-4 and IL-21 levels were significantly increased in asthmatic children compared with non-asthmatic children (p < 0.05), and there were significant positive correlations between ghrelin and IL-4, IL-5, and IL-21 in asthmatic children. Furthermore, ghrelin, IL-4, and IL-21 levels were significantly higher in uncontrolled asthmatics compared with controlled-asthmatic children (p < 0.05). Asthma was the only significant risk factor for high ghrelin values. This study provides evidence supporting the anti-inflammatory role of ghrelin in the pathogenesis of asthma. Asthma might be considered as an important determinant of high ghrelin values in children.

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“…This can make breathing difficult and trigger coughing, wheezing and shortness of breath (1) . (4) .…”

Section: …………………………………………………………………………………………………… Introduction: -mentioning

confidence: 99%

Corticosteroid Phobia Among Parents of Asthmatic Children and Its Impact on Asthma Management in Hail Region.

Alshamary¹,

Alaezaimee²,

Aldokheel³

et al. 2018

IJAR

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The Saudi Initiative for Asthma - 2016 update: Guidelines for the diagnosis and management of asthma in adults and children

Cited by 60 publications

References 429 publications

Use of aerosol inhalation treatment with budesonide and terbutaline sulfate on acute pediatric asthmatic bronchitis

Use of aerosol inhalation treatment with budesonide and terbutaline sulfate on acute pediatric asthmatic bronchitis

Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children—Correlation with Interleukin-4, Interleukin-5, and Interleukin-21

Corticosteroid Phobia Among Parents of Asthmatic Children and Its Impact on Asthma Management in Hail Region.

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